LI Shu-wen, HU Lv-jiang, WU Qing-he. Effect of Suoquanwan on HPA in Rats with Kidney Deficiency and Diuresis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 125-127.
DOI:
LI Shu-wen, HU Lv-jiang, WU Qing-he. Effect of Suoquanwan on HPA in Rats with Kidney Deficiency and Diuresis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 125-127. DOI: CNKI:11-3495/R.20110622.1305.007.
Effect of Suoquanwan on HPA in Rats with Kidney Deficiency and Diuresis
Objective: To investigate the mechanism of nourishing kidney and reducing urine by investigating the regulative action of Suoquanwan to HPA. Method: The rat model of kidney deficiency and diuresis was established by adenine (150 mg·kg-1
ig 4 weeks)
From the second week after the model establishment
the treatments were ig given
including Suoquanwan (1.170
0.585
0.293 g·kg-1)
Jinsuo Gujin Wan (0.968 g·kg-1). The contents of CRH
ACTH
cAMP in blood in model group
Suoquanwan group
Jinsuo Gujin Wan group and controll group were determined with ELISA and RIA technology
and also the hypophysis index and adrenal gland index were calculated. Result: Compared with the model group
Suoquanwan could remarkedly increase the contents of CRH
ACTH
cAMP in blood in rats with kidney deficiency and diuresis and improve the hypophysis exponent and adrenal gland exponent. Conclusion: Suoquanwan can enhance the action of body adjusting water metabolize by coordinating the function of HPA.The results of the experiment expound the mechanism of nourishing the kidney and reducing urine of Souquan Wan from the point of view of endocrine.
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Spectrum-effect Relationship of Different Extract Parts of Suoquanwan Constituted with Salt-processed Alpiniae Oxyphyllae Fructus on Arresting Polyuria
The Experimental Study on the mRNA Expression of CYP11B2 in Rat with Kidney Deficiency and Diuresis Induced by Adenine
Related Author
Jie LI
Qing-ke CUI
Hua LI
Fei-fei LI
CAO Hong-ying
HUANG Ping
LI Shu-wen
LI Meng-qi
Related Institution
Shanghai University of Traditional Chinese Medicine