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1.山东中医药大学 第一临床医学院,济南 250014
2.山东中医药大学 中医学院,济南 250014
3.山东中医药大学 附属医院,济南 250012
窦鑫,在读硕士,从事中医治疗消化系统疾病的研究,E-mail:3109876827@qq.com
邓华亮,博士,主任医师,从事消化系统疾病中西医结合临证诊疗研究,E-mail:dhl1002@sina.cn
王伟,博士,副主任医师,从事中医治疗消化系统疾病的研究,E-mail:smiling365@163.com;
收稿日期:2025-01-20,
录用日期:2025-02-17,
网络出版日期:2025-03-10,
纸质出版日期:2025-07-20
移动端阅览
窦鑫,潘海迪,贺昌辉等.基于“异病同治”探讨三仁汤临床应用及作用机制研究进展[J].中国实验方剂学杂志,2025,31(14):243-254.
DOU Xin,PAN Haidi,HE Changhui,et al.Clinical Application and Mechanism of Sanrentang Based on Treating Different Diseases with Same Therapy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(14):243-254.
窦鑫,潘海迪,贺昌辉等.基于“异病同治”探讨三仁汤临床应用及作用机制研究进展[J].中国实验方剂学杂志,2025,31(14):243-254. DOI: 10.13422/j.cnki.syfjx.20251199.
DOU Xin,PAN Haidi,HE Changhui,et al.Clinical Application and Mechanism of Sanrentang Based on Treating Different Diseases with Same Therapy: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(14):243-254. DOI: 10.13422/j.cnki.syfjx.20251199.
三仁汤始载于清代吴鞠通所著的《温病条辨》,是治疗湿温初起或暑温夹湿,邪在气分,湿重于热的经典名方,具有宣畅气机、清利湿热的功效,可治疗以头痛恶寒,面色淡黄,身重疼痛,肢体倦怠,胸闷不饥,午后身热,苔白不渴,脉弦细而濡等为主要表现的病证。中医学提倡“整体观念”与“辨证论治”,针对不同的疾病进行精准辨证,把握其病机特点处以方药治疗。现代临床将三仁汤广泛应用于湿热蕴结、气机不利所致的心系、肺系、脾胃系、肝胆系、肾系、肠腑、糖尿病及其并发症、皮肤类等多系统疾病,并取得了显著效果,尤其对于一些以湿热证表现为主但疗效不佳的难治性疾病,可应用三仁汤联合治疗,延缓病情发展,延长生存期,发挥中医药特色优势,充分体现“证同则治同”的“异病同治”诊疗思想。现代药理学研究表明三仁汤具有抗炎、抗氧化,增强免疫机能,修复黏膜屏障,调节胃肠动力,维持代谢平衡等作用,证实中药复方具有多靶点、多层次、多成分、多途径等特点,可治疗具有炎症改变、免疫失衡等相同病理基础的多系统疾病。通过探讨三仁汤的“异病同治”,对临床应用三仁汤治疗多系统疾病及其作用机制研究的相关文献进行系统回顾与梳理,以期为应用经方治疗多系统疾病,挖掘经方深层次内涵,建立具有中医药特色的精准诊疗体系,促进中医药传承创新发展提供思路与借鉴。
Sanrentang was first recorded in
Detailed Analysis of Warm Diseases
(
Wen Bing Tiao Bian
), a work by Wu Jutong in the Qing Dynasty. It is a classic formula for treating the early stages of dampness-warmth or summer heat-warmth with dampness, characterized by pathogenic factors in the Qi aspect and more dampness than heat. This formula has the effects of dispersing Qi and clearing dampness and heat, and it can thus address symptoms such as headache, aversion to cold, pale yellow complexion, heavy body, pain, fatigue, chest fullness with loss of appetite, af
ternoon fever, white tongue coating without thirst, and a wiry, thready, and soggy pulse. Traditional Chinese medicine (TCM) emphasizes the holistic approach and treatment based on syndrome differentiation, using precise diagnostic methods to understand the characteristics of disease mechanisms and provide targeted treatment with herbal formulas. In modern clinical practice, Sanrentang has been widely employed to treat multi-system diseases caused by dampness-heat accumulation and obstructed Qi movement, including disorders of the heart, lung, spleen, stomach, liver, gallbladder, kidney, and intestine, diabetes and its complications, and dermatological conditions, achieving remarkable therapeutic outcomes. Particularly, for refractory diseases characterized predominantly by dampness-heat syndromes with poor treatment outcomes, the combined use of Sanrentang can delay disease progression, extend the survival time, and highlight the advantages of TCM, fully embodying the diagnostic and therapeutic principle of treating different diseases with same therapy based on the concept that identical patterns warrant identical therapy. Modern pharmacological studies have demonstrated that Sanrentang exerts anti-inflammatory and antioxidant effects, enhances the immune function, repairs the mucosal barrier, regulates the gastrointestinal motility, and maintains the metabolic balance. These findings confirm that TCM compound formulas possess multi-target, multi-dimensional, multi-component, and multi-pathway characteristics, effectively treating multi-system diseases with common pathological foundations such as inflammation and immune imbalance. This paper reviews the relevant literature on the clinical application of Sanrentang in the treatment of multi-system diseases and its mechanism and explores treating different diseases with same therapy (Sanrentang). This review aims to provide insights and references for using TCM compound formulas in treating multi-system diseases, exploring the deeper implications of these formulas
, establishing a TCM-based precise diagnosis and treatment system, and promoting the inheritance and innovative development of TCM.
