FANG Min-feng, FU Zhi-ling, WANG Qi-lin, et al. Effect of Cream Processing on Metabolism and Tissue Distribution of Bitter Almond in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 132-137.
DOI:
FANG Min-feng, FU Zhi-ling, WANG Qi-lin, et al. Effect of Cream Processing on Metabolism and Tissue Distribution of Bitter Almond in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 132-137. DOI: CNKI:11-3495/R.20110321.1139.018.
Effect of Cream Processing on Metabolism and Tissue Distribution of Bitter Almond in Rat
Objective: To study the influence of cream processing on metabolism and tissue distribution of bitter almond in rat. Method :Amygdalin was set as control group given by mainline
bitter almond and its cream product were given to SD rats by oral
HPLC was employed for the determination of amygdalin and its metabolite in blood
heart
liver
spleen
lung and kidney
and LC-MSn was used for further identification of the metabolite structure. Result: Amygdalin was distributed in the tissues as prototype after given by mainline
while in the groups of oral administration
it was distributed as the secondary metabolite prunasin;and compared to bitter almond crude material
the time of prunasin distribution in the tissues was prolonged after cream processing
and showed two peaks phenomenon. Conclusion: Cream processing have a significant effect on the metabolism and tissue distribution of bitter almond
this provides information for the mechanism of bitter almond’s processing.
Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata
Material Basis and Its Distribution in vivo of Qili Qiangxin Capsules Analyzed by UPLC-Q-Orbitrap-MS
Effect of Borneol on Pharmacodynamics,Pharmacokinetics and Brain Tissue Distribution of Main Active Ingredients of Jiaotaiwan in Depression Model Rats
Distribution of Nardosinone and Its Metabolites in Rats Analyzed by UPLC-Q-Exactive Orbitrap MS/MS
Analysis of Chemical Components and Tissue Distribution of Lujiao Formula Based on UPLC-Q-Orbitrap-MS
Related Author
SUN Jing
QI Yunpeng
LI Siyuan
HU Yingbo
ZHONG Linying
CHEN Jianbo
DONG Ling
ZHANG Jianwei
Related Institution
School of Life Sciences,Beijing University of Chinese Medicine
Third Grade Laboratory of Traditional Chinese Medicine(TCM) Preparations,National Administration of TCM,Shuguang Hospital Affiliated to Shanghai University of TCM
Affiliated Hospital of Nanjing University of Chinese Medicine
School of Pharmacy, Hunan University of Chinese Medicine
Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China,Southwest Minzu University