Analysis on Characteristics and Prescriptions of Chinese Patent Medicines for Functional Diarrhea on Market

DENG Shuangfei; LI Siyu; SONG Changyue; LIU Caiyu; DING Daiyue; SU Xiaohui; LUO Xiaoqin; ZHAO Haiyu; KONG Xiangying

doi:10.13422/j.cnki.syfjx.20260132

您当前的位置：

首页 >

文章列表页 >

Analysis on Characteristics and Prescriptions of Chinese Patent Medicines for Functional Diarrhea on Market

更新时间：2026-04-30

- Analysis on Characteristics and Prescriptions of Chinese Patent Medicines for Functional Diarrhea on Market
  增强出版
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 32, Issue 11, Pages: 261-268(2026)
- 作者机构：
  
  1.遵义医科大学基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室，贵州遵义； 563003
  2.中国中医科学院中药研究所，北京 100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20260132
  CLC： R277;R285;R289
- Received：12 December 2025，
  
  Revised：2026-03-20，
  
  Accepted：23 March 2026，
  
  Online First：24 March 2026，
  
  Published：05 June 2026
- 稿件说明：
移动端阅览
邓双飞,李思宇,宋常月等.已上市治疗功能性腹泻中成药品种特点及处方分析[J].中国实验方剂学杂志,2026,32(11):261-268.

DENG Shuangfei,LI Siyu,SONG Changyue,et al.Analysis on Characteristics and Prescriptions of Chinese Patent Medicines for Functional Diarrhea on Market[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(11):261-268.
邓双飞,李思宇,宋常月等.已上市治疗功能性腹泻中成药品种特点及处方分析[J].中国实验方剂学杂志,2026,32(11):261-268. DOI： 10.13422/j.cnki.syfjx.20260132.

DENG Shuangfei,LI Siyu,SONG Changyue,et al.Analysis on Characteristics and Prescriptions of Chinese Patent Medicines for Functional Diarrhea on Market[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(11):261-268. DOI： 10.13422/j.cnki.syfjx.20260132.

摘要

目的

该研究聚焦于我国治疗功能性腹泻（FDr）的中成药上市品种及其处方特点，以期为该类药物的合理应用与研发提供支持。

方法

收集已上市治疗FDr的中成药信息，采用Microsoft Excel 2021进行数据整理与统计分析，并借助古今医案云平台（V2.3.9）对规范后的中成药处方进行药物性味归经、用药特点及组方规律分析。

结果

该研究共纳入国内已上市治疗FDr的中成药147种；其中儿童适用品种40种；剂型以丸剂、片剂、胶囊剂为主。筛选得到110个处方，其中治疗脾虚证的品种占比最高；药物使用频次前三分别为甘草、白术、茯苓；药性以温、平为主，药味以辛、甘、苦居多，多归脾、胃经；关联规则分析得到强关联配对集合20组；聚类分析共得到3类核心药物组合。

结论

FDr中成药在临床应用中展现出独特价值，尤其在儿童用药领域潜力显著。但目前仍存在药品说明书适应症表述专业性强、医保目录覆盖范围有限、高级别循证医学与药物经济学证据缺乏等问题。为此，未来应着力构建多层次循证证据体系、提升用药依从性、深化辨证用药规律研究等，从而提升FDr中成药的临床应用价值与科学内涵。

Abstract

Objective

This study focused on the marketed Chinese patent medicines for the treatment of Functional Diarrhea （FDr） in China and their prescription characteristics， in order to provide support for the clinical application and research and development of anti-FDr Chinese patent medicines.

Methods

Collect the information of Chinese patent medicines that have been marketed to treat FDr， use Microsoft Excel 2021 software to conduct preliminary data collation and statistical analysis， and use the ancient and modern medical record cloud platform （V2.3.9） to analyze the standardized Chinese patent medicine prescriptions from the aspects of drug nature and taste， medication characteristics and prescription rules.

Results

147 kinds of FDr Chinese patent medicines were included in this study. There are a total of 40 varieties of FDr Chinese patent medicines suitable for children； The distribution of dosage forms is mainly pills， tablets， and capsules. 110 prescriptions were screened， among which the proportion of Chinese patent medicines for the treatment of spleen deficiency syndrome was the highest； The top three drug use frequency were licorice，

Atractylodes macrocephala

， and

Poria cocos

； The medicinal properties are mainly warm and flat， and the medicinal taste is mostly pungent， sweet and bitter， and most of them belong to the two meridians of the spleen and stomach； The association rules analysis obtains 20 strong association pairing sets； Three drug combinations were obtained by cluster analysis.

Conclusion

FDr Chinese patent medicine shows unique value in clinical application， especially in the field of children. However， there are still problems such as strong professionalism in the indication expression of drug instructions， limited coverage of the medical insurance catalog， and lack of high-level evidence-based medicine and pharmacoeconomic evidence. To this end， in the future， efforts should be made to build a multi-level evidence-based evidence system， improve medication compliance， and deepen research on syndrome-based medication laws， so as to enhance the clinical application value and scientific connotation of FDr Chinese patent medicines.

