WANG Jian-hui, LI Lei, LIU Fang, et al. Influence of Tanyu Tongzhi Formula on Stability of Atherosclerotic Vulnerable Plaque of Carotid Artery in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 136-139.
DOI:
WANG Jian-hui, LI Lei, LIU Fang, et al. Influence of Tanyu Tongzhi Formula on Stability of Atherosclerotic Vulnerable Plaque of Carotid Artery in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 136-139. DOI: CNKI:11-3495/R.20110823.1119.016.
Influence of Tanyu Tongzhi Formula on Stability of Atherosclerotic Vulnerable Plaque of Carotid Artery in Rats
Objective: To observe the effects of Tanyu Tongzhi(TYTZ) formula on stability of vulnerable atherosclerotic plaque of carotid artery in rats. Method: With high cholesterol lipid and 2% L-methionine feeding for four weeks
the vulnerable atherosclerotic plaque model was reproduced by operation on carotid artery endothelium for inducing sacculus pull injury. Rats were randomized into five groups: normol control group
model group
simvastatin group
vitamin complex group
TYTZ group (7.8
3.9
1.95 g·kg-1) and administrated orally for 8 weeks. At the end
the blood sample was collected to measure the concentration of Hcy
MMP-9 and TIMP-1
the protein contents of MMP-2 and TIMP-2 in plaque were detected by immunohistochemistry. Result: In contrast to model group
TYTZ (7.8
3.9 g·kg-1)
simvastatin and vitamin complex decreased the concentration of serum MMP-9 and increased the concentration of TIMP-1
the expression of MMP-9 detected in plaque was also lower. Conclusion: TYTZ formula could stablize the vulnerable atherosclerotic plaque of carotid artery through mediating MMP-9 and TIMP-1.
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Related Institution
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