Meta-analysis of Distribution Frequency of Traditional Chinese Medicine Syndrome in Primary Osteoporosis

WU Hailong; CHANG Tianying; LU Yan; LUO Zongjian; LENG Xiangyang; LIAO Xing

doi:10.13422/j.cnki.syfjx.20231150

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Meta-analysis of Distribution Frequency of Traditional Chinese Medicine Syndrome in Primary Osteoporosis

更新时间：2024-02-28

- Meta-analysis of Distribution Frequency of Traditional Chinese Medicine Syndrome in Primary Osteoporosis
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 30, Issue 5, Pages: 111-117(2024)
- 作者机构：
  
  1.长春中医药大学，长春 130117
  2.长春中医药大学循证医学中心，长春 130117
  3.长春中医药大学附属医院，长春 130021
  4.中国中医科学院中医临床基础医学研究所，北京 100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20231150
  CLC： R22;R24;R273;O279
- Received：08 May 2023，
  
  Published Online：26 June 2023，
  
  Published：05 March 2024
- 稿件说明：
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吴海龙,常天瀛,卢焱等.原发性骨质疏松症中医证候分布频率的Meta分析[J].中国实验方剂学杂志,2024,30(05):111-117.

WU Hailong,CHANG Tianying,LU Yan,et al.Meta-analysis of Distribution Frequency of Traditional Chinese Medicine Syndrome in Primary Osteoporosis[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(05):111-117.
吴海龙,常天瀛,卢焱等.原发性骨质疏松症中医证候分布频率的Meta分析[J].中国实验方剂学杂志,2024,30(05):111-117. DOI： 10.13422/j.cnki.syfjx.20231150.

WU Hailong,CHANG Tianying,LU Yan,et al.Meta-analysis of Distribution Frequency of Traditional Chinese Medicine Syndrome in Primary Osteoporosis[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(05):111-117. DOI： 10.13422/j.cnki.syfjx.20231150.

摘要

目的

运用循证医学方法，系统评价我国原发性骨质疏松症（POP）中医证候分布情况，了解其证候分布规律。

方法

检索中国知识基础设施工程（CNKI）、维普中文科技期刊数据库（VIP）、万方数据知识服务平台（WanFang）及中国生物医学文献数据库（CBM），获得代表性文献，各个数据库检索时间均为1994年世界卫生组织定义骨质疏松症诊断标准至2023年5月1日。由2位研究者根据筛选标准独立筛选文献、提取资料并交叉核对，采用R 4.1.3软件进行Meta分析并进行亚组分析。

结果

共纳入56篇中文文献，涉及14 415例患者。证候标准化分类后排除11篇文献，最终纳入的45篇中文文献的Meta分析结果显示，12 723例患者肝肾阴虚证、脾肾阳虚证、肾虚血瘀证的证候分布频率分别为27%［95%置信区间（CI）0.24~0.31］、32%（95% CI 0.29~0.36）、36%（95% CI 0.30~0.42）。亚组分析结果显示，上述3种中医证候在南北方分布差异具有统计学意义（

0.05）。此外，不同类型POP中医证候骨折发生率分别为肝肾阴虚证15%（95% CI 0.09~0.24）、脾肾阳虚证20%（95% CI 0.12~0.30）、肾虚血瘀证31%（95% CI 0.25~0.39）。

结论

POP患者的证候分布以肾虚为主，兼见肝脾功能失调。肝肾阴虚证、脾肾阳虚证、肾虚血瘀证均是POP及骨质疏松性骨折发生的主要证候，且肾虚血瘀证与骨质疏松性骨折的发病关系最为密切。纳入研究间证候判定参考标准不一致，未来要重点围绕其判定标准，获得共识性研究结果；同时，开展大样本的证候调研，获得具有代表性的研究结果，为临床实践和研究提供依据。

Abstract

Objective

To systematically evaluate the distribution of traditional Chinese medicine（TCM） syndromes of primary osteoporosis（POP） in China by using evidence-based medicine methods， and to understand the distribution law of the syndromes.

Method

China National Knowledge Infrastructure（CNKI）， VIP Chinese Science and Technology Journal Database（VIP）， WanFang Data Knowledge Service Platform（WanFang） and China Biology Medicine（CBM） were searched to obtain representative literature， and each database was searched from the 1994 World Health Organization defined diagnostic criteria for osteoporosis until May 1， 2023. Two researchers independently screened literature according to the criteria， extracted data， and cross-checked them. Meta analysis was conducted using R4.1.3， and subgroup analysis was performed.

Result

A total of 56 Chinese papers were included， involving 14 415 patients. After standardized classification of syndromes， 11 articles were excluded， and Meta analysis results of the ultimately included 45 Chinese articles showed that the distribution frequencies of liver-kidney Yin deficiency syndrome， spleen-kidney Yang deficiency syndrome and kidney deficiency and blood stasis syndrome in 12 723 patients were 27%［95% confidence interval（CI） 0.24-0.31］， 32%（95% CI 0.29-0.36）， 36%（95% CI 0.30-0.42）. Subgroup analysis showed that there was a statistically significant difference in the distribution of the three TCM syndromes in the north and south（

0.05）. In addition， the incidence of TCM syndrome fractures in different types of POP was 15%（95% CI 0.09-0.24） for liver-kidney Yin deficiency syndrome， 20%（95% CI 0.12-0.30） for spleen-kidney Yang deficiency syndrome， and 31%（95% CI 0.25-0.39） for kidney deficiency and blood stasis syndrome.

