Objective: To investigate local therapeutic effects of Xiongzhi Tongyu San (XZTYS) in transdermal. Method: ① Animals were used and divided into 5 groups including model group

positive control group and treatment groups of large

middle and small dosage. XZTYS was given to rear legs of rats in transdermal daily for 3 days. Thereafter

rat paw edema was caused by inflammation action of carrageenan then extent of paw edema was measured. ② XZTYS were pasted to the back in transdermal daily for 7 days

and inflammatory model was induced by hypodermic injection of air and croton oil. Extravasation and granuloma within the cyst was measured. ③XZTYS was pasted on the ear of mice twice per day. Croton oil was used to establish inflammatory model. Weight of the ear was weighed after 4 hours. ④ XZTYS was pasted on the rear legs of rats daily for 3 days

threshold of pain was measured. ⑤ XZTYS was pasted on abdomen of the mice

the model of analgesia was established by the method of somatic wrenching

and threshold of pain was measured. ⑥ Sixty mice were used and divided into 6 groups including model group

two positive control groups and treatment groups of large

middle and small dosage. XZTYS was pasted on abdomen daily for 3 days. Dextran was iv used to cause model of micro circulation obstruction. The blood circulation of mesentery vessels was observed under dissection microscope. Result: XZTYS at the various doses could markedly suppress swelling of the rat paw and middle dose group extend threshold of pain. large dose group reduce swollen rate of the mice ear and enhance threshold of pain compared to model group. In addition

the middle or large dose group could improve obstruction of micro circulation of mesentery vessels. Conclusion: XZTYScan suppress reaction of acute inflammation and enhance threshold of pain in the rat and mouse models

and improve obstruction of micro circulation of mesentery vessels.