Strengthening Yang Action of Yangxin Tiaogan Yishen Decoction in Catrated Male Rats

REN Ling-yan; HUANG Xue-kuan; HAN Zhi-gang

doi:CNKI:11-3495/R.20110705.1022.002

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Strengthening Yang Action of Yangxin Tiaogan Yishen Decoction in Catrated Male Rats

更新时间：2024-01-04

- Strengthening Yang Action of Yangxin Tiaogan Yishen Decoction in Catrated Male Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 17, Pages: 216-218(2011)
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- DOI：CNKI:11-3495/R.20110705.1022.002
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- Published：2011
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REN Ling-yan, HUANG Xue-kuan, HAN Zhi-gang. Strengthening Yang Action of Yangxin Tiaogan Yishen Decoction in Catrated Male Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 216-218.
DOI：

REN Ling-yan, HUANG Xue-kuan, HAN Zhi-gang. Strengthening Yang Action of Yangxin Tiaogan Yishen Decoction in Catrated Male Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 216-218. DOI： CNKI:11-3495/R.20110705.1022.002.

摘要

目的: 研究养心调肝益肾煎剂壮阳作用及其可能机制。方法: 手术去势造模

造模后第8天对不同实验组分别ig生理盐水(NS)、养心调肝益肾煎剂高、低剂量(50

25 g ·kg-1)、男宝混悬液(0.56 g ·kg-1)

连续用药21 d后测量去势雄鼠附性器官包皮腺、精液囊-前列腺、提肛肌的质量

计算其脏器系数

测量血清睾酮(T)、皮质醇(F)及阴茎海绵体内皮细胞一氧化氮(NO)的含量。结果: 养心调肝益肾煎剂组与模型组比较

有明显增加去势雄鼠包皮腺、精液囊-前列腺、提肛肌脏器系数及血清T、F及阴茎NO含量的作用(P<0.05)

尤以养心调肝益肾煎剂高剂量组更为明显(P<0.05)。结论: 养心调肝益肾煎剂可调节下丘脑-垂体-性腺轴及肾上腺皮质系统功能

具有壮阳作用。

Abstract

Objective: To investigate strengthening yang action of Yangxin Tiaogan Yishen decoction and its possible mechanism. Method: On the 8th days after making castrated model rats by operation

we respectively fed NS

Yangxin Tiaogan Yishen decoction(50

25 g ·kg-1)

Nanbao mixed liquid(0.56 g ·kg-1) into the stomaches of the different groups of male rats for 21 days. Afterwards

the weight of prepputial gland

sperm bladder-prostate

anus levator muscle

content of testosterone(T) and cortisol(F) in blood serum and nitric oxide(NO) content of endothelium cell of penial corpus cavernosum were observed. Result: The indexes of prepputial gland

sperm bladder-prostate

anus levator muscle

and content of T

F and NO were increased

these items of Yangxin Tiaogan Yishen decoction group were higher than these of the model group (P<0.05). The deta in Yangxin Tiaogan Yishen decoction with high dose group were especially remarkable(P<0.05). Conclusion: Yangxin Tiaogan Yishen decoction can adjust lower thalamus-hypophysis-sexual gland axis and adrenal function

and it can strengthen yang action.

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