Conclusion

The distribution of syndromes in POP patients is mainly kidney deficiency， accompanied by liver and spleen dysfunction. Liver-kidney Yin deficiency syndrome， spleen-kidney Yang deficiency syndrome and kidney deficiency and blood stasis syndrome are all the main syndromes of POP and osteoporotic fractures， and kidney deficiency and blood stasis syndrome is most closely related to the development of osteoporotic fractures. The reference standards for syndrome determination among the included studies are inconsistent， and in the future， it is necessary to focus on their determination standards to obtain consensus research results， at the same time， conduct large-scale syndrome research to obtain representative research results， providing a basis for clinical practice and research.

关键词

Keywords

references

MIRZA F ， CANALIS E . Management of endocrine disease：Secondary osteoporosis：Pathophysiology and management ［J］. Eur J Endocrinol ， 2015 ， 173 （ 3 ）： R131 - R151 .

SCHEIDT-NAVE C ， ZIEGLER R ， RASPE H . Epidemiology of osteoporosis ［J］. Med Klin（Munich）， 1998 ， 93 （ Suppl 2 ）： 7 - 11 .

LANE N E . Epidemiology，etiology，and diagnosis of osteoporosis ［J］. Am J Obstet Gynecol ， 2006 ， 194 （ Suppl 2 ）： S3 - S11 .

朱洁云，高敏，宋秋韵，等 . 中国老年人骨质疏松症患病率的Meta分析［J］. 中国全科医学， 2022 ， 25 （ 3 ）： 346 - 353 .

VOKÓ Z ， GÁSPÁR K ， INOTAI A ， et al . Osteoporotic fractures may impair life as much as the complications of diabetes ［J］. J Eval Clin Pract ， 2017 ， 23 （ 6 ）： 1375 - 1380 .

HAMDY R C . Osteoporosis，the deafening silent epidemic ［J］. South Med J ， 2002 ， 95 （ 6 ）： 567 - 568 .

夏维波，章振林，林华，等 . 原发性骨质疏松症诊疗指南（2017）［J］. 中国骨质疏松杂志， 2019 ， 25 （ 3 ）： 281 - 309 .

STROUP D F ， BERLIN J A ， MORTON S C ， et al . Meta-analysis of observational studies in epidemiology：A proposal for reporting.Meta-analysis of observational studies in epidemiology（MOOSE） group ［J］. JAMA ， 2000 ， 283 （ 15 ）： 2008 - 2012 .

SIRIS E S ， ADLER R ， BILEZIKIAN J ， et al . The clinical diagnosis of osteoporosis：A position statement from the National Bone Health Alliance Working Group ［J］. Osteoporos Int ， 2014 ， 25 （ 5 ）： 1439 - 1443 .

姚新苗，史晓林，王健，等 . 浙江省中医药防治原发性骨质疏松症分级诊疗专家共识（2017）［J］. 浙江中医杂志， 2018 ， 53 （ 4 ）： 237 - 241 .

中华中医药学会 . 绝经后骨质疏松症（骨痿）中医药诊疗指南（2019年版）［J］. 中医正骨， 2020 ， 32 （ 2 ）： 1 - 13 .

葛继荣，王和鸣，郑洪新，等 . 中医药防治原发性骨质疏松症专家共识（2020）［J］. 中国骨质疏松杂志， 2020 ， 26 （ 12 ）： 1717 - 1725 .

谢雁鸣，刘峘，姜俊杰，等 . 绝经后骨质疏松症中医临床实践指南（征求意见稿）［J］. 中国中药杂志， 2021 ， 46 （ 22 ）： 5992 - 5998 .

中国健康促进基金会基层医疗机构骨质疏松症诊断与治疗专家共识委员会 . 基层医疗机构骨质疏松症诊断和治疗专家共识（2021）［J］. 中国骨质疏松杂志， 2021 ， 27 （ 7 ）： 937 - 944 .

曾宪涛，刘慧，陈曦，等 . Meta分析系列之四：观察性研究的质量评价工具［J］. 中国循证心血管医学杂志， 2012 ， 4 （ 4 ）： 297 - 299 .

罗美玲，谭红专，周权，等 . 在R软件中实现单个率的Meta分析［J］. 循证医学， 2013 ， 13 （ 3 ）： 181 - 184，188 .

冷向阳，马勇 . 中医正骨学［M］. 北京：中国中医药出版社， 2021 .

赵文海，詹红生 . 中医骨伤科学［M］. 上海：上海科学技术出版社， 2020 .

CUMMINGS S R ， KARPF D B ， HARRIS F ， et al . Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs ［J］. Am J Med ， 2002 ， 112 （ 4 ）： 281 - 289 .

LASKEY M A . Dual-energy X-ray absorptiometry and body composition ［J］. Nutrition ， 1996 ， 12 （ 1 ）： 45 - 51 .

ZEYTINOGLU M ， JAIN R K ， VOKES T J . Vertebral fracture assessment：Enhancing the diagnosis，prevention and treatment of osteoporosis ［J］. Bone ， 2017 ， 104 ： 54 - 65 .

VON ELM E ， ALTMAN D G ， EGGER M ， et al . The strengthening the reporting of observational studies in epidemiology（STROBE） statement：Guidelines for reporting observational studies ［J］. Prev Med ， 2007 ， 45 （ 4 ）： 247 - 251 .

JU D H ， LIU M J ， ZHAO H Y ， et al . Mechanisms of "kidney governing bones" theory in traditional Chinese medicine ［J］. Front Med ， 2014 ， 8 （ 3 ）： 389 - 393 .

韩梅，王禹毅，牟钰洁，等 . 中医药系统综述报告规范及方法学评价［J］. 中国中西医结合杂志， 2012 ， 32 （ 7 ）： 872 - 874 .

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