Effects of Guizhi Fuling Capsule on Quantity of CD4 T Lymphocytes and Cytotoxic Activity of NK Cells in Spleen of Rats with Endometriotics

HU Chun-ping; HU Ting-ting; CAI Xue-ting; WANG Zhi-gang; LU Wu-guang; WAN Gui-ping; CAO Peng

doi:CNKI:11-3495/R.20110314.0943.014

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Effects of Guizhi Fuling Capsule on Quantity of CD4 T Lymphocytes and Cytotoxic Activity of NK Cells in Spleen of Rats with Endometriotics

更新时间：2024-01-04

- Effects of Guizhi Fuling Capsule on Quantity of CD4 T Lymphocytes and Cytotoxic Activity of NK Cells in Spleen of Rats with Endometriotics
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 9, Pages: 145-148(2011)
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- DOI：CNKI:11-3495/R.20110314.0943.014
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- Published：2011
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HU Chun-ping, HU Ting-ting, CAI Xue-ting, et al. Effects of Guizhi Fuling Capsule on Quantity of CD4 T Lymphocytes and Cytotoxic Activity of NK Cells in Spleen of Rats with Endometriotics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 145-148.
DOI：

HU Chun-ping, HU Ting-ting, CAI Xue-ting, et al. Effects of Guizhi Fuling Capsule on Quantity of CD4 T Lymphocytes and Cytotoxic Activity of NK Cells in Spleen of Rats with Endometriotics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 145-148. DOI： CNKI:11-3495/R.20110314.0943.014.

摘要

目的: 观察桂枝茯苓胶囊对子宫内膜异位症(EMs)模型大鼠脾脏CD4+T淋巴细胞数和NK细胞杀伤活性的影响。方法: 改进制作大鼠子宫内膜异位症动物模型

ig桂枝茯苓胶囊0.256

1.024 g ·kg-1

28 d后取脾脏

分离淋巴细胞

采用流式细胞分析术测定大鼠脾脏中CD4+ T淋巴细胞数;将分离的NK细胞与K562细胞共孵育后

MTT法检测其杀伤活性。结果: 低剂量组CD4+ T淋巴细胞数比模型组提高19.0%

NK细胞杀伤活性提高54.1%

具有显著意义。结论: 桂枝茯苓胶囊可显著提高CD4+ T淋巴细胞数和NK细胞杀伤活性。

Abstract

Objective: To observe the effects of Guizhi Fuling Capsule on the quantity of CD4+ T lymphocytes and the cytotoxic activity of NK cells in spleen of with rats endometriosis. Method: Rat model of endometriosis was created by self-transplant

and then administrated with 0.256 or 1.024 g ·kg-1 Guizhi Fuling Capsule orally for 28 days. Lymphocytes and NK cells were separated from the spleen. The quantity of CD4+ T lymphocytes was measured by flow cytometry. The cytotoxic activity of NK cells were tested by MTT assay while incubated with K562 cells. Result: CD4+ T lymphocytes were 19.0% higher in low-dose group than model group. Compared with model group

the cytotoxic activity of NK cells in low-dose group increased about 0.5 fold. Conclution: The quantity of CD4+ T lymphocytes and the cytotoxic activity of NK cells in EMs can be significantly increased by Guizhi Fuling Capsule.

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