Objective: To study the effect of Simo decoction on leptin and motilin(MTL) in serum of mice with chronic stress

and to explore the mechanism of Simo decoction on Functional dyspepsia(FD). Method: Fourty mice were randomized into normal group

model group

motilium group and Simo decoction group. The mice models were established by exerting the factors of irregular diet

reverse of day and night

binding and stimulating tails

then treated with distilled water

motilium and Simo decoction

respectively. The appetite and body weight of mice wereobserved. The contents of leptin and MTL were detected by enzyme-linked immunosorbent assay(ELISA). Result: The appetite and body weight of model group were lower than normal group(P<0.05)

and the contents of leptin was increase and MTL deacreased in serum compared with the normal group(P<0.05).Simo decoction group and motilium group increased the appetite

body weight and MTL with decreased leptin compared with the model group (P<0.05). Simo decoction group had not statistically significant action compared with Motilium group. Conclusion: The therapeutic mechanism of Simo decoction for FD may probably lie in adjusting the secretion of leptin and MTL in serum.