Objective: To investigate the influence of Schisandra compound on the function of the hypothalamus-pituitary-adrenal axis

the carbohydrate and blood-lipid metabolism in male rats underwent experimental navigation and strenuous exercise. Method: Thirty-one SD male rats were randomly allocated into three groups

quiet group (group A)

stress control group (group B) and Schisandra Chinensis Fructus compound administration (10 mL ·kg-1

2/d

ig

one week) group (group C). Both group B and C underwent wearing floating with psychological stress

then the corticosterone(CORT)

cholesterol(CHO)

triglyceride(TG)and blood glucose levels of the three groups were measured. At the same time

we excised the pituitary tissue to observe the number of the positive expression of ACTH and NPY cells by immunohistochemistry. Result: ①In group B the plasma glucose level increased ·L-1

P<0.01]

TG and CHO levels decreased significantly compared to group A ·L-1

P<0.01];CHO ·L-1

P<0.05]. In group C

the plasma glucose level increased ·L-1

P<0.05] and TG level decreased significantly compared to group B ·L-1

P<0.05]

but there’s no obviouse difference in serum CHO level(1.83±0.19) mmol ·L-1. ②By immunohistochemistry

we found that in group C the number of the positive cells of ACTH and NPY in the pituitary tissue were increased compared to group B. However

the number of the positive cells of ACTH and NPY in both two groups were less than group A. ③In group C

the number of the lipid granules increased obviously compared with group B

which is less than that in group A under electron microscope. Conclusion: Schisandra compound has the effects on adjusting serum levels of blood glucose and blood-fat

and can protect the structure of pituitary and adrenocortical cells.