Objective: To research the effects of Jingqianshu granule (JQSG) on the expression of serotonin transporter(5-HTT)of premenstrual syndrome (PMS) model rats with liver-qi stagnation in different brain regions and the mechanism at molecular level. Method : SPF female SD rats were randomly divided into normal control group

model group

JQSG group(10 g ·kg-1)and fluoxetine group(0.002 5 g ·kg-1).The PMS model rats with liver-qi stagnation were induced by bondaging the limbs. Drugs were given for 5 days

and the effects were evaluated by open-field test and sucrose preference test. We analyzed the expression of 5-HTT in hippocampus and hypothalamus by the method of RT-PCR and Western blot. Result : Compared with the model group

the score of open-field and saccharine preference index of JQSG and fluoxetine group were markedly increased (P<0.05

P<0.01). The treatment could improve the expression of 5-HTT in hippocampus and hypothalamus (P<0.05

P<0.01)and the two treated groups showed no significant difference. Conclusion : JQSG can regulate the 5-HTT expression level in hippocampus and hypothalamus in model rats

which may be one of the mechanisms responsible for treating PMS with liver-qi stagnation.