1.河南中医药大学,郑州 450046
2.豫药全产业链研发河南省协同创新中心,郑州 450046
王浩阳,在读硕士,从事中药学研究,E-mail:1124496439@qq.com
苗明三,博士,教授,从事中药药理教学与研究,E-mail: miaomingsan@163.com
收稿:2024-05-15,
录用:2024-07-12,
网络出版:2024-07-17,
纸质出版:2025-03-05
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王浩阳,郭琳,赵晖等.基于Wnt/β-catenin信号通路靶向的中药有效成分及中药复方防治乳腺癌特点分析[J].中国实验方剂学杂志,2025,31(05):282-290.
WANG Haoyang,GUO Lin,ZHAO Hui,et al.Characteristic Analysis of Effective Components and Compounds of TCM for Prevention and Treatment of Breast Cancer Based on Wnt/β-catenin Signaling Pathway Targeting[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(05):282-290.
王浩阳,郭琳,赵晖等.基于Wnt/β-catenin信号通路靶向的中药有效成分及中药复方防治乳腺癌特点分析[J].中国实验方剂学杂志,2025,31(05):282-290. DOI: 10.13422/j.cnki.syfjx.20241626.
WANG Haoyang,GUO Lin,ZHAO Hui,et al.Characteristic Analysis of Effective Components and Compounds of TCM for Prevention and Treatment of Breast Cancer Based on Wnt/β-catenin Signaling Pathway Targeting[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(05):282-290. DOI: 10.13422/j.cnki.syfjx.20241626.
乳腺癌是一种机制复杂的恶性肿瘤,发病率和死亡率逐年上升,严重威
胁女性的健康。目前临床治疗常以手术切除、放疗化疗、药物治疗为主,但往往伴随着不良反应,影响治疗效果。中药在对抗乳腺癌方面,具有多成分、多靶点的治疗优势,Wnt/
β
-连环蛋白(
β
-catenin)信号通路是癌症研究的经典通路之一,异常激活的Wnt/
β
-catenin信号通路通过阻断轴蛋白/糖原合成酶激酶-3
β
/结直肠腺瘤性息肉基因蛋白复合物的形成,抑制
β
-catenin降解,促进
β
-catenin核转移,并与T细胞转录因子/淋巴增强因子-1结合,启动下游靶基因,进一步干预肿瘤细胞的增殖、迁移和侵袭等过程影响肿瘤进程。既往研究表明中药单体及复方可介导Wnt/
β
-catenin信号通路抑制乳腺癌细胞的恶性表型,从而发挥抗乳腺癌的作用,对于治疗药物参与调控的生化过程尚未开展系统的梳理。该文通过分析整理现阶段的国内外文献资料,探讨Wnt/
β
-catenin信号通路与乳腺癌的关联机制,解析中药单体及中药复方介导Wnt/
β
-catenin信号通路发挥抗乳腺癌的内在机制,统计结果发现中药单体的黄酮、生物碱、萜类成分能够靶向Wnt/
β
-catenin信号通路阻滞乳腺癌细胞恶性表型的进一步发展,临床常用具有清热解毒、活血化瘀、滋补肾肝等功效的中药复方干预Wnt/
β
-catenin信号通路从而抵抗乳腺癌。对比目前Wnt/
β
-catenin信号通路抑制剂,中药单体及中药复方的应用有望为临床带来低毒高效的乳腺癌治疗药物,现有结果为后续筛选、研发抗乳腺癌的中药来源小分子化合物及中药复方提供参考。
Breast cancer is a kind of malignant tumor with a complex mechanism, and its morbidity and mortality are increasing year by year, which seriously threatens women's health. At present, the main clinical treatments are surgical resection, radiotherapy, chemotherapy, and drug therapy, but they are often accompanied by side effects and adverse reactions, which affect the therapeutic effect. Traditional Chinese medicine (TCM) has the advantages of multi-component and multi-target treatment in the fight against breast cancer. The wnt/
β
-catenin signaling pathway is one of the classic pathways in cancer research. Abnormally activated Wnt/
β
-catenin signaling pathway inhibits
β
-catenin degradation by blocking the formation of Axin/glycogen synthase kinase 3
β
/adenomatous polyposis coli complex, thus promoting
β
-catenin nuclear metastasis, and it binds to T cell transcription factor/lymphoenhancer factor-1 to initiate downstream target genes and further interfere with the proliferation, migration, and invasion of tumor cells to affect t
he tumor process. Previous studies have shown that TCM monomers and compounds can mediate the Wnt/
β
-catenin signaling pathway to inhibit the malignant phenotype of breast cancer cells, thus playing an anti-breast cancer role, and the biochemical process involved in the regulation of therapeutic drugs has not been systematically combed. By analyzing and collating Chinese and foreign literature at the present stage, this paper discussed the association mechanism between Wnt/
β
-catenin signaling pathway and breast cancer and analyzed the internal mechanism of TCM monomers and compounds in mediating Wnt/
β
-catenin signaling pathway to exert anti-breast cancer effect. The statistical results showed that the flavonoids, alkaloids, and terpenoids in TCM monomers could target the Wnt/
β
-catenin signaling pathway and block the further development of malignant phenotype of breast cancer cells. TCM compounds with functions of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and tonifying kidney and liver were commonly used to intervene in the Wnt/
β
-catenin signaling pathway to prevent breast cancer. Compared with the current inhibitors of Wnt/
β
-catenin signaling pathway, the application of TCM monomers and compounds is expected to bring low-toxicity and high-efficiency breast cancer treatment drugs to the clinical practice, and the existing results provide a reference for the subsequent screening, research, and development of TCM small-molecule compounds and TCM compounds against breast cancer.
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