Effect of Modified Huading Loulutang on Postoperative Recovery of Chronic Rhinosinusitis with Secretory Otitis Media Due to Toxic Heat Syndromes

Ling-min ZHANG; Jing-bo LI; Ji-tang CAI; Jun-jie WANG; Wen-ming CHEN

doi:10.13422/j.cnki.syfjx.20201726

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Effect of Modified Huading Loulutang on Postoperative Recovery of Chronic Rhinosinusitis with Secretory Otitis Media Due to Toxic Heat Syndromes

Clinic | 更新时间：2020-09-09

- Effect of Modified Huading Loulutang on Postoperative Recovery of Chronic Rhinosinusitis with Secretory Otitis Media Due to Toxic Heat Syndromes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 17, Pages: 77-82(2020)
- 作者机构：
  
  河南省中医院，郑州 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201726
  CLC： R22;R242;R2-031;R287
- Published Online：06 July 2020，
  
  Published：05 September 2020
- 稿件说明：
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张灵敏,李静波,蔡纪堂等.加味化疔漏芦汤治疗慢性鼻-鼻窦炎伴分泌性中耳炎毒热证患者术后的康复及机制[J].中国实验方剂学杂志,2020,26(17):77-82.

ZHANG Ling-min,LI Jing-bo,CAI Ji-tang,et al.Effect of Modified Huading Loulutang on Postoperative Recovery of Chronic Rhinosinusitis with Secretory Otitis Media Due to Toxic Heat Syndromes[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(17):77-82.
张灵敏,李静波,蔡纪堂等.加味化疔漏芦汤治疗慢性鼻-鼻窦炎伴分泌性中耳炎毒热证患者术后的康复及机制[J].中国实验方剂学杂志,2020,26(17):77-82. DOI： 10.13422/j.cnki.syfjx.20201726.

ZHANG Ling-min,LI Jing-bo,CAI Ji-tang,et al.Effect of Modified Huading Loulutang on Postoperative Recovery of Chronic Rhinosinusitis with Secretory Otitis Media Due to Toxic Heat Syndromes[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(17):77-82. DOI： 10.13422/j.cnki.syfjx.20201726.

摘要

目的

观察加味化疔漏芦汤对慢性鼻-鼻窦炎伴分泌性中耳炎毒热证患者术后康复效果

及血清、鼻分泌液、耳分泌液中嗜酸性粒细胞阳离子蛋白（ECP），免疫球蛋白E（IgE），细胞间黏附分子-1（ICAM-1）的影响。

方法

90例患者按照随机数字表法分为对照组和观察组，各45例。所有患者在鼻内窥镜术后给予头孢曲松钠+羟甲唑啉，对照组口服鼻渊通窍颗粒，观察组给予加味化疔漏芦汤，疗程均为6周。分别于治疗前后，随访6，18周观察两组患者鼻内镜检查量化评估量表（Lund-Kennedy），中医证状和不同频率听力阈值。治疗前后分别检测血清、鼻分泌液、耳分泌液中ECP，IgE，ICAM-1的含量。比较两组患者临床症状、并发症和随访12个月复发情况。

结果

观察组患者总控制率97.7%（43/44，95%CI [95.6，98.6]），高于对照组的78.6%（33/42，95%CI [72.4，83.5]

）（

=6.946，

0.05）。随访12个月，观察组患者复发率4.5%（2/44，95%CI[3.7，5.8]），低于对照组的19.0%（8/42，95%CI [16.8，21.3]

）（

=4.531，

0.05）。治疗后，随访6，18周观察组患者Lund-Kennedy和中医证状评分较对照组明显降低（

0.05）。治疗后观察组患者不同频率听力阈值较对照组明显降低（

0.05）。治疗后观察组患者血清、鼻分泌液、耳分泌液中ECP，IgE，ICAM-1含量较对照组明显降低（

0.05）。观察组患者并发症发生率6.8%（3/44，95%CI [5.3，8.1]），低于对照组的28.6%（12/42，95%CI [25.3，30.2]

）（

0.05）。

结论

加味化疔漏芦汤可明显改善慢性鼻-鼻窦炎伴分泌性中耳炎毒热证患者术后临床症状，复发率低。

Abstract

Objective

To observe the efficacy of modified Huading Loulutang on postoperative recovery of chronic rhinosinusitis with secretory otitis media due to toxic heat syndromes and the effect of eosinophil cationic protein (ECP)

immunoglobulin E (IgE) and intercellular adhesion molecule-1 (ICAM-1) in serum

nasal secretion and otitis media.

