中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展

张团庄; 宋渊; 何志军; 刘涛; 吕汐妍; 魏晓涛; 沈稼轩; 梁旭东; 朱克玉; 乔靖

doi:10.13422/j.cnki.syfjx.20230508

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中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展

综述 | 更新时间：2023-10-20

- 中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展
- Chinese Medicine Intervenes in NLRP3 Inflammasome in Treatment of Bone and Joint Diseases： A Review
- 中国实验方剂学杂志 2023年29卷第22期页码：193-203
- 作者机构：
  
  1.甘肃中医药大学，兰州 730000
  2.甘肃省中医院，兰州 730000
- 作者简介：
  
  张团庄，在读硕士，从事中医药防治骨伤科疾病研究，E-mail：1783453709@qq.com
  宋渊，教授，主任医师，研究生导师，从事中医药防治骨伤科疾病研究，E-mail：songyuan3947@126.com
- 基金信息：
  
  国家自然科学基金项目(81860863;81660802);甘肃省卫生行业科研计划项目(GSWSKY-2019-89);甘肃省中医药管理局重点课题(GZKZ-2020-2);甘肃省中医药管理局普通课题(GZKG-2021-51);甘肃省重点研发计划项目(21YF5FA021);甘肃省青年科技基金计划项目(21JR11RA211);兰州市人才创新创业专项(2019-RC-63)
- DOI：10.13422/j.cnki.syfjx.20230508
  中图分类号： R2-0;R22;R285.5;R284;R33
- 纸质出版日期：2023-11-20，
  
  网络出版日期：2023-02-13，
  
  收稿日期：2022-11-19，
- 稿件说明：
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张团庄,宋渊,何志军等.中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展[J].中国实验方剂学杂志,2023,29(22):193-203.

ZHANG Tuanzhuang,SONG Yuan,HE Zhijun,et al.Chinese Medicine Intervenes in NLRP3 Inflammasome in Treatment of Bone and Joint Diseases： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(22):193-203.
张团庄,宋渊,何志军等.中药干预NLRP3炎症小体治疗骨关节相关疾病研究进展[J].中国实验方剂学杂志,2023,29(22):193-203. DOI： 10.13422/j.cnki.syfjx.20230508.

ZHANG Tuanzhuang,SONG Yuan,HE Zhijun,et al.Chinese Medicine Intervenes in NLRP3 Inflammasome in Treatment of Bone and Joint Diseases： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(22):193-203. DOI： 10.13422/j.cnki.syfjx.20230508.

摘要

骨关节疾病患病率正随着我国社会老年人口数量的不断增加正在逐年攀升，常见的骨关节疾病包括骨质疏松、骨性关节炎、痛风性关节炎、类风湿性关节炎、椎间盘退变，其临床表现主要共同点就是不同部位的剧烈疼痛，严重影响患者日常生活。故而如何缓解骨关节疾病疼痛，降低骨关节疾病患病率，提高患者生活质量，是当今医学领域研究的重要课题和热点。研究证实，NOD样受体热蛋白结构域相关蛋白3（NLRP3）炎症小体作为一种模式识别受体，通过参与骨关节疾病炎症反应、软骨细胞增殖、成骨细胞和破骨细胞的分化、椎间盘细胞的炎症与焦亡、细胞外基质降解和凋亡、线粒体功能障碍、内质网应激及活性氧损伤，与骨关节相关疾病的发生发展有着紧密的联系。中医药治疗骨关节相关疾病历史悠久，疗效显著，且占据着重要的治疗地位。同时有研究表明，中医药能够通过抑制NLRP3炎症小体，改善骨关节疾病病理改变，缓解骨关节疾病带来的疼痛，发挥防治骨关节疾病的作用。因此，该文通过查阅了国内外最新研究进展，简单阐述了NLRP3炎症小体与骨关节疾病发生发展的关系，并总结了中药单体、中药提取物及中药复方干预NLRP3炎症小体治疗骨关节疾病的最新研究报道，以期为骨关节疾病发病机制及药物治疗的深入研究提供新思路，为临床上运用中医药防治骨关节疾病提供依据。

Abstract

The prevalence of osteoporosis， osteoarthritis， gouty arthritis， rheumatoid arthritis， and intervertebral disc degeneration is increasing year by year with the growing number of elderly people， and the common clinical manifestations of these diseases include severe pain in different areas， which seriously affects the daily life of the patients. Therefore， how to relieve the pain and reduce the prevalence of bone and joint diseases and improve the quality of life of the patients is a hot spot in the medical field. Studies have confirmed that NOD-like receptor family， pyrin domain-containing protein 3 （NLRP3） inflammasomes， as pattern recognition receptors， are involved in the inflammation， chondrocyte proliferation， osteoblast and osteoclast differentiation， intervertebral disc cell inflammation and scorching， extracellular matrix degradation and apoptosis， mitochondrial dysfunction， endoplasmic reticulum stress， and reactive oxygen species damage， demonstrating close link with the development of bone and joint diseases. Chinese medicine has a long history and demonstrates remarkable therapeutic effects in the treatment of bone and joint diseases. It can mitigate the pathological changes of bone and joint diseases by inhibiting NLRP3 inflammasomes to alleviate the pain， playing a role in preventing and treating these diseases. Therefore， this paper briefly describes the relationship between NLRP3 inflammasomes and the development of bone and joint diseases by reviewing the latest research progress at home and abroad. We summarize the latest studies about the active components， extracts， and compound prescriptions of Chinese medicines in the treatment of bone and joint diseases via regulating NLRP3 inflammasomes. This review is expected to offer new insights into the in-depth research on the pathogenesis and drug treatment of bone and joint diseases and provide a basis for the clinical application of Chinese medicine in the prevention and treatment of such diseases.

关键词

NOD样受体热蛋白结构域相关蛋白3（NLRP3）炎症小体中医药骨质疏松骨性关节炎痛风性关节炎类风湿性关节炎椎间盘退变

Keywords

NOD-like receptor family， pyrin domain-containing protein 3 （NLRP3） inflammasomeChinese medicineosteoporosisosteoarthritisgouty arthritisrheumatoid arthritisintervertebral disc degeneration

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