Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer

ZHAO Hong-ye; CAO Jun; WANG Yue-fei; HE Ling-ju; ZHOU Li; LU Chang-zhu; WANG Bin

doi:CNKI:11-3495/R.20110705.1022.001

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Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer

更新时间：2024-01-04

- Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 17, Pages: 213-215(2011)
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- DOI：CNKI:11-3495/R.20110705.1022.001
  CLC：
- Published：2011
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ZHAO Hong-ye, CAO Jun, WANG Yue-fei, et al. Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 213-215.
DOI：

ZHAO Hong-ye, CAO Jun, WANG Yue-fei, et al. Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 213-215. DOI： CNKI:11-3495/R.20110705.1022.001.

摘要

目的: 观察溃疡平对乙酸性胃溃疡大鼠胃黏膜血流量(GMBF)及血清内皮素-1(ET-1)和一氧化氮(NO)含量的影响。方法: 采用改良Okabe法制备大鼠慢性乙酸胃溃疡模型

随机分为:正常组、模型组、溃疡平低、中、高剂量组(1.40

2.80

5.60 g ·kg -1

ig)和盐酸雷尼替丁组(2.83×10-2g ·kg -1

ig)6组。给药14 d后

运用MP150多道生理记录系统中的LDF100C激光多普勒血流测定模块测定溃疡周边部的GMBF;ELISA法检测血清ET-1的含量;硝酸盐还原酶法检测血清NO含量。结果: 与模型组相比

溃疡平高剂量组GMBF明显增多(P<0.05)

血清ET-1含量明显降低(P<0.01)

血清NO含量明显升高(P<0.05);与盐酸雷尼替丁组相比

溃疡平高剂量组GMBF明显增多(P<0.05)

血清ET-1含量明显降低(P<0.01)

血清NO含量明显升高(P<0.05)。结论: 溃疡平刺激NO的合成和释放

反馈性抑制ET-1的释放

从而增加GMBF

这可能是其加速胃溃疡愈合和改善溃疡愈合质量(QOUH)的作用机制之一。

Abstract

Objective: To investigate the effect of traditional chinese medicine Kuiyangping on gastric mucosal blood flow(GMBF) and the serum concentration of endothelin-1(ET-1) and nitric oxide(NO) rats with in acetic acid-induced gastric ulcer(GU). Method: The ulcer model in rats was prepared with Okabe’s method with some modifications. The rats were randomly divided into 6 groups:normal control group

model group

low

middle and high-dose of Kuiyangping groups(1.4

2.8

5.6 g ·kg-1

ig) and ranitidine hydrochloride group(2.83×10-2g ·kg -1

ig). After the 14 days treatment

GMBF of the mucosa around the GU were measured by the LDF100C of MP150 BIOPAC System. We also determined the serum concentration of ET-1 by ELISA

and determined the serum concentration of NO by nitrate reductase one step method. Result: Compared with model group

GMBF was higher(P<0.05)

the serum concentration of ET-1 was lower(P<0.01) and NO was higher(P<0.05) significantly in high-dose of Kuiyangping group. Compared with ranitidine hydrochloride group

GMBF was higher(P<0.05)

the serum concentration of ET-1 was lower(P<0.01) and NO was higher(P<0.05) significantly in high-dose of Kuiyangping group. Conclusion: Kuiyangping could promote the synthesis and release of NO

however

NO could inhibit the release of ET-1.So Kuiyangping could increase the GMBF. Which may be one of the mechanisms of Kuiyangping to promote the healing of gastric ulceration and improve quality of ulcer healing.

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