Objective: To investigate the fungicidal activity of the substance in peritoneal exudates from inflammatory fluid of abdominal cavity in rats infected by Candida albicans. Method :The model of severe abdominal cavity inflammation was prepared by intraperitoneal administration of C. albicans to rats. The peritoneal exudates were collected and the fungicidal activity of peritoneal exudation supernatant were determined. Result: The peritoneal exudation supernatant collected at 24 h possessed the most potent fungicidal activity. The fungicidal activity of 80% peritoneal exudation supernatant collected at 24 h was dramatically declined after incubated in 56 ℃for 10 min. C. albicans morphology changed gradually and their color turned dark

their thalline was shrinked and their cell wall was degraded after treated by peritoneal exudation supernatant for 30 min

C. albicans color turned dark further

the thalline was smaller further

and then was expired due to disruption lastly. Conclusion: The supernatant of imflammatory peritoneal exudates from abdominal cavity inflammation rat models infected by C. albicans possess potent fungicidal activity against fungus

the substances may be unknown fungicidal protein/ peptide.