NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展

刘国政; 陈嫣嫣; 杨硕; 刘怡; 赵炎培; 周丽杰; 王鑫宇; 孙阳阳; 李言; 段金江; 陈力铭; 肖景东

doi:10.13422/j.cnki.syfjx.20232191

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NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展

综述 | 更新时间：2023-11-07

- NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展
- Intervention of Traditional Chinese and Western Medicine in NLRP3 Inflammasome-mediated Digestive System Diseases： A Review
- 中国实验方剂学杂志 2023年29卷第23期页码：174-188
- 作者机构：
  
  辽宁中医药大学，沈阳 110847
  2.辽宁中医药大学附属第四医院，沈阳 110847
- 作者简介：
  
  刘国政，在读硕士，从事中西医结合临床研究，E-mail：1127017862@qq.com
  肖景东，博士，教授，从事中医内科学研究，E-mail：xiaojd@126.com
- 基金信息：
  
  国家自然科学基金项目(82074296);辽宁省教育厅科学研究经费项目(L202063)
- DOI：10.13422/j.cnki.syfjx.20232191
  中图分类号： R2-0;R22;R2-031;R714
- 纸质出版日期：2023-12-05，
  
  网络出版日期：2023-04-23，
  
  收稿日期：2022-11-22，
- 稿件说明：
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刘国政,陈嫣嫣,杨硕等.NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展[J].中国实验方剂学杂志,2023,29(23):174-188.

LIU Guozheng,CHEN Yanyan,YANG Shuo,et al.Intervention of Traditional Chinese and Western Medicine in NLRP3 Inflammasome-mediated Digestive System Diseases： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):174-188.
刘国政,陈嫣嫣,杨硕等.NLRP3炎症小体介导的消化系统疾病的中西医干预研究进展[J].中国实验方剂学杂志,2023,29(23):174-188. DOI： 10.13422/j.cnki.syfjx.20232191.

LIU Guozheng,CHEN Yanyan,YANG Shuo,et al.Intervention of Traditional Chinese and Western Medicine in NLRP3 Inflammasome-mediated Digestive System Diseases： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2023,29(23):174-188. DOI： 10.13422/j.cnki.syfjx.20232191.

摘要

核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎症小体作为固有系统的重要组成部分，其异常的激活与多种人类炎症性疾病的发病有关，已有研究证实了其与罹患溃疡性结肠炎、克罗恩病、急性胰腺炎等消化系统疾病之间的相关性，NLRP3炎性小体在消化系统疾病的发生和发展中也发挥了重要的作用。该文基于目前对NLRP3炎症小体活化机制及介导炎症反应的通路的概述，综述NLRP3炎症小体与多种消化系统疾病发病之间的关系及中西医干预治疗的现状。基于NLRP3炎症小体的消化系统疾病，在中医药治疗中效果显著。一些单一的中药或者中药方剂通过激活或抑制NLRP3炎症小体活化，靶向治疗某些消化系统疾病。NLRP3炎症小体可以接受多种内源性和外源性的刺激信号，进而启动和激活并参与介导炎症反应，其自身炎症小体的形成和下游多种炎症因子不仅是介导炎症反应的主要机制，也参与多种消化系统疾病发生发展的机制轴和通路轴，因此可以作为理想的干预治疗某种疾病的识别靶点。未来可以针对多种炎性小体的再发现和深入研究将为多种消化系统疾病的治疗提供新的思路。

Abstract

The aberrant activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 （NLRP3） inflammasome as an essential component of the innate system is implicated in the pathogenesis of several human inflammatory diseases. Studies have confirmed its association with digestive system diseases such as ulcerative colitis， Crohn's disease， and acute pancreatitis， suggesting that the NLRP3 inflammasome plays a role in the initiation and progression of these diseases. Based on the mechanism of NLRP3 inflammasome activation and the pathways that mediate the inflammatory response， this article introduced the relationship between the NLRP3 inflammasome and the pathogenesis of multiple digestive system diseases and the Chinese and western medical therapies. Traditional Chinese medicine （TCM） has demonstrated definite effects on the NLRP3 inflammasome-mediated digestive system diseases. Some single Chinese medicines or TCM prescriptions can treat digestive system diseases by activating or inhibiting NLRP3 inflammasome activation. NLRP3 inflammasome can receive a variety of endogenous and exogenous stimulatory signals， which can initiate， activate， and mediate inflammatory responses. The inflammasome formation and downstream inflammatory cytokines are involved in not only the inflammatory responses but also the development and progression of multiple digestive system diseases. Therefore， the NLRP3 inflammasome can serve as an ideal target for disease treatment. The future rediscovery and in-depth studies of multiple inflammasomes will shed new light on the treatment of multiple digestive system diseases.

关键词

核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎症小体消化系统消化疾病中医药

Keywords

nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 （NLRP3）inflammasomedigestive systemdigestive diseasestraditional Chinese medicine

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