GUO Jian-sheng, LIU Hong-yan, HUANG Xiao-juan, et al. Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 139-143.
DOI:
GUO Jian-sheng, LIU Hong-yan, HUANG Xiao-juan, et al. Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 139-143. DOI: CNKI:11-3495/R.20111116.1422.001.
Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice
Objective: To observe effects and mechanism of the Santali Albi Lignum different extracts on small intestine propulsion and gastric emptying. Method: Mice were randomly divided into control group and groups of extracted parts. The treatment groups take corresponding exreacts with dose of 1.9 g·kg-1
once a day for 3 days. Phenol red emptying method was used
normal
neostigmine and atropine load mice were used for experimental models. Result: Santali Albi Lignum water liquid
ethanol-extraction liquid
naphtha
water liquid ether extract part of the gastric inhibited emptying normal mice (P<0.05)
the stomach and retention rate increased. Santali Albi Lignum water fluid
liquid water extract-alcohol ethanol-extraction
liquid ether extract part inhibited emptying in atropine gastric inhibition models (P<0.05)
the residual rate decreased
and Santali Albi Lignum water decoction inhibited small intestine movement in atropine mice models (P<0.05)
promoting rate increased. The decoction of Santali Albi Lignum
ethanol-extraction liquid
naphtha
ethanol-extraction liquid ethyl acetate extract inhibited gastric emptying in neostigmine induced mice model (P<0.05)。The performance for the retention rate increased
the decoction of Santali Albi Lignum
ethanol-extraction liquid
naphtha
water liquid ether extract parts and ethanol-extraction liquid ether extract parts and ethanol-extraction liquid ethyl acetate extract inhibited small intestine propulsion in model mice induced by neostigmine (P<0.05)
promoting rate reduced. Santali Albi Lignum water liquid part
ethanol-extraction liquid part
naphtha parts and ethanol-extraction liquid petroleum ether parts and ethanol-extraction liquid ether inhibited mice induced gastric emptying in model mice induced by neostigmine (P<0.05)
emptying rate increased. Conclusion: Santali Albi Lignum on small intestine propulsion and gastric emptying have two-wayregulation function
Santali Albi Lignum water fluid
ethanol-extraction liquid in atropine and neostigmine models have significantl inhibition Santali Albi Lignum
and volatile model experiments showed obvious inhibitory effect on intestines convulsion
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Related Author
SHU Zun-peng
YANG Yan-ni
WANG Yi
WANG Qiu-hong
KUANG Hai-xue
Li-rong GUO
Jian-feng XU
Yan-ming ZHANG
Related Institution
General Hospital of Ningxia Medical University
Department of Chinese Traditional Medicine,Guangzhou General Hospital, Guangzhou Military Command
Department of Gastroenterology,Hebei Provincial Hospital of Integrative Chinese and Western Medicine