Effect of M1/M2 Alveolar Macrophage Subsets in COVID-19 and Regulatory Mechanism of Traditional Chinese Medicine

Jun-jie LI; Ya-ling LI; Yong-qi LIU; Zhi-ming ZHANG; Juan-juan DONG; Gao-qin LI; Dong-ling LIU; Xiao-jie JIN; Li-ying ZHANG

doi:10.13422/j.cnki.syfjx.20201907

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Effect of M1/M2 Alveolar Macrophage Subsets in COVID-19 and Regulatory Mechanism of Traditional Chinese Medicine

Topic on Epidemic Resistance | 更新时间：2020-09-16

- Effect of M1/M2 Alveolar Macrophage Subsets in COVID-19 and Regulatory Mechanism of Traditional Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 19, Pages: 99-107(2020)
- 作者机构：
  
  1.甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室，兰州 730000
  2.甘肃中医药大学基础医学院，兰州 730000
  3.甘肃中医药大学附属医院，兰州 730000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201907
  CLC： R2-0;R22;R285.5;R284
- Received：26 May 2020，
  
  Published Online：21 July 2020，
  
  Published：05 October 2020
- 稿件说明：
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李俊杰,李亚玲,刘永琦等.M1/M2型肺泡巨噬细胞亚群在新型冠状病毒肺炎中的作用及中医药调控机制研究进展[J].中国实验方剂学杂志,2020,26(19):99-107.

LI Jun-jie,LI Ya-ling,LIU Yong-qi,et al.Effect of M1/M2 Alveolar Macrophage Subsets in COVID-19 and Regulatory Mechanism of Traditional Chinese Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(19):99-107.
李俊杰,李亚玲,刘永琦等.M1/M2型肺泡巨噬细胞亚群在新型冠状病毒肺炎中的作用及中医药调控机制研究进展[J].中国实验方剂学杂志,2020,26(19):99-107. DOI： 10.13422/j.cnki.syfjx.20201907.

LI Jun-jie,LI Ya-ling,LIU Yong-qi,et al.Effect of M1/M2 Alveolar Macrophage Subsets in COVID-19 and Regulatory Mechanism of Traditional Chinese Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(19):99-107. DOI： 10.13422/j.cnki.syfjx.20201907.

摘要

新型冠状病毒肺炎（COVID-19）死亡患者的病理解剖结果显示肺部过度的炎症反应是诱发急性肺损伤或急性呼吸窘迫综合征等并发症的重要原因之一，调节过度的免疫应答对治疗该病有重要的意义。肺泡巨噬细胞具有高度的异质性和可塑性，在机体感染早期和后期，M1/M2型肺泡巨噬细胞亚群平衡及功能的动态变化对肺部炎性反应具有显著的影响。本文综述巨噬细胞的分型及功能，探讨巨噬细胞在新冠肺炎不同阶段病理过程的作用机制以及中药治疗的药效机制，为中医药治疗新型冠状病毒肺炎以及基于调控巨噬细胞极化的药物研发上提供思路。

Abstract

The pathological anatomical results of coronavirus disease-2019 (COVID-19) patients showed that excessive inflammatory reaction in the lungs is one of the important causes for such complications as acute lung injury or acute respiratory distress syndrome. Therefore

regulation of immune response may be an effective measure for COVID-19. Alveolar macrophages have a high heterogeneity and plasticity. The dynamic changes of subsets balance and function of M1/M2 alveolar macrophages have a significant effect on pulmonary inflammatory response during the early and late stages of infection. This paper reviews the classification and function of macrophages and explores the mechanism of alveolar macrophage in the pathological process of COVID-19 at different stages and the pharmacodynamic mechanism of traditional Chinese medicine. Besides

it provides ideas for the treatment of COVID-19 with traditional Chinese medicine and other drugs' research and development based on the regulation of macrophage polarization.

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references

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