Effect of Qihong Capsule on Heart Hemodynamics and Myocardial Consumption of Oxygen in Heart Failure Model Beagle

Hao GUO; Jian-xun REN; Lei LI; Jian-xun LIU; Xiao-feng WANG; Jun-guo REN; Xiao HAN; Long JIN; Yue SHI; Yan-lei MA

doi:10.13422/j.cnki.syfjx.20202043

您当前的位置：

首页 >

文章列表页 >

Effect of Qihong Capsule on Heart Hemodynamics and Myocardial Consumption of Oxygen in Heart Failure Model Beagle

Pharmacology | 更新时间：2020-09-16

- Effect of Qihong Capsule on Heart Hemodynamics and Myocardial Consumption of Oxygen in Heart Failure Model Beagle
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 20, Pages: 67-73(2020)
- 作者机构：
  
  1.中国中医科学院西苑医院基础医学研究所中药药理北京市重点实验室，北京 100091
  2.新疆医科大学附属中医医院，乌鲁木齐 830000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20202043
  CLC： R2-0;R289;R514.6+1
- Received：22 October 2019，
  
  Published Online：14 August 2020，
  
  Published：20 October 2020
- 稿件说明：
移动端阅览
郭浩,任建勋,李磊等.芪红胶囊对心衰模型比格犬血流动力学及血氧含量的影响[J].中国实验方剂学杂志,2020,26(20):67-73.

GUO Hao,REN Jian-xun,LI Lei,et al.Effect of Qihong Capsule on Heart Hemodynamics and Myocardial Consumption of Oxygen in Heart Failure Model Beagle[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):67-73.
郭浩,任建勋,李磊等.芪红胶囊对心衰模型比格犬血流动力学及血氧含量的影响[J].中国实验方剂学杂志,2020,26(20):67-73. DOI： 10.13422/j.cnki.syfjx.20202043.

GUO Hao,REN Jian-xun,LI Lei,et al.Effect of Qihong Capsule on Heart Hemodynamics and Myocardial Consumption of Oxygen in Heart Failure Model Beagle[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):67-73. DOI： 10.13422/j.cnki.syfjx.20202043.

摘要

目的

从血流动力学及血氧含量等相关指标的角度探讨芪红胶囊对戊巴比妥钠诱导心衰模型比格犬的治疗作用。

方法

采用健康成年比格犬30只，随机分为6组，每组6只，分别为正常组，模型组，地高辛片组(40 μg·kg

-1

)，芪红胶囊高、中、低剂量组(2.6，1.3，0.65 g·kg

-1

)，采用静脉泵注2%戊巴比妥钠的方法建立比格犬心衰模型，以左室内压上升最大速率降低70%作为模型成功的标准，后经十二指肠给予相应药物，用多道生理记录仪分别测量肢体标准Ⅱ导联心电图、冠状动脉血流量、心输出量、左室内压、左室内压上升最大速率。罗氏血氧分析仪测定不同时间点动脉血氧含量、冠状静脉窦血氧含量，并计算心肌氧利用率。

结果

比格犬在静脉泵注2%戊巴比妥钠15 min左右，开始出现明显心衰症状，主要表现Ⅱ导心电图PR间期增加，冠脉血流量、左室内压、心输出量、心搏出量、静脉血氧含量显著降低、而心肌氧利用率显著增高，与正常组比较有显著差异（

0.01），为与模型组比较，1.3 g·kg

-1

芪红胶囊在给药后60~120 min显著增加冠脉血流量（

0.05），其最大增幅为36%，2.6 g·kg

-1

芪红胶囊在给药后45~60 min心搏出量增加明显，最大增幅约16%，与模型组比较有显著差异（

0.05）。同时能够增加冠静脉窦血氧含量，提示心肌供氧量升高，氧用率降低，芪红胶囊1.3 g·kg

-1

组给药60 min后能显著增加左室内压上升最大速率（

0.05），最大增幅约42%。

结论

芪红胶囊能够同时增加冠脉血流量及静脉血氧含量，使得心肌养供应充分，氧的利用率降低，在此基础上，芪红胶囊才能进一步增加心输出量和改善心脏功能，从而发挥心衰保护的作用。

Abstract

Objective

To investigate the therapeutic effect of Qihong capsule on pentobarbital sodium induced heart failure in beagle dogs.

Method

Thirty healthy adult beagle dogs were randomly divided into 6 groups

6 in each group. They were normal group

model group

digoxin tablet group (40 μg·kg

-1

)

Qihong capsule high

medium and low dose groups (2.6，1.3，0.65 g·kg

-1

). The heart failure model of beagle dogs was established by intravenous infusion of 2% pentobarbital sodium. The success standard of the model was that the maximum rate of rise of left ventricular pressure was reduced by 70%.The corresponding drugs were given through duodenum. The Ⅱ lead electrocardiogram

coronary blood flow

cardiac output

left ventricular pressure and maximum rate of left ventricular pressure rise were measured by multi-channel physiological recorder. The arterial oxygen content and coronary sinus oxygen content were measured by Roche blood oxygen analyzer at different time points

and the myocardial oxygen utilization rate was calculated.

Result

After intravenous infusion of 2% pentobarbital sodium for about 15 minutes

beagle dogs began to show obvious symptoms of heart failure. The main manifestations were the increase of PR interval of Ⅱ lead electrocardiogram

the decrease of coronary blood flow

left ventricular pressure

cardiac output

venous oxygen content

and the increase of myocardial oxygen utilization rate (

0.01) compared with the model group

Qihong capsule significantly increased coronary blood flow at 60-120 min after treatment (

0.05). The cardiac output of 2.6 g·kg

-1

Qihong capsule increased significantly at 45-60 min after treatment

with the maximum increase of about 16%

which was significantly different from that of model group (

0.05). At the same time

it can increase the oxygen content of coronary sinus blood

which indicates that the myocardial oxygen supply is increased and the oxygen utilization rate is decreased. Qihong capsule 1.3 g·kg

-1

group significantly increased the maximum rate of left ventricular pressure rise (

0.05)

the maximum increase rate was about 42%.

