Shuxuetong Injection on Renin-angiotensin System and its Activity Effects for Treating Geriatric Hypertension

QUAN Yi-hong; QIN Jie; FAN Yi; ZHEN Guo-hua; LEI Xue-jian; WEN Pang; PAN Hong

doi:CNKI:11-3495/R.20110314.0944.015

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Shuxuetong Injection on Renin-angiotensin System and its Activity Effects for Treating Geriatric Hypertension

更新时间：2024-01-04

- Shuxuetong Injection on Renin-angiotensin System and its Activity Effects for Treating Geriatric Hypertension
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 9, Pages: 242-245(2011)
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- DOI：CNKI:11-3495/R.20110314.0944.015
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- Published：2011
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QUAN Yi-hong, QIN Jie, FAN Yi, et al. Shuxuetong Injection on Renin-angiotensin System and its Activity Effects for Treating Geriatric Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 242-245.
DOI：

QUAN Yi-hong, QIN Jie, FAN Yi, et al. Shuxuetong Injection on Renin-angiotensin System and its Activity Effects for Treating Geriatric Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 242-245. DOI： CNKI:11-3495/R.20110314.0944.015.

摘要

目的: 观察疏血通注射液对老年高血压患者立位肾素(PRA)活性、血管紧张素Ⅱ(AngⅡ)及内皮素(ET)、一氧化氮(NO)含量的影响

探讨疏血通注射液的降压机制。方法: 高血压病患者随机分为治疗组40例和对照组36例。治疗组采用疏血通注射液、卡托普利结合治疗

对照组单用卡托普利治疗

14 d为1疗程。观察治疗前后患者血压、血浆PRA

AngⅡ

NO水平及血脂、血液流变学指标的变化。结果: 治疗组血浆ET

AngⅡ水平降低

PRA

NO水平升高(P<0.01)

血浆ET

PRA水平变化与对照组比较有显著性差异(P<0.05);血浆AngⅡ水平变化与对照组比较无显著性差异。治疗组血液流变学及血脂水平较治疗前明显改善

与对照组比较差异显著(P<0.01)。结论: 疏血通注射液能使老年高血压患者肾素-血管紧张素系统(RAS)及其活性有明显改善

提高NO水平

降低血浆 ET

AngⅡ含量

改善血液流变性、降低血脂及调节内皮功能

有效降低血压。

Abstract

Objective: Through observing the treatment of geriatric hypertension by Shuxuetong injection on the activity of PRA

the content of AngⅡ

to investigate the mechanism of Shuxuetong on antihypertension. Method: All of the hypertension patients were randomized into treating group (n=40)and control group (n=36).The two groups were all treated with Captopril.The treating group was given Shuxuetong injection additionally.The total course was 14 days.We observed the change of PRA

AngⅡ

NO and the other biochemical data before and after the treatment. Result: The level of ET and AngⅡwas descending

and the level of PRA

NO was ascending in the treating group(P<0.01).There was a significant difference compared with the control group for the level of ET

PRA(P<0.05).The difference of the level of AngⅡwas insignificant.The hemorheological parameters and lipids in the treating group were improved obviously

and the difference was significant compared with the control group(P<0.01). Conclusion: Shuxuetong injection could improve renin-angiotensin system for geriatric hypertension

raise the level of NO

lower the content of ET and AngⅡ

improve the hemorheological parameters and the function of lipids and endothelium

lower blood pressure effectively.

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