Effect of Arisaema Rhizoma<italic style="font-style: italic"> </italic>and Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats

Su-rong HE; Jing WANG; Bo WU; Chun-yan QI; Jian-hua WU; Chang-li WANG; Chong-bo ZHAO; Chun-jie WU

doi:10.13422/j.cnki.syfjx.20201823

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Effect of Arisaema Rhizoma and Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats

Pharmacology | 更新时间：2020-09-09

- Effect of Arisaema Rhizoma and Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 18, Pages: 64-69(2020)
- 作者机构：
  
  1.陕西中医药大学，陕西省中药饮片工程技术研究中心，陕西咸阳 712046
  2.成都中医药大学，成都 611137
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201823
  CLC： R22;R242;R2-031;R285.5
- Received：05 April 2020，
  
  Published Online：16 July 2020，
  
  Published：20 September 2020
- 稿件说明：
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贺素容,王晶,吴博等.天南星和虎掌南星对大鼠水液代谢和血液流变学的影响[J].中国实验方剂学杂志,2020,26(18):64-69.

HE Su-rong,WANG Jing,WU Bo,et al.Effect of Arisaema Rhizomaand Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(18):64-69.
贺素容,王晶,吴博等.天南星和虎掌南星对大鼠水液代谢和血液流变学的影响[J].中国实验方剂学杂志,2020,26(18):64-69. DOI： 10.13422/j.cnki.syfjx.20201823.

HE Su-rong,WANG Jing,WU Bo,et al.Effect of Arisaema Rhizomaand Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(18):64-69. DOI： 10.13422/j.cnki.syfjx.20201823.

摘要

目的

观察天南星与虎掌南星对大鼠水液代谢和血液流变学的影响，探讨其作用机制。

方法

将50只健康SD大鼠随机分为5组，每组10只，分别是正常组，天南星高，低剂量组（1.2，0.3 g·kg·d

-1

），虎掌南星高，低剂量组（1.2，0.3 g·kg·d

-1

）。以排尿指数、排便量、大便含水量、颌下腺病理组织形态、肾脏中水通道蛋白2（aquaporin 2，AQP2）含量、血清中环磷腺苷/环磷酸鸟苷（adenosine cyclic 3′，5′-hydrogen phosphate/current good manufacture practices

cAMP/cGMP）和三磷酸腺苷酶（ATPase

-K

-ATP酶）含量为水液代谢评价指标，以全血黏度（whole blood viscosity，WBV）和红细胞聚集指数（erythrocyte aggregation index，RE）为血液流变学评价指标，分别来比较天南星与虎掌南星对大鼠水液代谢和血液流变学作用大小。

结果

与正常组比较，高剂量组天南星和虎掌南星均使大鼠排便量、大便含水量和AQP2表达明显性降低（

0.05），颌下腺组织中腺泡萎缩，排尿指数，cAMP/cGMP和Na

-K

-ATP酶含量明显升高（

0.05），WBV和RE明显升高（

0.05）；但两组间差异无统计学意义。

结论

高剂量的天南星和虎掌南星对大鼠水液代谢和血液流变学均有明显影响，表明临床用药时应注意天南星和虎掌安全性，为2种药物临床上的合理用药提供了理论依据。

Abstract

Objective

To discuss the effect of Arisaema Rhizoma and Pinelliae Pedatisectae Rhizoma on water metabolism and hemorheolog in rats.

Method

A total of 50 healthy SD rats were randomly divided into 5 groups

namely normal group

high-dose Arisaema Rhizoma group (1.2 g·kg·d

-1

)

low-dose Arisaema Rhizoma group (1.2 g·kg·d

-1

)

high-dose Pinelliae Pedatisectae Rhizoma group (1.2 g·kg·d

-1

) and low dose Pinelliae Pedatisectae Rhizoma group (0.3 g·kg·d

-1

)

with 10 rats in each group

The effects of Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma on water metabolism and hemorheology were compared

with the micturition index

fecal volume

fecal water content

pathological morphology of submandibular gland

aquaporin (AQP2) content in kidney

adenosine cyclic 3′

5′-(hydrogen phosphate)/current good manufacture practices (cAMP/cGMP) and Na

-K

-ATP enzyme content in serum as the evaluation indexes of water metabolism

and the whole blood viscosity (WBV) and erythrocyte aggregation index (RE) as the evaluation indexes of hemorheolog.

Result

Compared with normal group

the fecal volume

fecal water content and AQP2 expression decreased significantly， acinus of submandibular gland were atrophied， micturition index

cAMP/cGMP and Na

-K

-ATP enzyme content in serum were increased significantly， WBV and RE were increased significantly in high-dose

Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma groups（

0.05）

but with no significant difference between them.

Conclusion

High-dose Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma groups had significant effects on water metabolism and hemorheology in rats

suggesting that attention shall be given to the safety of Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma. And this study provides a theoretical basis for the rational use of the two traditional Chinese medicines in clinic.

关键词

Keywords

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Effect of Arisaema Rhizoma and Pinelliae Pedatisectae Rhizoma on Water Metabolism and Hemorheology in Rats

DOI：10.13422/j.cnki.syfjx.20201823

摘要

Abstract

关键词

Keywords

references