Conclusion

Qihong capsule can increase coronary blood flow and venous blood oxygen content at the same time

make myocardial nutrient supply sufficient

reduce oxygen utilization rate

on this basis

Qihong capsule can further increase cardiac output and improve cardiac function

so as to play a protective role in heart failure.

关键词

Keywords

references

ABI-SAMRA F ， GUTTERMAN D . Cardiac contractility modulation：a novel approach for the treatment of heart failure [J]. Heart Fail Rev ， 2016 ， 21 （ 6 ）： 645 - 660 .

王荣辉，曾广权，谢统辉，等 . 美托洛尔治疗慢性心力衰竭的5年远期随访资料分析 [J]. 中国实用医药， 2018 ， 13 （ 15 ）： 8 - 10 .

王臻，李洁白，董昕，等 . 补阳还五汤对舒张性心衰大鼠心肌线粒体能量代谢及AMPK/PPAR α 信号通路的影响 [J]. 中国实验方剂学杂志， 2019 ， 25 （ 9 ）： 12 - 17 .

张国顺，白义萍，王小兰，等 . 葶苈子抗心衰有效组分筛选及其作用机制分析 [J]. 中国实验方剂学杂志， 2017 ， 23 （ 4 ）： 118 - 125 .

王倩，姚耿圳，潘光明，等 . 基于数据挖掘的慢性心力衰竭气虚血瘀证用药规律分析 [J]. 中国中药杂志， 2017 ， 42 （ 1 ）： 182 - 186 .

刘兆龙，聂继红，张艳君 . 芪红胶囊水提工艺研究 [J]. 中国民族民间医药， 2011 ， 20 （ 20 ）： 28 - 29，32 .

刘兆龙，聂继红，夏昌隆 . 芪红胶囊醇提工艺的研究 [J]. 新疆医科大学学报， 2009 ， 32 （ 12 ）： 1696 - 1697 .

宋晓东，嵇波，刘玉清 . 芪红胶囊对柯萨奇病毒引起细胞凋亡的影响 [J]. 中国中西医结合杂志， 2005 ， 25 （ 6 ）： 511 - 515 .

王仑，宋晓东，嵇波，等 . 芪红胶囊对病毒性心肌炎小鼠的保护作用 [J]. 北京中医药大学学报， 2005 ， 28 ( 2 ): 56 - 59 .

宋晓东，辛颖，刘哲，等 . 芪红胶囊通过免疫调节治疗病毒性心肌炎小鼠 [J]. 中国实验动物学报， 2009 ， 17 （ 2 ）： 85 - 89 .

阿热依·贾尔肯 . 芪红胶囊治疗慢性心力衰竭气虚血瘀证的临床疗效观察 [D]. 乌鲁木齐：新疆医科大学， 2018 .

仝淼，范辉，高玉，等 . 心脉隆注射液联合芪红胶囊治疗难治性心力衰竭的临床研究 [J]. 中西医结合心脑血管病杂志， 2016 ， 14 （ 16 ）： 1825 - 1828 .

曹雪琴 . 芪红胶囊佐治酒精性心肌病的临床疗效评价 [J]. 中西医结合心血管病电子杂志， 2016 ， 4 （ 32 ）： 49 .

徐淑云，卞如濂，陈修 . 药理实验方法学 [M].3版.北京：人民卫生出版社， 2002 ： 1861 - 1863 .

卢志强，张艳军，庄朋伟，等 . 附子对急性心力衰竭大鼠血流动力学影响及其机制研究 [J]. 中草药， 2015 ， 46 （ 21 ）： 3223 - 3227 .

冉亚军，陈继红，王晓峰 . 芪红散治疗心衰经验 [J]. 中国实验方剂学杂志， 2012 ， 18 （ 24 ）： 340 - 342 .

李磊，刘建勋，任建勋，等 . 祛瘀化痰通脉颗粒对比格犬心脏血流动力学及心肌耗氧量的影响 [J]. 中国实验方剂学杂志， 2017 ， 23 （ 9 ）： 90 - 98 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on Hemodynamic Effect and Compatibility Proportion of Chinese Herbs with Reinforcing Qi, Warming Yang, Activating Blood and Promoting Diuresis in Treating Rabbits with Heart Failure

Study on Hemodynamic Effect and Compatibility Proportion of Chinese Herbs with Reinforcing Qi,Warming Yang,Activating Blood and Promoting Diuresis in Treating Rabbits with Heart Failure

Analysis of Potential Active Components and Molecular Mechanism of Baoxin Granules Regulating Ferroptosis in Treatment of Heart Failure

Effect of Qingxin Jieyu Granules Regulating Mitophagy on Ventricular Remodeling After Myocardial Infarction of C57B/L6 Mice

Material Basis and Its Distribution in vivo of Qili Qiangxin Capsules Analyzed by UPLC-Q-Orbitrap-MS

Related Author

SHEN Shu-jing

XIAN Shao-xiang

HUANG Yan-shou

HUANG Ping-dong

SHEN Shu-jing1

XIAN Shao-xiang2

HUANG Yan-shou2

HUANG Ping-dong3

Related Institution

Guangzhou University of Traditional Chinese Medicine

广州中医药大学第一附属医院

广州中医药大学第三附属医院芳村分院

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs， Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

Jiangxi Province Key Laboratory of Traditional Chinese Medicine（TCM） Pharmacology，Institute of TCM Health Industry，China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