中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展

阳凌峰; 朱莹; 喻斌; 林瑞芳; 徐寅

doi:10.13422/j.cnki.syfjx.20230901

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中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展

综述 | 更新时间：2023-11-07

- 中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展
- Traditional Chinese Medicine Treats Ulcerative Colitis by Intervening in Mitochondrial Quality Control： A Review
- 中国实验方剂学杂志 2023年29卷第23期页码：245-252
- 作者机构：
  
  1.湖南中医药大学，长沙 410208
  2.湖南中医药大学第一附属医院，长沙 410007
- 作者简介：
  
  阳凌峰，在读硕士，从事中医药防治消化系统疾病，E-mail：yanglingfeng1971@163.com
  徐寅，硕士，副教授，从事中医药防治消化系统疾病，E-mail：673018872@qq.com
- 基金信息：
  
  国家自然科学基金面上项目(81874466);全国名老中医药专家传承工作室建设项目(国中医药人教函（2022）75号)
- DOI：10.13422/j.cnki.syfjx.20230901
  中图分类号： R2-0;R22;R285.5;R284;R33
- 纸质出版日期：2023-12-05，
  
  网络出版日期：2023-04-06，
  
  收稿日期：2022-12-09，
- 稿件说明：
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阳凌峰,朱莹,喻斌等.中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展[J].中国实验方剂学杂志,2023,29(23):245-252.

YANG Lingfeng,ZHU Ying,YU Bin,et al.Traditional Chinese Medicine Treats Ulcerative Colitis by Intervening in Mitochondrial Quality Control： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):245-252.
阳凌峰,朱莹,喻斌等.中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展[J].中国实验方剂学杂志,2023,29(23):245-252. DOI： 10.13422/j.cnki.syfjx.20230901.

YANG Lingfeng,ZHU Ying,YU Bin,et al.Traditional Chinese Medicine Treats Ulcerative Colitis by Intervening in Mitochondrial Quality Control： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):245-252. DOI： 10.13422/j.cnki.syfjx.20230901.

摘要

溃疡性结肠炎是一种累积结直肠黏膜及黏膜下层的慢性炎症性肠病，具有一定的癌变风险，且近年来溃疡性结肠炎的发病率在全球范围内呈上升趋势。然现代医学对其发病机制尚未完全阐明，即使最新药物的缓解率也低于50%，严重影响患者的工作和生活质量。线粒体是真核生物细胞的“发电站”，参与活性氧产生、氧化磷酸化生成三磷酸腺苷等各种重要的生理过程，其功能障碍会导致一系列疾病的发生。线粒体质量控制是维持线粒体形态、数量及质量稳定的重要方式。大量研究表明，以线粒体生物发生水平低下、过度线粒体氧化应激、线粒体自噬缺陷、线粒体动力学紊乱及钙调节异常为特征的线粒体质量控制失调与溃疡性结肠炎的发生发展密切相关。近年来，中医药通过多途径、多通路、多靶点干预线粒体质量控制治疗溃疡性结肠炎己取得一定进展，但目前尚缺乏中医药干预线粒体质量控制治疗溃疡性结肠炎的总结性综述。故该文对中医药领域干预线粒体质量控制治疗溃疡性结肠炎进行总结性梳理，以期为临床中医药治疗溃疡性结肠炎提供一定的思路及借鉴。

Abstract

Ulcerative colitis （UC）， a chronic inflammatory bowel disease with the accumulation of colorectal mucosa and submucosa， has a risk of developing into cancer. In recent years， the incidence of UC has been on the rise worldwide. However， its pathogenesis has not been fully elucidated by modern medicine， and even the remission rate of the latest drugs is lower than 50%， which seriously affects the patients' work and quality of life. Mitochondria， as the "power station" of eukaryotic cells， are involved in a variety of physiological processes such as the production of reactive oxygen species and the production of adenosine triphosphate by oxidative phosphorylation， and their dysfunction can lead to a series of diseases. Mitochondrial quality control （MQC） is an important way to maintain the stability of mitochondrial form， quantity， and quality. Studies have shown that MQC disorders characterized by low mitochondrial biogenesis， excessive mitochondrial oxidative stress， mitochondrial autophagy defects， mitochondrial dynamics disorders， and calcium regulation abnormalities are closely related to the occurrence and development of UC. Although progress has been achieved in the treatment of UC by traditional Chinese medicine （TCM） which can regulated MQC in a multi-pathway and multi-target manner in recent years， a review on the treatment of UC by TCM via the intervention in MQC remains to be carried out. Therefore， this paper summarized the TCM treatment of UC by regulating MQC， aiming to provide new ideas for the clinical treatment of UC by TCM.

