ZHANG Xian-tao, LIANG Jun, LIU Hong-xia, et al. Protective Effects of Ginkgolide N on Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 141-144.
DOI:
ZHANG Xian-tao, LIANG Jun, LIU Hong-xia, et al. Protective Effects of Ginkgolide N on Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 141-144. DOI: CNKI:11-3495/R.20111107.1627.009.
Protective Effects of Ginkgolide N on Focal Cerebral Ischemia Reperfusion Injury in Rats
Objective: To investigate the protective effect and the mechanism of ginkgolide N (GN) model of focal cerebral ischemia reperfusion injury in rat. Method: The model of ischemia (2 hours) and reperfusion (22 hours) induced by thread approach was reproduced for evaluating the effect of GN on the neurological symptoms
infarction area percentage
rate of brain water
content of malondialdehyde (MDA)
activitiy of SOD in the brain tissues and the intracellular i in the cerebral cortex. Result: Compared with I/R group
GN high dosage group
middle dosage group and nimodipine group relieved signfecantly the neurological symptoms and reduced the cerebral infarction area percentage and content of brain water in rats
meanwhile all GN and nimodiping groups ameliorated the activity of SOD and decreased MDA content and[Ca2+]i level after ischemia and reperfusion injury. Conclusion: GN has the protective effect on rats with cerebral focal ischemia and reperfusion injury
which may be related to that GN can reduce the content of brain water
infarction area percentage
content of MDA and[Ca2+]i level and increase the activity of SOD.
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