Method

According to the random number table method

90 cases were divided into control group and observation group

with 45 cases in each group. All patients were given ceftriaxone sodium + hydroxymezoline after nasal endoscopy. In addition

control group was given Biyuan Tongqiao granule

while observation group was given modified Huading Loulutang for 6 weeks. Lund-Kennedy nasal assessment scale

traditional Chinese medicine symptoms and threshold of hearing at different frequencies were observed in two groups before and after treatment and during 6-week and 18-week follow-up visits. The levels of ECP

IgE and ICAM-1 in serum

nasal and ear secretions were detected before and after treatment. Clinical symptoms

adverse reactions and 12-month recurrence rate were compared.

Result

Total control rate was 97.7%

(43/44

95%CI [95.6，98.6]) in observation group

which was higher than 78.6% (33/42

95%CI [72.4，83.5]

) in control group (

=6.946

0.05). During the 12-month follow-up visit

the recurrence rate was 4.5% (2/44

95%CI [3.7，5.8]) in observation group

which was lower than 19.0% (8/42

95%CI[16.8，21.3]

) in control group (

0.05). After treatment

Lund-Kennedy and traditional Chinese medicine symptoms score during 6-week and 18-week follow-up visits in observation group were significantly lower than those in control group (

0.05). Hearing threshold in observation group at different frequencies was significantly lower than that in control group (

0.05). ECP

IgE and ICAM-1 levels in serum

nasal and auricular secretions in observation group were significantly lower than those in control group (

0.05). The incidence of adverse reactions was 6.8% (3/44

95%CI [5.3，8.1]) in observation group

which was lower than 28.6% (12/42

95%CI [25.3，30.2]

) in control group (

0.05).

Conclusion

Modified Huading Loulutang can significantly improve postoperative clinical symptoms of chronic rhinosinusitis and otitis media due to toxic heat syndromes with secretion

with a low recurrence rate and fewer complications.

关键词

Keywords

references

FROST H M , GERBER J S , HERSH A L . Antibiotic recommendations for acute otitis media and acute bacterial sinusitis [J]. Pediatr Infect Dis J , 2019 , 382 : 217 - 223 .

胡守亮 , 李辉 , 朱天民 , 等 . 慢性鼻-鼻窦炎的病因及发病机制研究进展 [J]. 实用医学杂志 , 2019 , 35 ( 11 ): 1846 - 1849 .

李璐 , 李辉 , 朱天民 , 等 . 慢性鼻—鼻窦炎的治疗方法概述 [J]. 中华中医药学刊 , 2019 , 37 ( 12 ): 2860 - 2862 .

张涛 , 唐海红 , 郑宏良 . 大环内酯类抗菌药物治疗慢性鼻-鼻窦炎的机制及应用 [J]. 第二军医大学学报 , 2018 , 39 ( 12 ): 1364 - 1369 .

郭磊 , 黄维平 . 鼻炎康汤治疗胆腑郁热证慢性鼻-鼻窦炎60例临床分析 [J]. 中国实验方剂学杂志 , 2015 , 21 ( 9 ): 188 - 191 .

SEUNG N H , SEUNG H L , JEONG W K . Reply to the letter to the editor concerning: chronic rhinosinusitis with nasal polyps are associated with chronic otitis media in the elderly [J]. Eur Arch Otorhinolaryngol , 2017 , 274 ( 12 ): 4267 - 4268 .

ROUCE R H . The earlier the better: timely mitigation of CRS [J]. Blood , 2019 , 134 ( 24 ): 2119 - 2120 .

王翔 , 谭业农 , 谢柳 , 等 . 不同药物辅助治疗对老年慢性鼻-鼻窦炎伴鼻息肉患者术后血清 β -防御素水平和远期主客观量化指标的影响 [J]. 中国老年学杂志 , 2019 , 39 ( 16 ): 4019 - 4022 .