关键词

Keywords

references

（美）德罗斯曼 . 罗马Ⅳ：功能性胃肠病［M］. 北京：科学出版社， 2016 ： 653 - 654 .

DROSSMAN D A . RomaⅣ：Functional Gastrointestinal Diseases ［M］. Beijing ： Science Press ， 2016 ： 653 - 654 .

ZHAO Y F ， GUO X J ， ZHANG Z S ， et al . Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome：A population-based survey inChina ［J］. PLoS One ， 2012 ， 7 （ 8 ）： e43749 .

马乙腾，邹寒依，谢丹，等 . 基于“无湿不成泻”理论探析健脾化湿法论治功能性腹泻［J］. 实用中医内科杂志， 2025 ， doi： 21.1187.R.20250613.1126.002 http://dx.doi.org/21.1187.R.20250613.1126.002 .

MA Y T ， ZOU H Y ， XIE D ， et al . Exploring the treatment of functional diarrhea with the spleen-strengthening and dampness-resolving method based on the theory of "No dampness，no diarrhea "［J］. J Pract Tradit Chin Intern Med ， 2025 ， doi： 21.1187.R.20250613.1126.002 http://dx.doi.org/21.1187.R.20250613.1126.002 .

Drossman D A . Functional gastrointestinal disorders：History，pathophysiology，clinical features and RomeⅣ ［J］. Gastroenterology ， 2016 ， doi： 10.1053/j.gastro.2016.02.032 http://dx.doi.org/10.1053/j.gastro.2016.02.032 .

张安琪 . 基于数据挖掘探讨李冀教授辨治功能性腹泻的用药规律及经验总结［D］. 哈尔滨：黑龙江中医药大学， 2025 .

ZHANG A Q . Research on the medication rule of professor Li Ji's treatment of functional diarrhea based on data mening ［D］. Harbin ： Heilongjiang University of Chinese Medicine ， 2025 .

李晓彤，李家立，曹志群，等 . 基于16S rRNA测序技术探究参苓白术药膳糊对功能性腹泻脾虚证大鼠肠道菌群的影响［J］. 时珍国医国药， 2023 ， 34 （ 12 ）： 3046 - 3051 .

LI X T ， LI J L ， CAO Z Q ， et al . Investigation of the effect of ginseng and Atractylodes medicinal paste on the intestinal flora of rats with functional diarrhea due to spleen deficiency based on 16S rRNA sequen-cing technology ［J］. Lishizhen Med Mater Med Res ， 2023 ， 34 （ 12 ）： 3046 - 3051 .

吴泱，张翔，叶丹，等 . 香砂六君子汤合四磨汤加减治疗功能性腹泻肝气乘脾证临床研究［J］. 新中医， 2021 ， 53 （ 11 ）： 55 - 58 .

WU Y ， ZHANG X ， YE D ， et al . Clinical study on modified Xiangsha Liujunzi Tang and Simo Tang for functional diarrhea with syndrome of liver Qi over-restricting spleen ［J］. New J Tradit Chin Med ， 2021 ， 53 （ 11 ）： 55 - 58 .

国家药典委员会 . 中华人民共和国药典：一部［M］. 北京：中国医药科技出版社， 2020 .

Chinese Pharmacopoeia Commission . Pharmacopoeia of the People's Republic of China：Volume Ⅰ ［M］. Beijing ： China Medical Science Press ， 2020 .

钟赣生 . 中药学［M］. 北京：中国中医药出版社， 2016 .

ZHONG G S . Chinese Materia Medica ［M］. Beijing ： China Press of Traditional Chinese Medicine ， 2016

中华中医药学会脾胃病分会 . 功能性腹泻中医诊疗专家共识（2023）［J］. 中国中西医结合消化杂志， 2023 ， 31 （ 12 ）： 909 - 914 .

China Association of Chinese Medicine . Expert consensus on traditional Chinese medicine diagnosis and treatment of functional diarrhea（2023）［J］. Chin J Integr Tradit West Med Dig ， 2023 ， 31 （ 12 ）： 909 - 914 .

麻筱金 . 小儿功能性腹泻的中医疗法［J］. 井冈山医专学报， 1997 ， 4 （ 4 ）： 48 - 53 .

MA X J . Traditional Chinese medicine treatment for functional diarrhea in children ［J］. J Jinggangshan Med Coll ， 1997 ， 4 （ 4 ）： 48 - 53 .

刘晖，陈宇静，付乾芳，等 . 我国儿童中成药现状分析及思考［J］. 中国中药杂志， 2024 ， 49 （ 7 ）： 1966 - 1973 .

LIU H ， CHEN Y J ， FU Y F ， et al . Analysis and reflection on current situation of Chinese patent medicine for children in China ［J］. China J Chin Mater Med ， 2024 ， 49 （ 7 ）： 1966 - 1973 .

段炼 . 儿童外用制剂专利分析［J］. 科技与创新， 2018 ， doi： 10.15913/j.cnki.kjycx.2018.10.026 http://dx.doi.org/10.15913/j.cnki.kjycx.2018.10.026 .

