Protective Effect of Qiju Dihuang Wan on Kidney Injury in Diabetic Rats

CHEN Yu; LI Hua

doi:CNKI:11-3495/R.20110809.1704.002

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Protective Effect of Qiju Dihuang Wan on Kidney Injury in Diabetic Rats

更新时间：2024-01-04

- Protective Effect of Qiju Dihuang Wan on Kidney Injury in Diabetic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 19, Pages: 251-253(2011)
- 作者机构：
- 作者简介：
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- DOI：CNKI:11-3495/R.20110809.1704.002
  CLC：
- Published：2011
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CHEN Yu, LI Hua. Protective Effect of Qiju Dihuang Wan on Kidney Injury in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 251-253.
DOI：

CHEN Yu, LI Hua. Protective Effect of Qiju Dihuang Wan on Kidney Injury in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 251-253. DOI： CNKI:11-3495/R.20110809.1704.002.

摘要

目的: 探讨杞菊地黄丸(QJDH)对糖尿病大鼠肾脏的保护作用及其机制。方法: ip链脲佐菌素建立大鼠糖尿病模型。将32只SD大鼠随机分为正常组、模型组、QJDH高、低剂量组(2

1 g·kg-1)

每组8只。确认造模成功(72 h)后开始ig药物

1次/d

连续14 d。观察大鼠一般情况

测定血糖、肾系数、24 h尿蛋白、血肌酐(SCr)、血尿素氮(BUN)、丙二醛 (malondialdehyde

MDA)、超氧化物歧化酶(superoxide dismutase

SOD)。结果: QJDH能够明显改善糖尿病大鼠一般情况

减少24 h尿蛋白

SCr

BUN

降低肾组织中MDA含量

增强肾组织中SOD活性。QJDH高剂量组与模型组比较有显著性差异(P<0.01)。结论: 杞菊地黄丸能缓解糖尿病大鼠肾组织氧化应激状态

从而减轻糖尿病所引起的肾脏损伤。

Abstract

Objective: To explore the protective effect and mechanism of Qiju Dihuang Wan (QJDH) on kidney in diabetic rats. Method: Rat diabetic model was set up by intraperitoneal injection of streptozotocin. Thirty-two SD rats were randomly divided into normal group

model group

QJDH high and low dose group (2

1 g·kg-1)

and each group contained eight rats. The daily treatments were started at 72 h after model establishment

and lasted for 4 weeks.The general state of rats was observed. Blood sugar

kindey weight/body weight index

24 h urine protein

serum creatinine(SCr)

blood urea nitrogen(BUN)

malondialdehyde (MDA)

superoxide dismutase (SOD) were measured by different methods. Result: QJDH was able to obviously ameliorate the general state of diabetic rats

reduce 24 h urine protein

SCr and BUN content

decrease MDA content and increase SOD activity in kindey tissue. Conclusion: QJDH can relieve the oxidative stress of kindey tissue

and lighten kindey injury induced by diabetes mellitus in diabetic rats.

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Related Author

LI Jin

HUANG Xue-kuan

REN Ling-yan

SHEN Qing

LI Jin1

HUANG Xue-kuan1

REN Ling-yan2

SHEN Qing1

Related Institution

College of Traditional Chinese Medicine,Chongqing Medical University

College of Chemistry and Chemical Engineering,Chongqing University of Science and Technology

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine

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