Effects of Aucklandiae Radix,Bran-roasted Products and the Two Active Monomer on Gastrointestinal Motility in Mice

HOU Ying; ZHANG Xu; YIN Li-bo; JIA Tian-zhu

doi:CNKI:11-3495/R.20111017.0940.004

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Effects of Aucklandiae Radix,Bran-roasted Products and the Two Active Monomer on Gastrointestinal Motility in Mice

更新时间：2024-01-04

- Effects of Aucklandiae Radix,Bran-roasted Products and the Two Active Monomer on Gastrointestinal Motility in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 24, Pages: 132-135(2011)
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- DOI：CNKI:11-3495/R.20111017.0940.004
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- Published：2011
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HOU Ying, ZHANG Xu, YIN Li-bo, et al. Effects of Aucklandiae Radix,Bran-roasted Products and the Two Active Monomer on Gastrointestinal Motility in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 132-135.
DOI：

HOU Ying, ZHANG Xu, YIN Li-bo, et al. Effects of Aucklandiae Radix,Bran-roasted Products and the Two Active Monomer on Gastrointestinal Motility in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24): 132-135. DOI： CNKI:11-3495/R.20111017.0940.004.

摘要

目的 :研究木香生品、麸煨品及2个活性单体对正常小鼠和脾虚小鼠胃肠运动的影响。方法 :正常小鼠分为空白组、莫沙比利组、健胃消食片组、木香生品和麸煨品组(5

20 g·kg-1 )

空白组ig蒸馏水

其余各组ig相应药液

连续2周;利血平脾虚小鼠分为空白组、模型组、莫沙必利组、木香生品和麸煨品组(5

20 g·kg-1 )、木香烃内酯组(1.25

2.5

5.0 mg·kg-1)和去氢木香内酯组(2.5

5.0

10.0 mg·kg-1)

正常空白对照组sc 0.15 mg·kg-1生理盐水外

其他各组均sc 0.15 mg·kg-1利血平注射液

空白组和模型组同时ig生理盐水20 mL·kg-1

莫沙比利组

木香生品和麸煨品各剂量组ig药液20 mL·kg-1

木香烃内酯和去氢木香内酯各剂量组ip药液5 mL·kg-1

连续2周。测定小肠炭末推进率和炭末胃内残留率。结果: 木香麸煨品(5

10 g·kg-1)、木香烃内酯和去氢木香内酯可明显促进脾虚小鼠胃排空

木香生品、木香烃内酯(5 mg·kg-1)对脾虚小鼠小肠推进有明显促进作用(P<0.05)。结论: 木香生用理气作用强

治疗脾虚症状效果良好

其活性单体木香烃内酯发挥了较强作用。

Abstract

Objective :To investigate the effects of Aucklandia lappa

bran-roasted products and the two active monomer on gastrointestinal motility in mice. Method : The normal mice were randomly divided into nine groups in average: blank control group

mosapride control group

Jianwei Xiaoshi pian control group

the raw and bran-roasted A.lappa group (5

20 g·kg-1 ).The blank control group was given distilled water and the other groups were given appropriate extracts by intragastic admistration once a day for two weeks. The mice with reserpine induced were divided into fifteen groups:blank control group

model control group

Mosapride control group

the raw and bran-roasted A.lappa group (5

20 g·kg-1 )

costunolide group (1.25

2.5

5.0 mg·kg-1)and dehydrocostuslactone group (2.5

5.0

10.0 mg·kg-1). The blank control group were injected distilled water subcutaneously

the other groups were given reserpine by subcutaneous injection. The blank and model control groups were given distilled water. mosapride control group

the raw and bran-roasted A. lappa group (5

20 g·kg-1 )were given appropriate extracts by intragastic admistration (20 mL·kg-1)

costunolide and dehydrocostuslactone groups were injected(5 mL·kg-1) intraperitoneally for two weeks. Charcoal as a marker was orally administered to determine the propulsive function of small intestine and gastric emptying. Result : The results of gastric emptying and intestine propulsion experiments in normal mice suggested that the effects of the raw and bran-roasted A. lappa on gastric emptying is not significance. The raw materials (10

20 g·kg-1 ) promoted the intestine propulsion(P<0.05). The bran-roasted products(5

10 g·kg-1)

costunolide and dehydrocostuslactone had significance effects on gastric emptying for the reserpine treated mice

the raw materials and costunolide(5 mg·kg-1)promoted the intestine propulsion for the reserpine treated mice(P<0.05). Conclusion : The raw A. lappa has effective in the promoting the circulation of qiand is benefit for spleen deficiency

the active conponent costunolide plays an important role especially.

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