1.中国中医科学院 中医临床基础医学研究所,北京 100700
2.中国中医科学院 中药研究所,北京100700
3.中国中医科学院 中医药信息研究所,北京 100700
4.中国中医科学院 中医基础理论研究所,北京 100700
曹玉清,在读硕士,从事中西医结合防治传染病(疫病)研究,E-mail:cyq2000224@163.com
张华敏,研究员,从事中医理论基础研究,E-mail:hmzhang@icmm.ac.cn
马艳,研究员,从事疫病流行病学及防治,E-mail:mayan0825@sina.com; *
收稿:2024-04-07,
网络出版:2024-05-31,
纸质出版:2024-12-20
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曹玉清,郭旸,尚希钰等.桂枝-泽泻治疗外感疾病中医认识及现代药学研究进展[J].中国实验方剂学杂志,2024,30(24):279-288.
CAO Yuqing,GUO Yang,SHANG Xiyu,et al.Cinnamomi Ramulus-Alismatis Rhizoma in Treatment of External-contraction Diseases from Traditional Chinese Medicine and Modern Pharmacy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(24):279-288.
曹玉清,郭旸,尚希钰等.桂枝-泽泻治疗外感疾病中医认识及现代药学研究进展[J].中国实验方剂学杂志,2024,30(24):279-288. DOI: 10.13422/j.cnki.syfjx.20240739.
CAO Yuqing,GUO Yang,SHANG Xiyu,et al.Cinnamomi Ramulus-Alismatis Rhizoma in Treatment of External-contraction Diseases from Traditional Chinese Medicine and Modern Pharmacy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2024,30(24):279-288. DOI: 10.13422/j.cnki.syfjx.20240739.
桂枝及泽泻是治疗外感疾病的常用中药,桂枝性味辛、甘、温,宣肺散寒,开通腠理,温阳化气,助水液从太阳经而去,具祛湿之功;泽泻甘、寒,渗湿利水,通调水道而泻肺中水饮,且可利小便而除湿热。药对是从历代医家用药经验积累中提炼出来,针对特定病症经过临床应用被证明组成简单且行之有效的配伍。桂枝-泽泻药对是五苓散等古代经典名方的重要组成,二者配伍共奏利水渗湿,温阳化气之功,是治疗外感表证、水湿内停的代表方。通过梳理古代文献发现有数千年散寒除湿作用桂枝-泽泻药对配伍组成的复方方剂数量较多、临床使用广泛。现代药理学研究表明桂枝的有效成分桂皮醛、肉桂酸等,泽泻的有效成分泽泻醇A、23-乙酰泽泻醇B等具有抗炎、抗病毒及免疫调节等作用,且安全性较高,含有该药对配伍的清肺排毒汤在抗击新型冠状病毒感染中发挥了重要作用。尽管关于桂枝、泽泻的各自的相关药学研究较多,然而对该药对研究较少。笔者对桂枝和泽泻治疗外感疾病的中医认识,及二者配伍前后的化学成分、药理作用、毒理学等方面进行系统梳理总结,为进一步研究和拓宽临床应用提供参考。
Cinnamomi Ramulus and Alismatis Rhizoma are commonly used in the treatment of external-contraction diseases. Cinnamomi Ramulus is pungent, sweet, and warm, with the effects of ventilating lung and dispersing cold, warming Yang and transforming Qi, and promoting water and liquid flow from Taiyang meridian to remove dampness. Alismatis Rhizoma is sweet and cold, with the effects of draining dampness and promoting urination, regulating the waterway, removing water retention in lung, and promoting urination to remove dampness and heat. Herbal pairs are extracted from the accumulated experience of medical practitioners over the ages in the use of medicines and have been proved by clinical application to be composed of simple and effective combinations for specific diseases. The herb pair Cinnamomi Ramulus-Alismatis Rhizoma is an important part in ancient classic formulas such as Wulingsan. Both herbs play a role in draining dampness and promoting urination, warming Yang and transforming Qi, being a representative herb pair used for treating external-contraction exterior syndrome and water retention inside. The review