Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by -galactosamine in Mice

YANG Xin; WANG Li-hui; LUO Xu-yan; FU Shu-Jie; HUANG Ren-bin

doi:CNKI:11-3495/R.20110321.1134.010

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Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by -galactosamine in Mice

更新时间：2024-01-04

- Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by -galactosamine in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 10, Pages: 152-154(2011)
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- DOI：CNKI:11-3495/R.20110321.1134.010
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- Published：2011
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YANG Xin, WANG Li-hui, LUO Xu-yan, et al. Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by -galactosamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 152-154.
DOI：

YANG Xin, WANG Li-hui, LUO Xu-yan, et al. Protection of Yigan Zhuanyin Granules on Acute Liver Injuries Induced by -galactosamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 152-154. DOI： CNKI:11-3495/R.20110321.1134.010.

摘要

目的: 研究乙肝转阴颗粒(YGZYDG)对D-半乳糖胺(D-GalN)所致小鼠急性肝损伤的保护作用

并探讨其作用机制。方法: 观测YGZYDG(1.68

0.84

0.42 g ·kg-1)连续ig 7 d

对 ip D-GalN(0.8 g ·kg-1)致急性肝损伤模型小鼠血清门冬氨酸氨基转移酶(AST)

丙氨酸氨基转移酶(ALT)

碱性磷酸酶(AKP)活性

血清白蛋白(Alb)含量

总抗氧化能力(T-AOC)以及肝组织丙二醛(MDA)含量

超氧化物歧化酶(SOD)活性的影响。结果: 与模型组比较

YGZYDG能降低血清AST

ALT和AKP的活性及肝组织MDA含量;提高血清Alb含量

T-AOC能力和肝组织SOD活性(P<0.01或P<0.05);能够减轻肝细胞损伤程度。结论: YGZYDG对D-半乳糖胺所致的急性肝损伤具有保护作用

其机制可能与其抗氧自由基、抑制脂质过氧化作用有关。

Abstract

Objective: To study the effect of Yigan Zhuanyin granules(ZGZYG)on acute liver injuries induced by D-galactosamine(D-GalN)in mice and its mechanism. Method :After oral administration of YGZYG(1.68

0.84

0.42 g ·kg-1)for seven days

the mice were abdominally administrated D-GalN(0.8 g ·kg-1)to induce liver injury. The activities of AST

ALT and ALP

the content of Alb

the ability of T-AOC in serum

the content of MDA

and the activity of SOD in liver tissue were investigated. Result: Compared with model group

the activities of AST

ALT and AKP

and the content of MDA in the treatment groups were decreased;while the content of Alb

the ability of T-AOC

and the activity of SOD were increased(P<0.01 or P<0.05). The degree of hepatic injury was lessened. Conclusion: YGZYG has protective effect on acute liver injury induced chemically. The mechanism may be related to attenuating free radical and inhibiting the effect on lipid peroxidation.

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