关键词

线粒体线粒体质量控制中医药溃疡性结肠炎

Keywords

mitochondrionmitochondrial quality controltraditional Chinese medicineulcerative colitis

references

FEUERSTEIN J D，MOSS A C，FARRAYE F A.Ulcerative colitis［J］.Mayo Clin Proc，2019，94（7）：1357-1373.

PORTER R J，KALLA R，HO G T.Ulcerative colitis：Recent advances in the understanding of disease pathogenesis［J］.F1000Res，2020，9：F1000.

PARK J，CHEON J H.Incidence and prevalence of inflammatory bowel disease across asia［J］.Yonsei Med J，2021，62（2）：99-108.

KOBAYASHI T，SIEGMUND B，LE BERRE C，et al.Ulcerative colitis［J］.Nat Rev Dis Primers，2020，6（1）：74.

张声生，沈洪，郑凯，等.溃疡性结肠炎中医诊疗专家共识意见（2017）［J］.中华中医药杂志，2017，32（8）：3585-3589.

黎秀娟，黎丽群，马超北，等.基于“脾-线粒体相关”探讨NLRP3炎症小体与慢性萎缩性胃炎的关系［J］.中国实验方剂学杂志，2023，29（17）：267-273.

CHOJNACKI A K，NAVANEETHA KRISHNAN S，JIJON H，et al.Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon［J］.Mitochondrion，2023，68：44-59.

HO G T，THEISS A L.Mitochondria and inflammatory bowel diseases：Toward a stratified therapeutic intervention［J］.Annu Rev Physiol，2022，84：435-459.

SUI G Y，WANG F，LEE J，et al.Mitochondrial control in inflammatory gastrointestinal diseases［J］.Int J Mol Sci，2022，23（23）：14890.

PFEUFFER S，MÜNTEFERING T，ROLFES L，et al.Deficiency of the two-pore potassium channel KCNK9 impairs intestinal epithelial cell survival and aggravates dextran sodium sulfate-induced colitis［J］.Cell Mol Gastroenterol Hepatol，2022，14（6）：1199-1211.

TIAN Q，XU Z，SUN Q，et al.Broccoli-derived glucoraphanin activates AMPK/PGC1α/NRF2 pathway and ameliorates dextran-sulphate-sodium-induced colitis in mice［J］.Antioxidants （Basel），2022，11（12）：2404.

ZHANG D，ZHOU X，ZHANG K，et al.Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis［J］.Int J Biol Macromol，2023，235：123803.

GUO W，SUN Y，LIU W，et al.Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer［J］.Autophagy，2014，10（6）：972-985.

DANNE C，MICHAUDEL C，SKERNISKYTE J，et al.CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival［J］.Gut，2022，gutjnl-2022-326917.

MISHRA S R，MAHAPATRA K K，BEHERA B P，et al.Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics［J］.Int J Biochem Cell Biol，2021，136：106013.

FEDOROV A V，CHELOMBITKO M A，CHERNYAVSKIJ D A，et al.Mitochondria-targeted antioxidant SkQ1 prevents the development of experimental colitis in mice and impairment of the barrier function of the intestinal epithelium［J］.Cells，2022，11（21）：3441.

WONG W T，WU C H，LI L H，et al.The leaves of the seasoning plant Litsea cubeba inhibit the NLRP3 inflammasome and ameliorate dextran sulfate sodium-induced colitis in mice［J］.Front Nutr，2022，9：871325.

SOK S P M，ORI D，WADA A，et al.1'-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression［J］.Int Immunol，2021，33（7）：373-386.

HONG F，ZHAO M，XUE L L，et al.The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via inhibition of NLRP3 inflammasome［J］.Phytomedicine，2022，102：154163.

GUO W，LIU W，JIN B，et al.Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation［J］.Int Immunopharmacol，2015，24（2）：232-238.

ZHANG W，WANG W，SHEN C，et al.Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome［J］.Aging （Albany NY），2021，13（19）：23193-23209.

ALMANSA-ORDONEZ A，BELLIDO R，VASSENA R，et al.Oxidative stress in reproduction：A mitochondrial perspective［J］.Biology （Basel），2020，9（9）：269.

