Effect and Mechanism on Anti-inflammatory and Antipyretic of Ethanol Extracts from

CHANG Chu-rui; WU Jian-wei; GUO Guo; FU Ping; JIANG Peng; WU Yun; AN Zheng-fen

doi:CNKI:11-3495/R.20110920.1431.008

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Effect and Mechanism on Anti-inflammatory and Antipyretic of Ethanol Extracts from

更新时间：2024-01-04

- Effect and Mechanism on Anti-inflammatory and Antipyretic of Ethanol Extracts from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 149-151(2011)
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- DOI：CNKI:11-3495/R.20110920.1431.008
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- Published：2011
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CHANG Chu-rui, WU Jian-wei, GUO Guo, et al. Effect and Mechanism on Anti-inflammatory and Antipyretic of Ethanol Extracts from[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 149-151.
DOI：

CHANG Chu-rui, WU Jian-wei, GUO Guo, et al. Effect and Mechanism on Anti-inflammatory and Antipyretic of Ethanol Extracts from[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 149-151. DOI： CNKI:11-3495/R.20110920.1431.008.

摘要

目的: 研究家蝇幼虫乙醇提取物(MDE)对酵母致炎发热大鼠的解热作用及机制。方法: 利用干酵母致炎大鼠发热动物模型

设立生理盐水组:ig等体积生理盐水;模型组:ig等体积生理盐水+大鼠背部sc 15%干酵母20 mL·kg-1;阿司匹林组:ig阿司匹林0.3 g·kg-1;给药组:分别ig MDE(1

0.5

0.25 g·kg-1)

预防性连续给药7 d(n=10)

观察MDE对发热大鼠直肠温度的影响

测定给药后不同时间的体温变化

并采用放免法测定下丘脑中前列腺素E2(PGE2)和环磷腺苷(cAMP)含量。结果: 1

0.5

0.25 g·kg-1MDE具有不同程度的退热作用;并能减少致热大鼠下丘脑中PGE2及cAMP的含量

高剂量组(126.86±24.89) ng·g-1

(9.72±1.11)nmol·g-1;中剂量组(180.12±34.58) ng·g-1

(10.05±0.26)nmol·g-1;低剂量组(203.54±30.46) ng·g-1

(10.79±0.57)nmol·g-1;与模型组(253.70±43.96 )ng·g-1

(12.15±3.11)nmol·g-1比较具有显著性差异(P<0.01

P<0.05)。结论: MDE具有解热作用

其作用机制与降低下丘脑中PGE2以及cAMP有关。

Abstract

Objective :To study the anti-inflammatory and antipyretic effect and mechanism of the ethanol extracts from Musca domestica larvae(MDE) on febrile rats. Method :The rats fever model were made by dry yeast. Saline group was given equal volumes saline (ig); Model group was given equal volumes saline (ig)+ sc 15% dry yeast 20 mL·kg-1 of subcutaneous injection; Treatment group: MDE(1

0.5

0.25 g·kg-1)

ig qd for 7 d

Rectum temperature (ΔT/ ℃)was measured and hypothalamus proataglandin E2(PGE2) and adenosine cyclophosphate(cAMP) were detected by RIA. Result :1

0.5

0.25 g·kg-1MDE had antipyretic effect on febrile rats and could reduce the content of PGE2 and cAMP·kg-1) (126.86±24.89) ng·g-1

(9.72±1.11) nmol·g-1]

·kg-1) (180.12±34.58) ng·g-1

(10.05±0.26) nmol·g-1]

·kg-1)(203.54±30.46) ng·g-1

(10.79±0.57) nmol·g-1]

campared to the control(253.70±43.96) ng·g-1

( 12.15±3.11) nmol·g-1)(P<0.01

P<0.05). Conclusion :The results indicate that ethanol extracts from M. domestica larvae has anti-inflammatory and antipyretic effect

the mechanism may be related to reducing PGE2 and cAMP.

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