The Effect of Composition of Invigorating Qi and Promoting Blood on Hemorrhagic Blood Deficient Mouse by Qualitative Evenly Design

HUANG Li-ping; CHEN Yao-hui; WU Su-fen; ZHOU Jun; XIONG Yu-jie; LI Sen; YU Ri-yue

doi:CNKI:11-3495/R.20111107.1623.002

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The Effect of Composition of Invigorating Qi and Promoting Blood on Hemorrhagic Blood Deficient Mouse by Qualitative Evenly Design

更新时间：2024-01-04

- The Effect of Composition of Invigorating Qi and Promoting Blood on Hemorrhagic Blood Deficient Mouse by Qualitative Evenly Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 1, Pages: 129-134(2012)
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- DOI：CNKI:11-3495/R.20111107.1623.002
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- Published：2012
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HUANG Li-ping, CHEN Yao-hui, WU Su-fen, et al. The Effect of Composition of Invigorating Qi and Promoting Blood on Hemorrhagic Blood Deficient Mouse by Qualitative Evenly Design[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 129-134.
DOI：

HUANG Li-ping, CHEN Yao-hui, WU Su-fen, et al. The Effect of Composition of Invigorating Qi and Promoting Blood on Hemorrhagic Blood Deficient Mouse by Qualitative Evenly Design[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 129-134. DOI： CNKI:11-3495/R.20111107.1623.002.

摘要

目的: 采用定性均匀设计分析补气生血方剂对失血性血虚模型小鼠的外周血细胞的作用

寻求发挥最佳药效的配伍。方法: 将因素A补气药的12个水平:人参、西洋参、党参、太子参、黄芪、白术、山药、白扁豆、甘草、大枣、刺五加、灵芝与因素B补血药的6个水平:当归、熟地黄、何首乌、白芍、阿胶、龙眼肉

按定性均匀设计U24(242)表组成24个补气生血方剂。小鼠眼眶放血0.5 mL/只

复制失血性血虚模型

测定造模后第1

10 天小鼠外周血细胞值

观察各补气生血方剂对血虚小鼠白细胞计数(WBC)

红细胞计数(RBC)

血红蛋白(HGB)

红细胞比容(HCT)

血小板计数(PLT)的影响

找出反映药效变化最明显的时间点。用主成分分析法分析最明显时间点的WBC

RBC

HGB

HCT

PLT数值及其相互关系

得出主因子。以主因子为指标

建立定性均匀设计中虚拟变量的多元线性回归方程

找出最佳药效配伍。结果: RBC

HGB

HCT变化最明显的时间点为造模后第7 天

反映药效的主因子为RBC

HGB

HCT。以RBC

HGB

HCT第7 天的值为指标

建立了正确的多元线性回归方程

得出最佳药效配伍为人参当归。结论: 对于失血性贫血模型小鼠

人参当归配伍为补气生血方剂中的最佳药效配伍

定性均匀设计法可用于中医方剂配伍研究。

Abstract

Objective : To analysis the effects of invigorating Qi and promoting blood on hemorrhagic blood deficient in mouse by using qualitative analysis of uniform design and to find out the optimum prescription composition. Method: Twelve supplement Qi medicines

such as Ginseng Radix Et Rhizoma

Panacis Quinquefolii Radix Et Rhizoma

Codonopsis Radix

Pseudostellariae Radix

Astragali Radix

Atractylodis Macrocephalae Rhizoma

Dioscoreas Rhizoma

Lablab Semen Album

Glycyrrhiae Radix

Jujube Fructus

Acanthopanacisi Senticosi Radix Et Rhizoma Seu Caulis

Ganoderma

and 6 supplement blood medicines

such as Angelicae Sinensis Radix

Rehmanniae Radix

Polygoni Multiflori Radix

Paeoniae Radix Alba

Asini Corii Colla

Longan Arillus

were composed of 24 supplement Qi and engendering blood prescriptions according to U24(242) qualitative analysis of uniform design. The hemorrhagic blood deficient mouse model was obtained with 0.5 mL orbital bleeding. Peripheral blood cells were counted after 1 d

4 d

7 d

10 d modeling to find the best diversify time of potency. The content of RBC

HGB

HCT

WBC

PLT of the obvious effective time and the relationship between effect with administration time were analyzed using principal component analysis method to find out the major cause. Multiple linear regression with dummy variable was set up to find out the best prescription composition. Result: The best diversify time of potency was on 7 d.RBC

HGB

HCT were the major cause indexes. The multiple linear regression were set up and the composition of Ginseng Radix and Astragali Sinensis Radix appears to be the best compatibility for the efficacy. Conclusion : The composition of Ginseng Radix and Astragali sinensis Radix is the best compatibility for blood loss anemia mouse. Qualitative analysis of uniform design is feasible to be used in the compatibility study.

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Related Institution

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Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique， Ministry of Education，Tianjin University of Traditional Chinese Medicine

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