PFANNER N，WARSCHEID B，WIEDEMANN N.Mitochondrial proteins：From biogenesis to functional networks［J］.Nat Rev Mol Cell Biol，2019，20（5）：267-284.

EL-GHANNAM M S，SAAD M A，NASSAR N N，et al.Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats［J］.Toxicol Appl Pharmacol，2022，438：115906.

AHMED A，TATIANA G，NEERAJ K，et al.Oxphos drives crypt fissioning required for healing of IBD ulcers［J］.Gastroenterology，2022，162（3S）：S52

BOYAPATI R K，DORWARD D A，TAMBORSKA A，et al.Mitochondrial DNA is a pro-inflammatory damage-associated molecular pattern released during active IBD［J］.Inflamm Bowel Dis，2018，24（10）：2113-2122.

HAN J，LI W，SHI G，et al.Atractylenolide Ⅲ improves mitochondrial function and protects against ulcerative colitis by activating AMPK/SIRT1/PGC-1α［J］.Mediators Inflamm，2022，2022：9129984.

SHAFIK N M，GABER R A，MOHAMED D A，et al.Hesperidin modulates dextran sulfate sodium-induced ulcerative colitis in rats：Targeting sphingosine kinase-1- sphingosine 1 phosphate signaling pathway，mitochondrial biogenesis，inflammation，and apoptosis［J］.J Biochem Mol Toxicol，2019，33（6）：e22312.

SAFWAT EL-DEEB O，EL-ESAWY R O，AL-SHENAWY H A，et al.Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis：The restorative effects of β-glucan and/or celastrol［J］.Redox Rep，2022，27（1）：60-69.

尹珊珊，马红，姜琦，等.安石榴苷通过SIRT1/PGC-1α/NRF1通路对实验性结肠炎小鼠肠黏膜损伤的影响及其机制［J］.免疫学杂志，2022，38（8）：655-664.

ALATTAR A，ALSHAMAN R，AL-GAYYAR M M H.Therapeutic effects of sulforaphane in ulcerative colitis：effect on antioxidant activity，mitochondrial biogenesis and DNA polymerization［J］.Redox Rep，2022，27（1）：128-138.

YANG S，LI F，LU S，et al.Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo［J］.J Ethnopharmacol，2022，283：114739.

WANG D，ZHANG Y，YANG S，et al.A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function［J］.Int J Biol Macromol，2019，125：572-579.

HE W，PAN H，TAO P，et al.Panax notoginseng attenuates hypoxia-induced glycolysis in colonic mucosal epithelial cells in DSS-induced colitis［J］.Ann Transl Med，2022，10（4）：218.

MOUZAOUI S，BANERJEE S，DJERDJOURI B.Low-dose curcumin reduced TNBS-associated mucin depleted foci in mice by scavenging superoxide anion and lipid peroxides，rebalancing matrix NO synthase and aconitase activities，and recoupling mitochondria［J］.Inflammopharmacology，2020，28（4）：949-965.

ZHAO Y，LIU P，ZHANG Y，et al.Demethyleneberberine blocked the maturation of IL-1β in inflammation by inhibiting TLR4-mitochondria signaling［J］.Int Immunopharmacol，2022，113（Pt A）：109319.

ZHENG Y，LIANG C，LI Z，et al.Study on the mechanism of Huangqin decoction on rats with ulcerative colitis of damp-heat type base on mtDNA，TLR4，p-PI3K，p-Akt protein expression and microbiota［J］.J Ethnopharmacol，2022，295：115356.

PALIKARAS K，LIONAKI E，TAVERNARAKIS N.Mechanisms of mitophagy in cellular homeostasis，physiology and pathology［J］.Nat Cell Biol，2018，20（9）：1013-1022.

LIANG H，ZHANG F，WANG W，et al.Heat shock transcription factor 2 promotes mitophagy of intestinal epithelial cells through PARL/PINK1/Parkin pathway in ulcerative colitis［J］.Front Pharmacol，2022，13：893426.

LI P，CHEN G，ZHANG J，et al.Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis［J］.Food Funct，2022，13（5）：2985-2997.

MAI C T，WU M M，WANG C L，et al.Palmatine attenuated dextran Sulfate sodium （DSS）-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation［J］.Mol Immunol，2019，105：76-85.

