Influence of Xiefei Pingchuanling and Its Decomposed Formulas on Serum Endotoxin and Tumor Necrosis Factor-α in Rat Model with 'Interior and Exterior Relationship between Lung and Large Intestine’
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Influence of Xiefei Pingchuanling and Its Decomposed Formulas on Serum Endotoxin and Tumor Necrosis Factor-α in Rat Model with 'Interior and Exterior Relationship between Lung and Large Intestine’
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 14, Pages: 136-139(2011)
NI Xin-qiang, HAN Xin-min. Influence of Xiefei Pingchuanling and Its Decomposed Formulas on Serum Endotoxin and Tumor Necrosis Factor-α in Rat Model with 'Interior and Exterior Relationship between Lung and Large Intestine’[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 136-139.
DOI:
NI Xin-qiang, HAN Xin-min. Influence of Xiefei Pingchuanling and Its Decomposed Formulas on Serum Endotoxin and Tumor Necrosis Factor-α in Rat Model with 'Interior and Exterior Relationship between Lung and Large Intestine’[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 136-139. DOI: CNKI:11-3495/R.20110524.1335.006.
Influence of Xiefei Pingchuanling and Its Decomposed Formulas on Serum Endotoxin and Tumor Necrosis Factor-α in Rat Model with 'Interior and Exterior Relationship between Lung and Large Intestine’
Objective: To observe the influence of Xiefei Pingchuanling and its decomposed formulas on serum changes of endotoxin (ET) and tumor necrosis factor-α (TNF-α) in model rats with 'interior and exterior relationship between the lung and the large intestine’. Method :Seventy SD rats were randomly divided into 7 groups: the normal group
the model group
the unhitch group
the Sanao group
the Santong group
the Sanhuo group and the Xiefei Pingchuanling group. The rat model of 'interior and exterior relationship between the Lung and the Large intestine’ was established to intestinal obstruction by incomplete ligation of the rectum in vitro. The rats in model group were killed after 3 days. The Sanao group was treated by Sanao decoction with the crude drug dosage of 3.92 g ·kg-1 intragastrically
the Santong group was treated by Santong decoction with the crude drug dosage 7.11 g ·kg-1 intragastrically
the Sanhuo group was teated by Sanhuo decoction with the crude drug dosage 10.54 g ·kg-1 intragastrically
the Xiefei Pingchuanling group was treated by Xiefei Pingchuanling decoction with the crude drug dosage 16.66 g ·kg-1 intragastrically. The rats were killed after 3 days of ig. The changes in serum ET and TNF-α were observed to investigate the interventional effect of Xiefei Pingchuanling and Its decomposed formulas. Result : The serum levels of ET and TNF-α were increased significantly in the model group(P<0.01). The serum levels of ET and TNF-α were decreased in the other groups compared with the models(P<0.01). The synergies existed in some groups. Conclusion :Xiefei Pingchuanling and its decomposed formulas can protect the lung tissue
alleviate pathological change and prevent the tissue of the model rats from endotoxemia.
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