YU Cai-na, FAN Ying, LIN Shu-ru. Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 193-196.
DOI:
YU Cai-na, FAN Ying, LIN Shu-ru. Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 193-196. DOI: CNKI:11-3495/R.20110303.1348.006.
Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury
Objective: To investigate the effect of Qifu Decoction on heart function of adriamycin-induced cardiac injury in a rat model
and to discuss the mechanism. Method: Heart function was measured by ECG instrument
the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) were detected
and the content of lipid peroxidation product malondialdehyde(MDA) were checked by chemical colorimetric method. Result: Compared with the normal group
the heart rate of the rats in the model group was slowed down
the sum of QRS voltage decreased
Q-T interval extended
all with statistically significance(P<0.05). Arrhythmia appeared in a few individuals. Compared with the model group
the heart rate of the rats in Qifu Decoction group and Chinese herb control group was speeded up
the sum of QRS voltage increased
Q-T interval shortened
all with statistically significance(P<0.05). Compared with the normal group
the activities of SOD and GSH-Px were weakened
and the content of MDA increased in the model group
Qifu Decoction group and Chinese herb control group
all with statistically significance(P<0.05). Compared with the model group
the activities of SOD and GSH-Px were strengthened
and the content of MDA decreased in Qifu Decoction group and Chinese herb control group
all with statistically significance(P<0.05). Conclusion: Qifu Decoction can protect the heart from adriamycin in the rat model. Its mechanism may be related with antioxidant stress.
Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
Effect of Qifu Decoction on Adriamycin-induced Cardiac Apoptosis in Rat
Astragali Radix-Salviae Miltiorrhizae Radix et Rhizoma Ameliorates Myocardial Ischemia-reperfusion Injury in Rats via FUNDC1-dependent Mitophagy
Shengxiantang Alleviates Idiopathic Pulmonary Fibrosis in Rats by Regulating Oxidative Stress to Inhibit PANoptosis
Related Author
FAN Ying
CAI Li-ping
XU Dan
YU Cai-na1
FAN Ying1
LIN Shu-ru2
WANG Zhe
WANG Guoliang
Related Institution
Prescription Department,Liaoning University of Traditional Chinese Medicine
Laboratory of Molecular Biology,Liaoning University of Traditional Chinese Medicine
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Xiyuan Hospital, China Academy of Chinese Medical Sciences