of ancient medical publications revealed that there were a large number of compound formulas containing Cinnamomi Ramulus-Alismatis Rhizoma for dispersing cold and removing dampness, which were widely used for thousands of years in clinical practice. Modern pharmacological studies have shown that the active pharmacological components of Cinnamomi Ramulus (cinnamaldehyde and cinnamic acid) and Alismatis Rhizoma (alisol A and 23-acetate alisol B) have anti-inflammatory, antiviral, and immunoregulatory effects and high safety. Qingfei Paidu decoction containing this herbal pair played an important role in fighting against COVID-19. Despite the extensive pharmacological studies on Cinnamomi Ramulus and Alismatis Rhizoma, few studies have been carried out regarding this herb pair. This paper summarizes the traditional Chinese medicine knowledge about Cinnamomi Ramulus and Alismatis Rhizoma in the treatment of external-contraction diseases and summarizes the chemical composition, pharmacological effects, toxicology and other aspects of the two herbs before and after compatibility, aiming to provide a reference for further research and clinical application.
刘德培 . 中华医学百科全书·中医药学,中医内科学 [M]. 北京 : 中国协和医科大学出版社 , 2019 : 58 .
贾振华 , 李红蓉 , 常丽萍 , 等 . 中医学应对疫病的历史回顾与思考 [J]. 中国实验方剂学杂志 , 2020 , 26 ( 11 ): 1 - 7 .
李竹青 , 孙鹏程 , 秦静波 , 等 . 以新型冠状病毒肺炎为例探讨中医体质与外感疾病的关系 [J]. 安徽中医药大学学报 , 2020 , 39 ( 4 ): 1 - 4 .
连建伟 . 《伤寒论》在外感疾病中的运用 [J]. 中华中医药杂志 , 2012 , 27 ( 7 ): 1763 - 1765 .
杨丽娜 , 朱邦贤 . 刘完素外感疾病学术思想研究概况 [J]. 上海中医药杂志 , 2007 , 41 ( 8 ): 77 - 79 .
吴军营 . 《临证指南医案》桂枝运用的研究 [D]. 广州 : 广州中医药大学 , 2011 .
吴普 , 述 , 孙星衍 , 辑 , 石学文 , 点校 . 神农本草经 [M]. 沈阳 : 辽宁科学技术出版社 , 1997 : 15 .
国家药典委员会 . 中华人民共和国药典:一部 [M]. 北京 : 中国医药科技出版社 , 2020 : 239 .
向茜 , 赵文燕 , 王蝉 , 等 . 基于UPLC-Q-TOF-MS的泽泻盐制前后萜类化学成分分析 [J]. 中国实验方剂学杂志 , 2022 , 28 ( 19 ): 154 - 161 .
吴嘉朔 , 常晓燕 , 李壮壮 , 等 . 泽泻汤降脂及抗炎作用分子机制研究进展 [J]. 中国实验方剂学杂志 , 2021 , 27 ( 2 ): 224 - 232 .
TAI Y , ZOU F , ZHANG Q , et al . Quantitative analysis of eight triterpenoids and two sesquiterpenoids in Rhizoma Alismatis by using UPLC-ESI/APCI-MS/MS and its application to optimisation of best harvest time and crude processing temperature [J]. J Anal Methods Chem , 2019 , doi: 10.1155/2019/8320171 http://dx.doi.org/10.1155/2019/8320171 .
XU W , LI X , LIN N , et al . Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography-tandem mass spectrometry [J]. J Pharm Biomed Anal , 2017 , 146 : 314 - 323 .
CHU Y , JIANG H , JU J , et al . A metabolomic study using HPLC-TOF/MS coupled with ingenuity pathway analysis: Intervention effects of Rhizoma Alismatis on spontaneous hypertensive rats [J]. J Pharm Biomed Anal , 2016 , 117 : 446 - 452 .
