Progress on Chemical and Pharmacological Studies of

YU Shao-shuai; CHEN Ming-cang; LI Zhi-xiong; JI Yu-bin; WU-Bin

doi:CNKI:11-3495/R.20110906.1109.009

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Progress on Chemical and Pharmacological Studies of

更新时间：2024-01-04

- Progress on Chemical and Pharmacological Studies of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 21, Pages: 279-283(2011)
- 作者机构：
- 作者简介：
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- DOI：CNKI:11-3495/R.20110906.1109.009
  CLC：
- Published：2011
- 稿件说明：
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YU Shao-shuai, CHEN Ming-cang, LI Zhi-xiong, et al. Progress on Chemical and Pharmacological Studies of [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 279-283.
DOI：

YU Shao-shuai, CHEN Ming-cang, LI Zhi-xiong, et al. Progress on Chemical and Pharmacological Studies of [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(21): 279-283. DOI： CNKI:11-3495/R.20110906.1109.009.

摘要

目的: 对萝蘑科牛奶菜属植物通关藤的化学成分及其药理作用研究的内容进行文献整理和分析。方法: 通过中国科学院上海药物研究所图书数据库平台查阅近5年国内外有关通关藤、通光藤、乌骨藤的药理作用与化学成分的报道。结果: 通关藤的化学成分较为复杂

研究主要集中在C21甾体苷上

药理活性的研究主要集中在抗肿瘤的作用上

现在临床上已有多种以通关藤为主要原料的制剂用于各种癌症的治疗

但是缺少其具体起效的成分研究及其作用机制的研究

因此

对其化学成分及药效学基础的研究必不可少。结论: 近年来对通关藤抗肿瘤的作用研究较多

还需加强对通关藤其他方面的药理作用的研究

特别是其古医书记载对呼吸系统的作用

有必要进行进一步研究。

Abstract

Objective: The chemical compositions and pharmacological activities of the Marsdenia tenacissima were reviewed and analyzied. Method: We search data on chemical compositions and pharmacological effects of M. tenacissima in recent years by the CAS Shanghai institute of materia database platform. Result: The chemical constituents of M. tenacissima is more complex

so the current research focuses on C21 steroidal glycosides. Its pharmacological research is now mainly in their antitumor effect.Now it has a variety of clinical drug which used M. tenacissima as main raw material for treatment of various cancers.But it still lack study which is the specific effective constituents of M. tenacissima and what is the mechanism

therefore

the chemical components and pharmacodynamics of M. tenacissima must be study. Conclusion: In recent years

study on anti-tumor effect of M.tenacissima has more reports

other pharmacological research

particularly the actions on the respiratory system

need to be strengthened

and this paper can provide reference for further research and development.

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Related Institution

Pharmacy College,Chengdu University of Traditional Chinese Medicine

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State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources

Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research,Nanjing University of Chinese Medicine

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