Effect of 'JUN-SHI’ Herbal Compatibility'’ on Fever Syndrome Model Induced by 2,4- Dinitrophenol Based on Metabonomics

HE Wei; JING Lei; LIU Shu-min; LIU Dong-min; HUANG Zhi-huan; ZU Jin-xiang

doi:CNKI:11-3495/R.20110823.1116.002

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Effect of 'JUN-SHI’ Herbal Compatibility'’ on Fever Syndrome Model Induced by 2,4- Dinitrophenol Based on Metabonomics

更新时间：2024-01-04

- Effect of 'JUN-SHI’ Herbal Compatibility'’ on Fever Syndrome Model Induced by 2,4- Dinitrophenol Based on Metabonomics
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 20, Pages: 173-178(2011)
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- DOI：CNKI:11-3495/R.20110823.1116.002
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- Published：2011
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HE Wei, JING Lei, LIU Shu-min, et al. Effect of 'JUN-SHI’ Herbal Compatibility'’ on Fever Syndrome Model Induced by 2,4- Dinitrophenol Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 173-178.
DOI：

HE Wei, JING Lei, LIU Shu-min, et al. Effect of 'JUN-SHI’ Herbal Compatibility'’ on Fever Syndrome Model Induced by 2,4- Dinitrophenol Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 173-178. DOI： CNKI:11-3495/R.20110823.1116.002.

摘要

目的: 基于代谢组学理论

探讨黄连-栀子药对干预2

4-二硝基苯酚致热病证候模型中生物标记物的变化规律。方法: 运用UPLC-MS技术手段

利用主成分分析(PCA)和偏最小二乘-判别分析法(PLS-DA)数据解析方法

确定黄连-栀子药对对2

4-二硝基苯酚致热病证候模型大鼠尿液中生物标记物的影响。结果: 初步确定2

4-二硝基苯酚致热病证候模型97个生物标志物

其中药对对31个生物标记物具有明显干预作用。结论: 应用代谢组学方法

初步说明黄连-栀子药对对热病证候具有治疗作用。

Abstract

Objective: To explore the the effect of 'Coptis chinensis Gardenia jasminoides’ on the fever syndrome model induced by 2

4-dinitrophenol based on metabonomics. Method: The metabolites in rats urine of 2

4-dinitrophenol-induced fever syndrome model were determined by UPLC-MS and then analyzed by Principle Component Analysis(PCA) and Partial Least Squares discrimination analysis(PLS-DA). Result: Ninty-seven biomarkers on the fever syndrome model induced by 2

4-dinitrophenol were found

and the herbal compatibility have effect on 31 biomarkers of them. Conclusion: The result indicated that the effect on fever syndrome model induced by 2

4-dinitrophenol is related to metabonomics.

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