王艺涵 , 赵佳琛 , 翁倩倩 , 等 . 经典名方中泽泻的本草考证 [J]. 中国实验方剂学杂志 , 2022 , 28 ( 10 ): 229 - 237 .
佚名 . 名医别录 [M]. 北京 : 人民卫生出版社 , 1986 : 25 .
寇宗奭 . 本草衍义 [M]. 北京 : 中国医药科技出版社 , 2018 : 57 .
李时珍 . 本草纲目·上 [M]. 北京 : 人民卫生出版社 , 1957 : 836 .
赵聚峰 , 赵怀舟 . 试论药对的概念及其配伍理论 [J]. 山西中医学院学报 , 2006 , 7 ( 3 ): 16 - 17 .
俞春林 , 杜正彩 , 郝二伟 , 等 . 四类不同功效桂枝药对化学成分与药理作用的研究进展 [J]. 中国实验方剂学杂志 , 2020 , 26 ( 1 ): 226 - 234 .
王兆军 , 张志芳 . 近十年来中药药对研究进展 [J]. 内蒙古中医药 , 2023 , 42 ( 9 ): 151 - 154 .
LU L , LU J , CHEN J , et al . Biomarker identification and pathway analysis of Astragalus membranaceus and Curcuma zedoaria couplet medicines on adenine-induced chronic kidney disease in rats based on metabolomics [J]. Front Pharmacol , 2023 , doi: 10.3389/fphar.2023.1103527 http://dx.doi.org/10.3389/fphar.2023.1103527 .
王玉兰 , 龚李萍 , 郭超峰 . 五苓散实验药理作用及临床应用研究进展 [J]. 湖北中医药大学学报 , 2021 , 23 ( 2 ): 118 - 120 .
马玉杰 , 程引 , 宋长恒 , 等 . 解读太阳病的分类 [J]. 北京中医药大学学报 , 2021 , 44 ( 7 ): 597 - 604 .
邢加兴 , 周雨龙 , 司廷林 . 从津液角度论治《伤寒论》太阳病 [J]. 中国医药导报 , 2022 , 19 ( 6 ): 139 - 142 .
严晓双 , 陆为民 , 郑浩 . 陆为民教授基于“蓄水体质”运用五苓散经验拾萃 [J]. 吉林中医药 , 2024 , 44 ( 2 ): 178 - 181 .
黄宫绣 . 本草求真 [M]. 席与民, 朱肇和, 点校. 北京 : 人民卫生出版社 , 1987 : 83 , 139 .
杨海林 , 李欠 , 邱黛玉 . 基于中药法象理论浅析五苓散的功效及配伍 [J]. 河南中医 , 2021 , 41 ( 2 ): 163 - 165 .
中华人民共和国国务院新闻办公室 . 抗击新冠肺炎疫情的中国行动 [EB/OL].( 2020-06-07 ) [ 2023-11-15 ]. https://www.gov.cn/zhengce/2020-06/07/content_5517737.html https://www.gov.cn/zhengce/2020-06/07/content_5517737.html .
QIAO L , HUANG W , ZHANG X , et al . Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways [J]. Signal Transduct Target Ther , 2021 , 6 ( 1 ): 50 .
FU L , SHAO S , FENG Y , et al . Mechanism of microbial metabolite leupeptin in the treatment of COVID-19 by Traditional Chinese Medicine Herbs [J]. mBio , 2021 , 12 ( 5 ): e0222021 .
XIA K Y , ZHAO Z , SHAH T , et al . Composition, clinical efficiency, and mechanism of NHC-approved "Three Chinese Medicines and Three Chinese Recipes" for COVID-19 treatment [J]. Front Pharmacol , 2021 , doi: 10.3389/fphar.2021.781090 http://dx.doi.org/10.3389/fphar.2021.781090 .