DUAN L . Patent analysis of pediatric topical preparations ［J］. Sci Technol Innov ， 2018 ， doi： 10.15913/j.cnki.kjycx.2018.10.026 http://dx.doi.org/10.15913/j.cnki.kjycx.2018.10.026 .

WANG K . Clinical efficacy analysis of compound pediatricantipyretic suppositories in treating pediatric fever convulsions ［J］. Pharm Today ， 2018 ， 28 （ 3 ）： 193 - 195 .

YU K . Current situation and dosage form design ofpharmaceutical preparations for children ［J］. Shanghai Med Pharm J ， 2017 ， 38 （ 15 ）： 91 - 94 .

WANG W ， CHEN Z Y ， CHAl X Y ， et al . Present situation and development strategy of paediatric formulations ［J］. Chin J Pharm ， 2015 ， 46 （ 4 ）： 412 - 417 .

朴艺兰，王汉，巴瑞琴，等 . 中医治疗功能性腹泻的研究概况［J］. 内蒙古中医药， 2025 ， 44 （ 1 ）： 152 - 156 .

PIAO Y L ， WANG H ， BA R Q ， et al . Research overview of traditional Chinese medicine in the treatment of functional diarrhea ［J］. Nei Mongol J Tradit Chin Med ， 2025 ， 44 （ 1 ）： 152 - 156 .

袁春梅 . 罗伟生教授治疗功能性腹泻的用药规律及经验总结［D］. 南宁：广西中医药大学， 2024 .

YUAN C M . Professor LUO Weisheng focuses on the medication rules and experience summary of treating functional diarrhea ［D］. Nanning ： Guangxi University of Chinese Medicine ， 2024 .

李文静 . 基于数据挖掘总结邓厚波教授治疗功能性腹泻用药规律研究［D］. 长春：长春中医药大学， 2023 .

LI W J . Study on the medication rule of professor DENG Houbo in the treatment for functional diarrhea based on data mining ［D］. Changchun ： Changchun University of Chinese Medicine ， 2023 .

廖慧玲，米绍平，汪世强 . 汪世强教授调理脾胃在儿科中的运用［J］. 内蒙古中医药， 2015 ， 34 （ 1 ）： 36 .

LIAO H L ， MI S P ， WANG S Q . Professor WANG Shiqiang's application of spleen and stomach regulation in pediatrics ［J］. NeiMongol J Tradit Chin Med ， 2015 ， 34 （ 1 ）： 36 .

梁宇光，丁倩，王谦，等 . 政策驱动下中国儿童用药发展成效分析［J］. 中国新药杂志， 2025 ， 34 （ 13 ）： 1345 - 1350 .

LIANG Y G ， DING Q ， WANG Q ， et al . An analysis of the development achievements in pediatric drugs in China driven by policy ［J］. Chin J New Drugs ， 2025 ， 34 （ 13 ）： 1345 - 1350 .

丁黛悦，宋常月，邓双飞，等 . 已上市治疗慢性胃炎中成药的品种特点与规律分析［J］. 中国实验方剂学杂志， 2026 ， 32 （ 11 ）： 252 - 260 .

DING D Y ， SONG C Y ， DENG S F ， et al . Analysis of variety characteristics and patterns of marketed traditional Chinese patent medicines for treating chronic gastritis ［J］. Chin J Exp Tradit Med Form ， 2026 ， 32 （ 11 ）： 252 - 260 .

宋常月，邓双飞，李思宇，等 . 已上市治疗流产中成药应用特征与规律研究［J］. 中国实验方剂学杂志， 2026 ， 32 （ 11 ）： 244 - 251 .

SONG C Y ， DENG S F ， LI S Y ， et al . Application characteristics and patterns of marketed traditional Chinese patent medicines for treating abortion ［J］. Chin J Exp Tradit Med Form ， 2026 ， 32 （ 11 ）： 244 - 251 .

李思宇，邓双飞，丁黛悦，等 . 已上市治疗类风湿关节炎中成药品种特点及处方分析［J］. 中国实验方剂学杂志， 2026 ， 32 （ 11 ）： 269 - 276 .

LI S Y ， DENG S F ， DING D Y ， et al . Study on characteristics and prescription analysis of marketed chinese patent medicines for rheumatoid arthritis ［J］. Chin J Exp Tradit Med Form ， 2026 ， 32 （ 11 ）： 269 - 276 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Characteristics and Prescription Analysis of Marketed Chinese Patent Medicines for Rheumatoid Arthritis

Analysis of Variety Characteristics and Patterns of Marketed Traditional Chinese Patent Medicines for Treating Chronic Gastritis

Application Characteristics and Patterns of Marketed Traditional Chinese Patent Medicines for Treating Abortion

Related Author

LI Siyu

DENG Shuangfei

DING Daiyue

SONG Changyue

SU Xiaohui

KONG Xiangying

DING Daiyue

SONG Changyue

Related Institution

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

School of Chinese Materia Medica， Yunnan University of Chinese Medicine

Institute of Chinese Materia Medica， China Academy of Chinese Medical Science

Xiyuan Hospital， China Academy of Chinese Medical Science

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