Clinical Observation on Shiwei Wendantang in Treating Post-ischemic Stroke Depression of Heart and Gallbladder Qi Deficiency Syndrome

Juan LIU; Cheng ZHONG; Jing-tao PANG; Li TIAN

doi:10.13422/j.cnki.syfjx.20201921

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Clinical Observation on Shiwei Wendantang in Treating Post-ischemic Stroke Depression of Heart and Gallbladder Qi Deficiency Syndrome

Clinic | 更新时间：2020-09-16

- Clinical Observation on Shiwei Wendantang in Treating Post-ischemic Stroke Depression of Heart and Gallbladder Qi Deficiency Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 19, Pages: 189-194(2020)
- 作者机构：
  
  1.潍坊市中医院，山东潍坊 261041
  2.潍坊护理职业学院，山东潍坊 252300
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201921
  CLC： R22;R242;R2-031;R287
- Received：20 October 2019，
  
  Published Online：23 July 2020，
  
  Published：05 October 2020
- 稿件说明：
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刘娟,仲诚,庞敬涛等.十味温胆汤治疗缺血性卒中后抑郁心胆气虚证的临床观察[J].中国实验方剂学杂志,2020,26(19):189-194.

LIU Juan,ZHONG Cheng,PANG Jing-tao,et al.Clinical Observation on Shiwei Wendantang in Treating Post-ischemic Stroke Depression of Heart and Gallbladder Qi Deficiency Syndrome[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(19):189-194.
刘娟,仲诚,庞敬涛等.十味温胆汤治疗缺血性卒中后抑郁心胆气虚证的临床观察[J].中国实验方剂学杂志,2020,26(19):189-194. DOI： 10.13422/j.cnki.syfjx.20201921.

LIU Juan,ZHONG Cheng,PANG Jing-tao,et al.Clinical Observation on Shiwei Wendantang in Treating Post-ischemic Stroke Depression of Heart and Gallbladder Qi Deficiency Syndrome[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(19):189-194. DOI： 10.13422/j.cnki.syfjx.20201921.

摘要

目的

观察十味温胆汤治疗缺血性卒中后抑郁心胆气虚证临床疗效，探究其作用机制。

方法

将缺血性卒中后抑郁心胆气虚证患者80例，采用随机数字表法分组。对照组40例，给予口服用抗抑郁药帕罗西汀20 mg·d

-1

；观察组40例，十味温胆汤内服，1剂/d。两组疗程均为连续治疗4周。观察两组的临床疗效、汉密尔顿抑郁量表-17（HAMD-17）因子评分，血清C-反应蛋白（CRP），同型半胱氨酸（Hcy）水平，中医证候积分、生活质量评分，并进行比较。

结果

经过治疗，观察组疗效明显优于对照组（

=-2.104，

0.05），且总有效率明显高于对照组（

=5.00，

0.05）；与本组治疗前进行比较，观察组患者的HAMD量表-17各因子评分均明显减少（

0.05），对照组患者的HAMD量表-17各因子评分除绝望感、焦虑两项无差异，其他各项因子评分均明显减少（

0.05）；与对照组治疗后比较，观察组HAMD量表-17各因子评分减少更明显（

0.05）。与本组治疗前比较，治疗后两组患者血清CRP，Hcy水平均显著降低（

0.01）；与对照组治疗后比较，观察组血清CRP，Hcy水平降低更明显（

0.05）。与本组治疗前比较，治疗后观察组患者中医证候评分均显著减少（

0.01），对照组患者小便清长明显降低（

0.05）。与本组治疗前比较，治疗后观察组患者生活质量评分均显著提高（

0.01），对照组患者SF-36健康调查简表评分除精力、社会职能，其他评分均明显提高（

0.05），观察组治疗后躯体功能、生理智能、躯体疼痛、社会职能、精神健康评分较对照组明显升高（

0.05）。

结论

与常规西医治疗比较，十味温胆汤治疗缺血性卒中后抑郁心胆气虚证，可进一步减轻患者的抑郁程度，改善抑郁症状，提高生活质量，临床疗效和综合效果更为明显。

Abstract

Objective

To observe the clinical efficacy of Shiwei Wendantang on post-ischemic stroke depression of heart and gallbladder Qi deficiency syndrome.

Method

The 80 patients with post-ischemic stroke depression of heart and gallbladder Qi deficiency syndrome were divided into two groups by random number table. 40 cases in control group received oral administration of antidepressant Paroxetine

20 mg·d

-1

and 40 cases in observation group received Shiwei Wendantang

1 dose/day. The treatment course was 4 weeks in both groups. The clinical efficacy

hamilton depression scale (HAMD-17) score

serum C-reactive protein (CRP)

homocysteine (Hcy) level

traditional Chinese medicine(TCM) syndrome score and quality of life score of two groups were observed and compared.

Result

After treatment

the curative effect of observation group was better than that of the control group (

=-2.104，

0.05)

and the total effective rate in observation group was significantly higher than that of control group（

=5.00，

0.05）. After treatment

the scores of each factor of HAMD-17 scale in observation group were significantly decreased (

0.05)

and the scores of factors of HAMD-17 scale in the control group were also significantly decreased (

0.05) except despair and anxiety. The decrease of scores in the observation group was more obvious than that in the control group (

0.05). After treatment

the values of serum CRP and Hcy in two groups were decreased significantly (

0.01）

and the values of serum CRP and Hcy in observation group were also decreased significantly (

0.01）.After treatment

the scores of TCM syndromes in observation group were decreased significantly (

0.01）， while in control group

only the score of urination was significantly decreased（

0.05）. The scores of quality of life in observation group were all significantly higher than those before treatment (

0.01）. The scores of SF-36 Health Survey Form in the control group were significantly decreased except for energy and social function (

0.05). The scores of physical function

physical intelligence

physical pain

social function

and mental health in observation group were significantly higher than those in the control group (

0.05).

Conclusion

As compared with the conventional western medicine treatment

the application of Shiwei Wendantang in the treatment of post-ischemic stroke depression of heart and gallbladder Qi deficiency syndrome

can further reduce the degree of depression of patients

improve the symptoms of depression

and improve the quality of life

with more significant clinical efficacy and comprehensive effect.

关键词

Keywords

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