RUCHAWAPOL C , FU W W , XU H X . A review on computational approaches that support the researches on traditional Chinese medicines (TCM) against COVID-19 [J]. Phytomedicine , 2022 , 104 : 154324 .
FU R , LI J , YU H , et al . The Yin and Yang of traditional Chinese and western medicine [J]. Med Res Rev , 2021 , 41 ( 6 ): 3182 - 3200 .
LIU J , ZHANG Q , LI R L , et al . The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus:A review [J]. J Pharm Pharmacol , 2020 , 72 ( 3 ): 319 - 342 .
曹艳梅 , 张囡 , 史楠楠 , 等 . 基于古代经方传承的清肺排毒汤组方配伍分析 [J]. 世界中医药 , 2022 , 17 ( 9 ): 1343 - 1349 .
胡雯婷 , 戴红 . 基于病证结合角度探析新型冠状病毒肺炎的中西医结合诊疗模式 [J]. 中医学报 , 2020 , 35 ( 3 ): 501 - 503 .
The Novel Coronavirus Pneumonia Emergency Response Epidemiology T . The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) -China, 2020 [J]. China CDC Wkly , 2020 , 2 ( 8 ): 113 - 122 .
GUAN W J , NI Z Y , HU Y , et al . Clinical characteristics of coronavirus disease 2019 in China [J]. N Engl J Med , 2020 , 382 ( 18 ): 1708 - 1720 .
CHEN N , ZHOU M , DONG X , et al . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:A descriptive study [J]. Lancet , 2020 , 395 ( 10223 ): 507 - 513 .
国家卫生健康委员会 , 国家中医药管理局 . 关于推荐在中西医结合救治新型冠状病毒感染的肺炎中使用“清肺排毒汤”的通知 [EB/OL].( 2020-02-07 ) [ 2023-11-15 ]. http://www.natcm.gov.cn/yizhengsi/zhengcewenjian/2020-02-07/12876.html http://www.natcm.gov.cn/yizhengsi/zhengcewenjian/2020-02-07/12876.html .
范逸品 , 王燕平 , 马艳 , 等 . 从新型冠状病毒肺炎的寒疫病机探析清肺排毒汤的组方机制 [J]. 中国实验方剂学杂志 , 2020 , 26 ( 16 ): 1 - 5 .
REN W , MA Y , WANG R , et al . Research advance on qingfei paidu decoction in prescription principle, mechanism analysis and clinical application [J]. Front Pharmacol , 2020 , 11 : 589714 .
HUANG K , ZHANG P , ZHANG Z , et al . Traditional Chinese medicine (TCM) in the treatment of COVID-19 and other viral infections:Efficacies and mechanisms [J]. Pharmacol Ther , 2021 , 225 : 107843 .
ZHANG L , ZHENG X , BAI X , et al . Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: A national retrospective registry study [J]. Phytomedicine , 2021 , 85 : 153531 .
MA Y , ZHU D S , CHEN R B , et al . Association of overlapped and un-overlapped comorbidities with COVID-19 severity and treatment outcomes:A retrospective cohort study from nine provinces in China [J]. Biomed Environ Sci , 2020 , 33 ( 12 ): 893 - 905 .
ZONG X , LIANG N , WANG J , et al . Treatment effect of Qingfei Paidu decoction combined with conventional treatment on COVID-19 patients and other respiratory diseases: A multi-center retrospective case series [J]. Front Pharmacol , 2022 , 13 : 849598 .
World Health Organization . WHO expert meeting on evaluation of traditional Chinese medicine in the treatment of COVID-19 [EB/OL].( 2022-03-31 ) [ 2023-11-29 ]. https://www.who.int/publications/m/item/who-expert-meeting-on-evaluation-of-traditional-chinese-medicine-in-the-treatment-of-covid-19 https://www.who.int/publications/m/item/who-expert-meeting-on-evaluation-of-traditional-chinese-medicine-in-the-treatment-of-covid-19 .
