Objective: To study the effects of Liuwei Dihuang Wan on the animal senile dementia models with Deficiency of the Kidney. Method: Forty eight mice were randomly divided into control group

model group

Liuwei Dihuang Wan group and sailuotong(SLT) group. To establish the senile dementia

the mice of the model group

Liuwei Dihuang Wan group and SLT group were treated by subcutaneous injection of hydrocortisone from first day to 40th days

and then intracerebroventricular injection of amyloid β-protein(25-35) (Aβ25-35) at 20th days

and the mice were given the same volume of normal saline in the control. From 21th day to 40th day

Liuwei Dihuang Wan-treated mice and SLT-treated mice were orally administered with Liuwei Dihuang Wan(8 g·kg-1) and SLT (32 mg·kg-1)

respectively

animals in control group and model group were given an equivalent amount of distilled water. From 31th days

the following changes including body weight

locomotor activity

learning and memory

the fatigue resistance

serum corticosterone

immunological indexes and the histopathology factors of brain were observed. Result: Compared with the control group

the model group showed that weight grew slowly

autonomic activity decreased

the ability of learning and memory impaired

exhaustive running time shortened

thymus index

spleen index and spleen cell stimulation index decreased

the level of serum corticosterone reduced. And after 20 days of administration of Liuwei Dihuang Wan

all such indexes of mice were significantly improved(P<0.05

P<0.01)

while SLT-treated mice showed no significant effects compared with the model group. Conclusion: Liuwei Dihuang Wan can significantly improve senile dementia with deficiency of the kidney

but SLT is not suitable.