Objective: To study the effect of formulation factors of Fufang Danshen pulsed tablets on release behavior in vitro

and to determine the best tablet core formulation and the coating formulation. Method: Three constituents of Fufang

total phenolic acids

ginsenoside Rg1 and borneol were taken as the index to study the effect of different types and usage amount of disintegrants

diluents

adhesives on release behavior in tablet core formulation. The same study was carried out on the effect of plasticizers and pore-forming agent in the coating formulation. Result: Low-substituted hydroxypropylcellulose (L-HPC) was selected as disintegrants

meanwhile microcrystalline cellulose (MCC) was as diluent with PVP ethanol solution as adhesive in tablet core formulation. Ethyl cellulose (EC) was employed as the main coating materials. And triethyl citrate (TEC) and lactose were chosen as plasticizers and pore-forming agent in the coating formulation respectively. Release curves of index constituents in samples prepared according to the best formulation could be fitting by Weibull distribution model. Conclusion: Prepared Fufang Danshen pulsed tablets has desired pulsatile release behavior

which laid the foundation for further research.