SHI N , LIU B , LIANG N , et al . Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19:A retrospective multicenter cohort study [J]. Pharmacol Res , 2020 , 161 : 105290 .
JANG S , KIM D , YI E , et al . Telemedicine and the use of korean medicine for patients with COVID-19 in south korea: Observational study [J]. JMIR Public Health Surveill , 2021 , 7 ( 1 ): e20236 .
WANG Q , ZHU H , LI M , et al . Efficacy and safety of Qingfei Paidu decoction for treating COVID-19: A systematic review and Meta-analysis [J]. Front Pharmacol , 2021 , 12 : 688857 .
孙易娜 , 吕文亮 , 李昊 , 等 . 清肺排毒汤治疗轻型/普通型新型冠状病毒肺炎295例多中心临床研究 [J]. 中医杂志 , 2021 , 62 ( 7 ): 599 - 603 .
葛又文 , 郑建 , 宗星煜 , 等 . 新型冠状病毒肺炎奥密克戎变异毒株无症状感染者使用清肺排毒颗粒时间与核酸转阴时间的相关性分析 [J]. 中医杂志 , 2022 , 63 ( 20 ): 1952 - 1957 .
余雪源 , 张硕 , 燕芳芳 , 等 . 采用清肺排毒汤联合西药43例与单用西药46例的新型冠状病毒肺炎临床疗效比较 [J]. 山东大学学报:医学版 , 2020 , 58 ( 12 ): 47 - 53 .
许源 , 宿树兰 , 王团结 , 等 . 桂枝的化学成分与药理活性研究进展 [J]. 中药材 , 2013 , 36 ( 4 ): 674 - 678 .
王丹 , 吴喜民 , 张东东 , 等 . 中药桂枝化学成分研究 [J]. 中国中药杂志 , 2020 , 45 ( 1 ): 124 - 132 .
蔡芷辰 , 李振麟 , 徐谦 , 等 . 桂枝的化学成分分析 [J]. 中国实验方剂学杂志 , 2014 , 20 ( 22 ): 57 - 60 .
肖飞艳 , 冯育林 , 杨世林 , 等 . 泽泻化学成分的研究进展 [J]. 中药新药与临床药理 , 2009 , 20 ( 5 ): 491 - 495 .
刘珊珊 , 郭杰 , 李宗艾 , 等 . 泽泻化学成分及药理作用研究进展 [J]. 国中药杂志 , 2020 , 45 ( 7 ): 1578 - 1595 .
ZHANG L L , XU W , XU Y L , et al . Therapeutic potential of Rhizoma Alismatis:A review on ethnomedicinal application,phytochemistry, pharmacology, and toxicology [J]. Ann N Y Acad Sci , 2017 , 1401 ( 1 ): 90 - 101 .
戴梦翔 , 金姝娜 , 宋成武 , 等 . 泽泻及其炮制品化学成分和药理作用的研究进展 [J]. 中草药 , 2023 , 54 ( 5 ): 1620 - 1635 .
FONG W F , WANG C , ZHU G Y , et al . Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract [J]. Phytomedicine , 2007 , 14 ( 2/3 ): 160 - 165 .
XU F , HOU T , SHEN A , et al . Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of coronavirus disease 2019 (COVID-19) by label-free integrative pharmacology assays [J]. J Ethnopharmacol , 2021 , 280 : 114488 .
徐锋 , 王德健 , 王凤 , 等 . 桂枝挥发油的药理作用研究进展 [J]. 中华中医药杂志 , 2016 , 31 ( 11 ): 4653 - 4657 .
孙传菊 , 赵懿清 , 张彩娣 , 等 . 桂枝挥发油对急性肺炎小鼠的抗炎作用机制研究 [J]. 中国临床药理学杂志 , 2018 , 34 ( 20 ): 2413 - 2416 .
徐锋 . 基于NLRP3炎症小体通路桂枝抗炎有效部位抗炎作用机制研究 [D]. 成都 : 成都中医药大学 , 2017 .
