Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity

GAO Shuang-rong; LIANG Ai-hua; YI Yan; LIU Ting; CAO Chun-yu; WANG Hai-lin; LI Chun-ying; HAO Ran; HUI Lian-qiang

doi:CNKI:11-3495/R.20111017.0940.003

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Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity

更新时间：2024-01-04

- Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 243-247(2011)
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- DOI：CNKI:11-3495/R.20111017.0940.003
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- Published：2011
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GAO Shuang-rong, LIANG Ai-hua, YI Yan, et al. Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 243-247.
DOI：

GAO Shuang-rong, LIANG Ai-hua, YI Yan, et al. Advances in Research on Different Forms of Arsenic in Realgar and its Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 243-247. DOI： CNKI:11-3495/R.20111017.0940.003.

摘要

对雄黄中不同形态砷的毒性及其毒性机制进行文献整理和分析。查阅了国内外有关文献28篇

进行归纳整理并分析汇总。首先介绍了其对肝、肾、膀胱、神经、皮肤、胎儿发育等的毒性损伤情况及损伤机制

砷在生物体内以无机砷和有机砷等不同形态存在

依形态不同毒性有较大差异:三价砷(AsⅢ)可引起肝细胞的凋亡和灶状坏死

五价砷(AsⅤ)

五价甲基砷酸(MMAⅤ)

五价二甲基砷酸(DMAⅤ)可引起肝细胞肿胀和灶状炎症。DMAⅤ的毒性较MMAⅤ大

若长期接触DMAⅤ和MMAⅤ可引起动物膀胱和皮肤组织肿瘤。MMAⅤ和DMAⅤ对调节神经丝蛋白基因的毒性较亚砷酸盐(iAsⅢ)和砷酸盐(iAsⅤ)强

能明显改变细胞骨架基因的表达水平。此外

iAsⅢ和MMAⅢ对人造血干细胞也能产生明显的毒性。这些总结将为系统探究雄黄不同形态砷与毒性的相关性提供基础。

Abstract

The literatures on toxicity and mechanism of different forms of arsenic in realgar were collected and analyzed. Twenty-eight papers in journals home and abroad were consulted and classified. This paper introduces the toxicity and mechanisms of different forms of arsenic in realgar on the liver

kidneys

bladder

nerves

skin

fetal development and etc. The in vivo toxicity of different arsenic compounds is quite different depending on the exiting forms

inorganic arsenic and organic arsenic. AsⅢ can cause liver cells apoptosis and focal necrosis

AsⅤ

MMAⅤ and DMAⅤ can cause liver cells swelling and spotty inflammation. DMAⅤ is more toxic than MMAⅤ. When prolonged exposure to DMAⅤ and MMAⅤ presents

bladder cancer and skin cancer in animals can caused. MMAⅤ and DMAⅤ metabolites are more toxic than iAsⅢ and iAsV to the genes regulating the neurofilament proteins. In addition

iAsⅢ and MMAⅢ can produce significant toxicity to human hematopoietic stem cells. These reports will provide basis for exploring the relations of different forms of arsenic with toxicity.

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