Objective: To observe the hematopoietic effects and mechanisms of Bushen Jiedu Huoxue recipe and Yiqi Buxue recipe in the marrow-depressed mice. Method: Eighty Kunming mice were randomly divided into 4 groups: normal control group

model group

Bushen Jiedu Huoxue group(20.55 g ·kg-1 ·d-1)

Yiqi Buxue group (17.47 g ·kg-1 ·d-1). The marrow-depressed model was established by ip cyclophos-phamide (CTX)100 mg ·kg-1 for 3 days. After model establishment

the mice were ig treated with different recipes for 10 days. Peripheral blood cells were counted by microcellcounter; bone marrow nucleated cell and the amount of colony forming unit-granulocyte-macrophage(CFU-GM)

colony forming unit-erythrocyte(CFU-E)and brust forming unit-erythocyte (BFU-E) were counted to study the effects of the proliferation of hematopoietic progenitor cell (HPC)11 days after the successful model set. Result: The Bushen Jiedu Huoxue recipe and Yiqi Buxue recipe could increase the number of WBC

PLT

bone mallow nucleated cell(BMNC)

promote the proliferation of hematopoietic progenitor cell(HPC).The quantities of CFU-GM

CFU-E

BFU-E were significantly higher than the model group(P<0.01). Conclusion: Both of Bushen Jiedu Huoxue and Yiqi Buxue can promote the colony formation of bone marrow hematopoietic progenitor cells

and alleviate the effect of bone marrow suppression after chemotherapy

while the former one was more significant in improving thrombocytopenia

to promote their recovery. Its mechanism may be vary in the bone marrow hematopoietic cell differentiation process or in the micro-environment.