Effect and Mechanism of  Saponin on Leydig Cells

ZHENG Juan; ZHAO Ying; WANG Li-fan; HU Hua-gang; XU Si-fan

doi:CNKI:11-3495/R.20110920.1432.015

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Effect and Mechanism of Saponin on Leydig Cells

更新时间：2024-01-04

- Effect and Mechanism of Saponin on Leydig Cells
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 145-148(2011)
- 作者机构：
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- DOI：CNKI:11-3495/R.20110920.1432.015
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- Published：2011
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ZHENG Juan, ZHAO Ying, WANG Li-fan, et al. Effect and Mechanism of Saponin on Leydig Cells[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 145-148.
DOI：

ZHENG Juan, ZHAO Ying, WANG Li-fan, et al. Effect and Mechanism of Saponin on Leydig Cells[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 145-148. DOI： CNKI:11-3495/R.20110920.1432.015.

摘要

目的: 本研究以藏党参的正品长花党参Codonpsis thalictrifolia Wall.为研究对象

对藏党参皂苷对睾丸间质细胞功能的影响进行了初步研究。方法: 利用不同质量浓度的藏党参皂苷对大鼠睾丸间质细胞进行体外培养

并测定细胞分泌睾酮的含量

cAMP的含量以及MTT吸光度。结果: 藏党参皂苷质量浓度为0.4 g·L-1时

可以显著升高体外培养的大鼠睾丸间质细胞分泌睾酮的含量(P<0.05)

提高cAMP的含量(P<0.01)

并降低MTT吸光度(P<0.01)。结论: 藏党参总皂苷可使单个睾丸间质细胞的分泌能力增强

可能由PKA通路介导。

Abstract

Objective: To study effects of Codonpsis thalictrifolia on leydig cells. Method: Leydig cells were collected and cultured in vitro with different concentration of saponin to test quantity of testerone and cAMP and MTT absorbance. Result: When saponin concentration was 0.4 g·L-1

quantity of testerone was significantly increased(P<0.05)

content of cAMP was significantly increased(P<0.01)

and MTT absorbance was significantly reduced(P<0.01). Conclusion: The saponin of C. thalictrifolia can strengthen the capability of single leydig cell to secrete testerone

which is perhaps induced by the pathway of PKA.

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