Effect of Compatibility of Astragali Radix Effective Parts on Granulocytopoiesis in Myelosuppression Mice

ZHANG Hong-mei; FAN Ying; LIN Shu-ru

doi:CNKI:11-3495/R.20110920.1432.014

您当前的位置：

首页 >

文章列表页 >

Effect of Compatibility of Astragali Radix Effective Parts on Granulocytopoiesis in Myelosuppression Mice

更新时间：2024-01-04

- Effect of Compatibility of Astragali Radix Effective Parts on Granulocytopoiesis in Myelosuppression Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 134-137(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：CNKI:11-3495/R.20110920.1432.014
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
ZHANG Hong-mei, FAN Ying, LIN Shu-ru. Effect of Compatibility of Astragali Radix Effective Parts on Granulocytopoiesis in Myelosuppression Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 134-137.
DOI：

ZHANG Hong-mei, FAN Ying, LIN Shu-ru. Effect of Compatibility of Astragali Radix Effective Parts on Granulocytopoiesis in Myelosuppression Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 134-137. DOI： CNKI:11-3495/R.20110920.1432.014.

摘要

目的: 考察黄芪不同有效部位配伍对骨髓抑制模型小鼠粒细胞-巨噬细胞集落刺激因子(GM-CSF)、粒细胞集落刺激因子(G-CSF)、肿瘤坏死因子-β(TNF-β)的影响。方法: BALB/c小鼠实验第1

5天ip环磷酰胺100 mg·kg-1复制骨髓抑制模型。分为正常组、模型组、黄芪饮片组、酮苷组、糖苷组、糖酮组、糖苷酮组。造模当日给药

正常组、模型组按10 mL·kg-1 ig蒸馏水;黄芪饮片组按10 g·kg-1 ig黄芪水煎液;各有效部位配伍组按黄芪生药量10 g·kg-1分别ig相应治疗药物(酮苷组0.227 g·kg-1

糖苷组0.610 g·kg-1

糖酮组0.514 g·kg-1

糖苷酮组0.678 g·kg-1)。连续ig 15 d。ELISA法检测小鼠骨髓细胞GM-CSF

G-CSF

TNF-β含量。结果: 糖苷组、糖酮组GM-CSF含量明显增加(P<0.05);糖苷组、糖酮组G-CSF含量明显增加

且优于黄芪饮片组(P<0.05);黄芪不同有效部位配伍组TNF-β含量均明显减少

且糖苷组减少TNF-β含量优于酮苷组、糖酮组、糖苷酮组(P<0.05)。结论: 黄芪有效部位可能通过调控细胞因子调控粒系造血;黄芪多糖与皂苷、黄酮配伍后促进粒系造血效果较优。

Abstract

Objective: To sduty the effect of compatibility of Astragali Radix effective parts on granulocyte-macrophage colony-stimulating factor(GM-CSF)

granulocyte colony-stimulating factor (G-CSF)

tumor necrosis factor-β(TNF-β) in myelosuppression mice. Method: BALB/c mice were given cyclophosphamide intraperitoneally at 100 mg·kg-1 on the first

third

fifth day of the experiment to built myelosuppression mice model. The mice were divided into uninfluenced group

model group

Astragali Radix group

ketoside group

glucoside group

saccharon group

glucoside and ketone group. At the same time mice in uninfluenced group and model group were given water ig with the dosage of 10 mL·kg-1. Mice in Astragali Radix group were given the decoction ig with the dosage of 10 mL·kg-1. Mice in groups of compatibility of Astragali Radix effective parts were given corresponding medicine (ig) with the dosage of Astragali Radix 10 g·kg-1 for 15 days: ketoside group 0.227 g·kg-1

glucoside group 0.610 g·kg-1

saccharon group0.514 g·kg-1

glucoside and ketone 0.678 g·kg-1 . Detected GM-CSF

G-CSF

TNF-β

levels in bone marrow cells with ELISA. Result: GM-CSF in glucoside group

saccharon group increased significantly(P<0.05). G-CSF in glucoside group

saccharon group increased significantly and were higher than Astragali Radix group(P<0.05). TNF-β in Groups of compatibility of Astragali Radix decreased significantly and glucoside group was lower than ketoside group

saccharon group

glucoside and ketone(P<0.05). Conclusion: Compatibility of Astragali Radix effective parts may regulate granulocytopoiesis through the regulation of cell factors. Astragali Radix polysaccharides with Astragali Radix flavone or astragaloside accelerated granulocytopoiesis significantly.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Compatibility of Astragali Radix and Salviae Miltiorrhizae Radix et Rhizoma Extract on Pathological Changes of Myocardium in Rats after Myocardial Infarction

"Compatibility" Relationship of Active Components and Heat-clearing and Blood-cooling Effect of Rehmannia glutinosa Roots

Effects of Compatibility of Ephedrae Herba，Asari Radix et Rhizoma， and Aconiti Lateralis Radix Praeparata on ILC2s-Related Factors in Lung of Allergic Rhinitis Model Mice

Renshen Yangrongtang Alleviating Myelosuppression by Reducing Neutrophil Extracellular Traps Through Regulating ROS/MPO

Compatibility Mechanism of Shangerhuang Wan in Enhancing Intestinal Motility in Rat Model of Functional Constipation by Regulating Bile Acid Metabolism

Related Author

YANG Lei

MAO Bing-yu

XU Guo-chang

YE Song-shan

BIAN Hua

ZEN Xiao-tao

CHEN Yaman

CUI Jinpeng

Related Institution

Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine， Henan University of Chinese Medicine

College of Agronomy， Henan Agricultural University

Beijing University of Chinese Medicine

Sichuan Provincial People's Hospital， University of Electronic Science and Technology of China

The Second Affiliated Hospital， Army Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