SONG F , LI H , SUN J , et al . Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats [J]. J Ethnopharmacol , 2013 , 150 ( 1 ): 125 - 130 .
GUO J Y , HUO H R , ZHAO B S , et al . Cinnamaldehyde reduces IL-1 β -induced cyclooxygenase-2 activity in rat cerebral microvascular endothelial cells [J]. Eur J Pharmacol , 2006 , 537 ( 1/3 ): 174 - 180 .
张畅斌 , 李沧海 , 隋峰 , 等 . 桂枝汤苯丙烯类化合物对环氧合酶-2及前列腺素抑制的作用 [J]. 中国实验方剂学杂志 , 2012 , 18 ( 9 ): 157 - 161 .
李丽萍 . 桂枝的药理作用分析及其临床应用研究 [J]. 中国医药指南 , 2017 , 15 ( 4 ): 180 - 181 .
HAN C W , KWUN M J , KIM K H , et al . Ethanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF- κ B and activating Nrf2 [J]. J Ethnopharmacol , 2013 , 146 ( 1 ): 402 - 410 .
MATSUDA H , KAGEURA T , TOGUCHIDA I , et al . Effects of sesquiterpenes and triterpenes from the rhizome of Alisma orientale on nitric oxide production in lipopolysaccharide-activated macrophages:Absolute stereostructures of alismaketones-B 23-acetate and -C 23-acetate [J]. Bioorg Med Chem Lett , 1999 , 9 ( 21 ): 3081 - 3086 .
KIM K H , KWUN M J , CHOI J Y , et al . Therapeutic effect of the tuber of alisma orientale on lipopolysaccharide-induced acute lung injury [J]. Evid Based Complement Alternat Med , 2013 , doi: 10.1155/2013/863892 http://dx.doi.org/10.1155/2013/863892 .
KIM K H , SONG H H , AHN K S , et al . Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model [J]. J Ethnopharmacol , 2016 , 188 : 21 - 30 .
BAILLY C . Pharmacological properties and molecular targets of alisol triterpenoids from Alismatis Rhizoma [J]. Biomedicines , 2022 , 10 ( 8 ): 1945 .
林娜 , 黄锦芳 , 张雪 , 等 . 泽泻总三萜的抗炎活性研究 [J]. 福建中医药 , 2018 , 49 ( 4 ): 68 - 69,71 .
谢治深 , 黄小虹 , 袁永 , 等 . 泽泻抑制脂多糖诱导的RAW264.7炎症及作用机制 [J]. 时珍国医国药 , 2020 , 31 ( 7 ): 1586 - 1590 .
SHIN M H , PARK Y J , KIM K S . The anti-inflammatory effects of Alisma herb extract on allergic asthma mouse model [J]. Mol Cell Toxicol , 2014 , 10 ( 2 ): 197 - 206 .
黄小强 , 朱怀昌 , 许文 , 等 . 泽泻总三萜对脂多糖诱导的小鼠急性肺损伤的保护作用 [J]. 福建中医药 , 2020 , 51 ( 6 ): 37 - 39 .
BI X , WANG P , MA Q , et al . Anti-inflammatory activities and liver protection of alisol f and 25-anhydroalisol F through the Inhibition of MAPK, STAT3, and NF- κ B acti vation in vitro and in vivo [J]. Molecules , 2017 , 22 ( 6 ): 951 .
XUE X H , ZHOU X M , WEI W , et al . Alisol A 24-acetate, a triterpenoid derived from alisma orientale, inhibits Ox-LDL-induced phenotypic transformation and migration of rat vascular smooth muscle cells through suppressing ERK1/2 signaling [J]. J Vasc Res , 2016 , 53 ( 5/6 ): 291 - 300 .
DOU F , MIAO H , WANG J W , et al . An integrated lipidomics and phenotype study reveals protective effect and biochemical mechanism of traditionally used alisma orientale juzepzuk in chronic kidney disease [J]. Front Pharmacol , 2018 , 9 : 53 .
MENG Q , DUAN X P , WANG C Y , et al . Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation [J]. Acta Pharmacol Sin , 2017 , 38 ( 1 ): 69 - 79 .
YANG Y , ZHANG D M , LIU J H , et al . Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice [J]. J Ethnopharmacol , 2015 , 169 : 49 - 59 .
沈梦玥 , 张密 , 唐志宇 , 等 . 真武汤合五苓散联合西医常规疗法治疗慢性阻塞性肺疾病急性加重期阳虚水泛证的临床观察 [J]. 中国民间疗法 , 2020 , 28 ( 24 ): 88 - 91 .
骆和生, 中药方剂的药理与临床研究进展 [M]. 广州 : 华南理工大学出版社 , 1991 : 49 .
刘蓉 , 何婷 , 曾南 , 等 . 桂枝挥发油及桂皮醛抗流感病毒的机制研究 [J]. 中草药 , 2013 , 44 ( 11 ): 1460 - 1464 .
刘蓉 , 苟玲 , 于柳 , 等 . 桂枝挥发油与桂皮醛对病毒性肺炎小鼠死亡保护作用及TLR/IFN信号机制研究 [J]. 中药药理与临床 , 2013 , 29 ( 4 ): 33 - 36 .
卢长安 . 桂枝汤的药理研究六 [J]. 中药药理与临床 , 1990 , 6 ( 1 ): 2 .
王俨如 , 李娜 , 曹亮 等 . 应用高内涵技术研究桂枝茯苓胶囊抗炎及免疫调节活性成分 [J]. 中国中药杂志 , 2015 , 40 ( 6 ): 1005 - 1011 .
TOMODA M , GONDA R , SHIMIZU N , et al . Characterization of anacidic polysa ccharide having immunological activities from the tuber of Alisma orientale [J]. Biol Pharm Bull , 1994 , 17 ( 5 ): 572 .
SHIMIZU N , OHTSU S , TOMODA M , et al . A glucan with immuno-logical activities from the tuber of Alisma orientalel [J]. Biol Pharm Bul1 , 1994 , 17 ( 12 ): 1666 .
张朝凤 , 周爱存 , 张勉 . 泽泻的化学成分及其免疫抑制活性筛选 [J]. 中国中药杂志 , 2009 , 34 ( 8 ): 994 - 998 .
徐晗 , 章蕴毅 , 张建文 , 等 . 天然产物中的抗补体活性成分 [J]. 中国天然药物 , 2007 , 5 : 322 - 332 .
MATSUDA H , TOMOHIRO N , YOSHIKAWA M , et al . Studies on Alismatis Rhizoma. Ⅱ. anti-complementary activities of methanol extract and terpene components from Alismatis Rhizoma (dried rhizome of Alisma orientale ) [J]. Biol Pharm Bull , 1998 , 21 ( 12 ): 1317 - 1321 .
KUBO M , MATSUDA H , TOMOHIRO N , et al . Studies on Alismatis Rhizoma. I. anti-allergic effects of methanol extract and six terpene components from Alismatis Rhizoma (dried rhizome of Alisma Orientale) [J]. Biol Pharm Bull , 1997 , 20 ( 5 ): 511 - 6 .
尹春萍 , 吴继洲 . 泽泻及其活性成分免疫调节作用研究进展 [J]. 中草药 , 2001 , 32 ( 12 ): 79 - 80 .
LEE J H , KWON O S , JIN H G , et al . The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis [J]. Biol Pharm Bull , 2012 , 35 ( 9 ): 1581 - 1587 .
孙建民 . 五苓散加味对轮状病毒腹泻患儿外周血T淋巴细胞亚群的影响 [J]. 河南中医 , 2016 , 36 ( 5 ): 766 - 767 .
YEH C F , CHANG J S , WANG K C , et al . Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation [J]. J Ethnopharmacol , 2013 , 147 ( 2 ): 321 - 326 .
DU Q , LIANG R , WU M , et al . Alisol B 23-acetate broadly inhibits coronavirus through blocking virus entry and suppresses proinflammatory T cells responses for the treatment of COVID-19 [J]. J Adv Res , 2024 , 62 : 273 - 290 .
赵静 , 田赛赛 , 杨健 , 等 . 清肺排毒汤治疗新型冠状病毒肺炎机制的网络药理学探讨 [J]. 中草药 , 2020 , 51 ( 4 ): 829 - 835 .
高乾峰 . 茵陈五苓散加减联合阿德福韦酯对慢性乙型肝炎病毒复制及免疫功能的影响 [J]. 现代中西医结合杂志 , 2018 , 27 ( 6 ): 597 - 600 .
王琍文 , 苏成业 . 泽泻、豬苓、茯苓、桂枝及其复方五苓散的利尿作用 [J]. 大连医科大学学报 , 1965 , 5 ( 1 ): 40 - 46 .
陈少丽 , 陈德兴 , 陈佳靓 , 等 . 五苓散中桂枝的配伍对水负荷和阳虚模型小鼠利水作用的影响 [J]. 上海中医药杂志 , 2014 , 48 ( 1 ): 78 - 80,84 .
ZHANG X , LI X Y , LIN N , et al . Diuretic activity of compatible triterpene components of Alismatis Rhizoma [J]. Molecules , 2017 , 22 ( 9 ): 1459 .
黄小强 , 张雪 , 李小艳 , 等 . 泽泻不同提取部位对大鼠的利尿作用 [J]. 福建中医药 , 2016 , 47 ( 5 ): 21 - 23 .
王立新 , 吴启南 , 张桥 , 等 . 泽泻中利尿活性物质的研究 [J]. 华西药学杂志 , 2008 , 23 ( 6 ): 670 - 672 .
刘新华 , 张宁 , 马越鸣 , 等 . 桂枝特征化学成分与解热效应相关性研究 [J]. 中华中医药学刊 , 2012 , 30 ( 1 ): 199 - 201 .
韦静虹 , 杨柯 , 朱海滨 , 等 . 基于网络药理学和体内实验研究桂枝解热的作用机制 [J]. 广西医科大学学报 , 2023 , 40 ( 1 ): 93 - 100 .
池明哲 , 金范学 . 桂枝乙醇提取物对大鼠离体胸主动脉环的舒张作用 [J]. 延边大学医学学报 . 2010 , 33 ( 4 ): 256 - 258 .
夏天卫 , 周国威 , 姚晨 , 等 . 桂枝及肉桂治痹的中医认识与现代药学研究进展 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 6 ): 218 - 226 .
徐世军 . 桂枝挥发油对TLR2、TLR4基因表达及其信号转导通路的影响 [D]. 成都 : 成都中医药大学 , 2006 .
TIAN T , CHEN H , ZHAO Y Y . Traditional uses, phytochemistry,pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep:A review [J]. J Ethnopharmacol , 2014 ,158 Pt A:373- 387 .
祝建辉 , 鲍晓荣 , 何华平 , 等 . 泽泻肾毒性研究 [J]. 中药药理与临床 , 2007 , 23 ( 3 ): 60 - 62 .
乐智勇 , 宋成武 , 姜淋洁 , 等 . 泽泻水提物对不同性别小鼠肾脏的慢性毒性研究 [J]. 湖北中医杂志 , 2012 , 34 ( 7 ): 22 - 23 .
AHMED S , UCHIDA R , HUSSAIN M , et al . Evaluation of the safety and adverse effects of goreisan/wulingsan,a traditional Japanese-chinese herbal formulation (kampo), in a rat model:A toxicological evaluation [J]. Trop Med Health , 2014 , 42 ( 3 ): 127 - 132 .
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