TAO Y，QIAO S M，LV C J，et al.Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway［J］.Phytother Res，2022，36（8）：3248-3264.

刘宇，付骞卉，史梦妮，等.翻白草调控线粒体自噬途径治疗UC的作用机制研究［J］.中国中药杂志，2021，46（15）：3907-3914.

LIU C，WANG J，YANG Y，et al.Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice［J］.Biochem Pharmacol，2018，155：366-379.

KONG J，XIANG Q，SHI G，et al.Licorice protects against ulcerative colitis via the Nrf2/PINK1-mediated mitochondrial autophagy［J］.Immun Inflamm Dis，2023，11（1）：e757.

YU T，LU X，LIANG Y，et al.Ononin alleviates DSS-induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy［J］.Immun Inflamm Dis，2023，11（2）：e776.

王睿，王键，查安生，等.地马煎剂对溃疡性结肠炎大鼠HIF-1α/BNIP3/Beclin-1通路相关蛋白及线粒体自噬水平的调节作用［J］.中华中医药杂志，2019，34（9）：3956-3959.

苗金雪，马旭冉，冯雪，等.黄芩汤对UC模型大鼠PINK1/Parkin通路的作用研究［J］.中医药学报，2021，49（4）：8-13.

GAO S，HU J.Mitochondrial fusion：The machineries in and out［J］.Trends Cell Biol，2021，31（1）：62-74.

CHAN D C.Mitochondrial dynamics and its involvement in disease［J］.Annu Rev Pathol，2020，15：235-259.

MANCINI N L，GOUDIE L，XU W，et al.Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease［J］.Cell Mol Gastroenterol Hepatol，2020，10（2）：287-307.

WANG S Q，YANG X Y，CUI S X，et al.Heterozygous knockout insulin-like growth factor-1 receptor （IGF-1R） regulates mitochondrial functions and prevents colitis and colorectal cancer［J］.Free Radic Biol Med，2019，134：87-98.

CHEN Y，ZHENG Y，WEN S，et al.Regulation of MFN2 by berberine alleviates obesity exacerbated colitis［J］.Biochem Biophys Res Commun，2020，531（2）：250-255.

QIN Y，YU Y，YANG C，et al.Atractylenolide I inhibits NLRP3 inflammasome activation in colitis-associated colorectal cancer via suppressing Drp1-mediated mitochondrial fission［J］.Front Pharmacol，2021，12：674340.

WU C，YANG H，HAN C，et al.Quyu Shengxin decoction alleviates DSS-induced ulcerative colitis in mice by suppressing RIP1/RIP3/NLRP3 signalling［J］.Evid Based Complement Alternat Med，2021，2021：6682233.

GARBINCIUS J F，ELROD J W.Mitochondrial calcium exchange in physiology and disease［J］.Physiol Rev，2022，102（2）：893-992.

LEE H，JEON J H，LEE Y J，et al.Inhibition of pyruvate dehydrogenase kinase 4 in CD4+ T cells ameliorates intestinal inflammation［J］.Cell Mol Gastroenterol Hepatol，2023，15（2）：439-461.

葛巍，赵海梅，李燕珍，等.四神丸对结肠炎小鼠结肠能量代谢水平调控机制［J］.中华中医药杂志，2022，37（1）：169-173.

常孟然.中医序贯疗法对溃疡性结肠炎大鼠线粒体及能量代谢的影响［D］.北京：北京中医药大学，2016.

SCHNEIDER A M，ÖZSOY M，ZIMMERMANN F A，et al.Expression of oxidative phosphorylation complexes and mitochondrial mass in pediatric and adult inflammatory bowel disease［J］.Oxid Med Cell Longev，2022，2022：9151169.

VERMA A，PITTALA S，ALHOZEEL B，et al.The role of the mitochondrial protein VDAC1 in inflammatory bowel disease：A potential therapeutic target［J］.Mol Ther，2022，30（2）：726-744.

FORMENTINI L，SANTACATTERINA F，NÚÑEZ DE ARENAS C，et al.Mitochondrial ROS production protects the intestine from inflammation through functional M2 macrophage polarization［J］.Cell Rep，2017，19（6）：1202-1213.

HOU Y，SUN X，GHEINANI P T，et al.Epithelial SMYD5 exaggerates IBD by down-regulating mitochondrial functions via post-translational control of PGC-1α stability［J］.Cell Mol Gastroenterol Hepatol，2022，14（2）：375-403.

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