郑洪新 , 杨柱 . 中医基础理论 [M]. 北京 : 中国中医药出版社 , 2021 : 12 - 13 .
ZHENG H X , YANG Z . Basic theory of traditional Chinese medicine [M]. Beijing : China Press of Chinese Medicine , 2021 : 12 - 13 .
陈旻 . 同病异治与异病同治在《金匮要略》中的应用 [J]. 光明中医 , 2021 , 36 ( 18 ): 3070 - 3072 .
CHEN M . The Application of treating different diseases with the same method and treating the same disease with different therapies in synopsis of Golden Chamber [J]. Guangming J Chin Med , 2021 , 36 ( 18 ): 3070 - 3072 .
周莎 , 罗秋月 , 吉萌萌 , 等 . 关于吴茱萸汤临床应用与开发利用的思考 [J]. 中国中医基础医学杂志 , 2021 , 27 ( 5 ): 841 - 845 .
ZHOU S , LUO Q Y , JI M M , et al . Thoughts on the clinical application,development and utilization of Wuzhuyu decoction [J]. Chin J Bas Med Tradit Chin Med , 2021 , 27 ( 5 ): 841 - 845 .
安东阳 , 齐峰 . 浅谈对异病同治的理解及应用 [J]. 中国中医药现代远程教育 , 2018 , 16 ( 5 ): 74 - 75 .
AN D Y , QI F . Discussion on the understanding and application of the homotherapy for heteropathy [J]. Chin Med Mod Dist Edu China , 2018 , 16 ( 5 ): 74 - 75 .
刘婷 , 孙月婷 , 陆为民 . 国医大师徐景藩“谨守病机,异病同治”一隅 [J]. 中华中医药杂志 , 2022 , 37 ( 7 ): 3846 - 3849 .
LIU T , SUN Y T , LU W M . Embodiment of TCM master XU Jing-fan's "observing the pathogenesis,treating different diseases the same way "[J]. China J Tradit Chin Med Pharm , 2022 , 37 ( 7 ): 3846 - 3849 .
王子君 , 史乾灵 , 宫恩莹 , 等 . 共病指南:现状、挑战与机遇 [J]. 中国循证医学杂志 , 2024 , 24 ( 6 ): 621 - 625 .
WANG Z J , SHI Q L , GONG E Y , et al . Multimorbidity guidelines:Past,present and future [J]. Chin J Evid Bas Med , 2024 , 24 ( 6 ): 621 - 625 .
王志如 , 贾小芳 , 刘梦冉 , 等 . 2018年我国15省45~64岁中年人共病现状及其影响因素——基于关联规则分析 [J]. 环境与职业医学 , 2024 , 41 ( 7 ): 768 - 773 .
WANG Z R , JIA X F , LIU M R , et al . Multimorbidity status and risk factors among adults aged 45-64 years in 15 provinces of China in 2018:Based on association rule analysis [J]. J Environ Occup Med , 2024 , 41 ( 7 ): 768 - 773 .
王霁一 , 冯星淋 . 我国中老年人慢性病共病患病率的变化趋势及影响因素分析 [J]. 医学与社会 , 2024 , 37 ( 7 ): 41 - 48 .
WANG J Y , FENG X L . Analysis on trends and influencing factors of prevalence of multimorbidity of chronic diseases among middle-aged and elderly people in China [J]. