Protective Effect of Different Extracts of  on Endotoxin Induced Systemic Inflammatory Response Syndrome in Mice

LI Yu-jie; Yang Qing; YANG Lan; LIU Xiao-ni; WENG Xiao-gang; CHEN Yin; ZHANG Dong; MEN Wei; ZHU Xiao-xing

doi:CNKI:11-3495/R.20110221.1159.010

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Protective Effect of Different Extracts of on Endotoxin Induced Systemic Inflammatory Response Syndrome in Mice

更新时间：2024-01-04

- Protective Effect of Different Extracts of on Endotoxin Induced Systemic Inflammatory Response Syndrome in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 8, Pages: 187-189(2011)
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- DOI：CNKI:11-3495/R.20110221.1159.010
  CLC：
- Published：2011
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LI Yu-jie, Yang Qing, YANG Lan, et al. Protective Effect of Different Extracts of on Endotoxin Induced Systemic Inflammatory Response Syndrome in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 187-189.
DOI：

LI Yu-jie, Yang Qing, YANG Lan, et al. Protective Effect of Different Extracts of on Endotoxin Induced Systemic Inflammatory Response Syndrome in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 187-189. DOI： CNKI:11-3495/R.20110221.1159.010.

摘要

目的: 通过建立小鼠全身炎症反应综合征(SIRS)模型

研究中药贯众的不同品种对SIRS模型的保护作用。方法: BALB/c小鼠随机分为空白组、模型组和贯众醇提物高、中、低剂量(4.68

2.34

1.17 g ·kg-1)组

预防给药7 d后造模

5 h后检测小鼠肛温、呼吸频率、肺湿重/干重比、外周血白细胞计数以及糖脂代谢情况。结果: ip 内毒素(LPS) 6 mg ·kg-1可致小鼠体温明显降低

外周血白细胞数减少

肺组织充血水肿

糖脂代谢水平降低。紫萁贯众和荚果蕨贯众可不同程度地影响LPS所致小鼠的肛温、肺干湿重、血清胆固醇和外周血白细胞数等异常改变

其中紫萁贯众作用更为明显。结论: ip LPS致小鼠SIRS模型成立

紫萁贯众和荚果蕨贯众醇提物对内毒素致小鼠SIRS有一定保护作用。

Abstract

Objective: To study the protective effect of Dryopteris crassirhizoma on systemic inflammatory response syndrome (SIRS) through establishing the mouse model of SIRS. Method: BALB/c mice were randomly devided into several groups

the normal control group

the LPS model group and the different doses of Dryopteris crassirhizoma extract groups(4.68

2.34

1.17 g ·kg-1).The rectal temperature

respiratory rate

wet and dry lung weight ratio

WBC

the level of glucose and lipid metabolism were determined before and after treatment. Result: Intra-peritoneal injection of LPS 6 mg ·kg-1 could significantly lower the body temperature

reduce WBC

make the lung congestion and edema

reduce the level of glucose and lipid metabolism. Osmunda japonica and Matteuccia struthiopteris could raise the low temperature and reduction of WBC caused by LPS

improve the abnormal serum choleterol. Conclusion: O. japonica and M. struthiopteris have marked effect in protecting LPS caused SIRS.

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Related Institution

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