Objective: To Explore the relationship between pathogenesis of Tourette syndrome(TS) and dominant with presynaptic dopamine nerve fibers. At the same time to observe the effect of Jing’an oral liquid on distribution of dopamine transporter of TS model rats. Method: The model of TS was established by peritoneal injection of 1-(2

5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) 1 mg·g-1 for 21 days. SD rats were randomly divided into 4 groups

the control group

the model group

Jing’an oral liquid group(11 g·kg-1) and tiapride group(0.025 g·kg-1)

and drugs were orally administered for 21 days. In each group with 99 Tc-TRODAT-1 as a ligand

the distribution of dopamine transporter in rat brain was measured by γ-radiation immunity Counter. Result: In model group

three sites’ (striatum

cerebral cortex and hippocampus) radioactive uptake ratio (CMP / GB) was significantly higher than that in control group (P<0.05).In Jing’an oral liquid group three sites’ radioactive uptake ratio (CMP/GB ) was lower than that in model group (P<0.05) with a statistically significant difference. Conclusion: Compared with normal group

the distribution of dopamine transporter(DAT) in model group brain significantly is increased

which may cause the dopamine hyperfunction and lead to TS

.Jing’an oral liquid may be play a therapeutic role by reducing the distribution of DAT

thereby reducing the presynaptic dopamine neurons over-dominance.