李静波 , 王俊杰 , 王慧敏 , 等 . 慢性鼻-鼻窦炎伴鼻息肉围手术期中医药替代激素治疗的疗效观察 [J]. 中药材 , 2019 , 42 ( 3 ): 676 - 679 .

杨大章 . 难治性慢性鼻-鼻窦炎的内镜手术和局部治疗进展 [J]. 临床耳鼻咽喉头颈外科杂志 , 2018 , 32 ( 21 ): 1614 - 1617 .

中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组 , 中华医学会耳鼻咽喉头颈外科学分会鼻科学组 . 慢性鼻-鼻窦炎诊断和治疗指南(2012年,昆明) [J]. 中华耳鼻咽喉头颈外科杂志 , 2013 , 48 ( 2 ): 92 - 94 .

郑中立 . 耳鼻咽喉科诊断学 [M]. 北京 : 人民卫生出版社 , 2006 : 243 - 249 .

国家中医药管理局 . 中华人民共和国中医药行业标准·中医病证诊断疗效标准 [M]. 南京 : 南京大学出版社 , 2010 : 431 - 437 .

王世贞 . 中医耳鼻喉科学 [M]. 北京 : 中国医药出版社 , 2003 : 126 - 132 .

LUND V J , KENNEDY D W . Staging for rhinosinusitis [J]. Otolaryngol Head Neck Surg , 1997 , 117 ( 3 ): 35 - 40 .

MOGI G , TOMONAGA K , WATANABE T , et al . The role of type I allergy in secret ory otitis media and mast cells in the middle ear mucosa [J]. Actaotol Otolaryngol Suppl , 1992 , 493 : 155 - 163 .

WELCH K . Because the medical management of chronicrhinosinusitis (CRS) is evolving rapidly and because we often become inundated with compelling and ground-breaking research, we occasionally focus more on the treatment and the science of CRS rather than symptoms and the diagnosis,introduction [J]. Int Forum Allergy Rhinol , 2013 , 3 ( 11 ): 859 - 860 .

LOU Z C . Assessment of laryngopharyngeal reflux and the shape of the eustachian tube should be considered in chronic rhinosinusitis with nasal polyps and chronic otitis media [J]. Eur Arch Otorhinolaryngol , 2017 , 274 ( 12 ): 4265 - 4266 .

徐娟 . 鼻内窥镜手术治疗慢性鼻窦炎伴中耳炎患者的疗效观察 [J]. 临床合理用药杂志 , 2019 , 12 ( 20 ): 150 - 151 .

秦惠珍 , 邹蓉 , 唐健民 , 等 . 12种清热解毒类药食两用植物研究进展 [J]. 广西科学院学报 , 2019 , 35 ( 1 ): 20 - 25 .

章锦秀 , 史剑波 . 慢性鼻窦炎鼻分泌物中嗜酸粒细胞阳离子蛋白的表达及临床意义 [J]. 暨南大学学报：自然科学与医学版 , 2011 , 32 ( 2 ): 215 - 217 .

余文婷 , 王颖 , 周玥 , 等 . 中性粒细胞中嗜酸粒细胞阳离子蛋白的表达及其对鼻部炎症客观评价的影响 [J]. 临床耳鼻咽喉头颈外科杂志 , 2019 , 33 ( 7 ): 581 - 585 .

刘翔 , 陈秋坚 , 杨金姗 , 等 . 血清特异性IgE检测在慢性鼻-鼻窦炎中的作用 [J]. 中国卫生检验杂志 , 2013 , 23 ( 10 ): 2288 - 2289，2300 .

池海超 , 陈觅 , 张杰 . 嗜酸乳酸杆菌对过敏性鼻炎模型大鼠血清中组胺、IL-5、IL-12及组织中ICAM-1的影响 [J]. 重庆医学 , 2015 , 44 ( 31 ): 4379 - 4381，4385 .

曾祥悦 , 孙海燕 , 李阳阳 , 等 . 广藿香酮对分泌性中耳炎模型豚鼠耳黏膜中TNF- α 及ICAM-1的表达影响研究 [J]. 中华中医药学刊 , 2019 , 37 ( 7 ): 1629 - 1633 .

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