Serum Pharmacochemistry Study of Dihuang Yinzi

GUO Si-qun; ZHU Kui-yuan; XIE Ning; JIANG Yuan-yuan; ZHANG Ning

doi:CNKI:11-3495/R.20110221.1133.005

您当前的位置：

首页 >

文章列表页 >

Serum Pharmacochemistry Study of Dihuang Yinzi

更新时间：2024-01-04

- Serum Pharmacochemistry Study of Dihuang Yinzi
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 8, Pages: 74-78(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：CNKI:11-3495/R.20110221.1133.005
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
GUO Si-qun, ZHU Kui-yuan, XIE Ning, et al. Serum Pharmacochemistry Study of Dihuang Yinzi[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 74-78.
DOI：

GUO Si-qun, ZHU Kui-yuan, XIE Ning, et al. Serum Pharmacochemistry Study of Dihuang Yinzi[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 74-78. DOI： CNKI:11-3495/R.20110221.1133.005.

摘要

目的: 对经方地黄饮子的血清药物化学进行研究。方法: 利用UPLC-ESI-MS对地黄饮子体外样品及灌胃给予地黄饮子或单味药后家兔血清样品进行分析

比较各样品分析结果

确认地黄饮子的血中移行成分、代谢产物及其生药来源。结果: 灌胃给予地黄饮子后家兔血清中发现9个血中移行成分

其中7个为新产生的代谢产物

2个为地黄饮子所含的原型成分

分别由五味子、远志、石菖蒲、巴戟天、山茱萸、肉苁蓉、附子、麦冬贡献产生。结论: 初步确定了地黄饮子的血中移行成分及代谢产物

对其进行深入的研究

将助于阐明地黄饮子的有效成分及作用机制。

Abstract

Objective: To investigate the parameters of serum pharmacochemistry of Dihuang Yinzi. Method: Using UPLC-ESI-MS method

the chromatograms of rabbit serum samples after oral administration of Dihuang Yinzi and crude drugs were analyzed and compared with control rabbit serum. Result: Nine constituents absorbed into the blood after administration of Dihuang Yinzi were detected

including seven metabolites and two original form compounds. Conclusion: The constituents absorbed into blood and their metabolites of Dihuang Yinzi were identified preliminary. This study is conducive to the exploration of bioactive constituents of Dihuang Yinzi.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on Serum Pharmacochemistry of Xiefei Pingchuanling Extract

In Vitro and in vivo Component Identification of Danshenyin Based on UPLC-Q-TOF-MS/MS

Dihuang Yinzi Improves Cognitive Function of Mouse Model of Learning and Memory Impairments by Regulating Synaptic Plasticity via SIRT2

Comparative Analysis of Serum Pharmacochemistry of Alismatis Rhizoma Before and After Salt Processing Based on UPLC-Q-TOF-MS

Analysis on Material Basis of Anti-COPD Effect of Euphorbia helioscopia Based on Serum Pharmacochemistry and Network Pharmacology

Related Author

LIU Ju-yan

CHAO Jian-guo

GU Wei

SHAN Jin-jun

WANG Yue-jia

ZHANG Sitong

HU Xianrun

LIU Wenkang

Related Institution

Key Laboratory for Standardization of Chinese Medicines，Ministry of Education， Shanghai Key Laboratory for Compound Chinese Medicines，Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines，Institute of Materia Medica & Neuroscience Center，Chinese Academy of Medical Sciences and Peking Union Medical College

Shanxi Key Laboratory of Chinese Medicine Encephalopathy，National International Joint Research Center for Molecular Chinese Medicine，Shanxi University of Chinese Medicine

Beijing City University

Tianjin University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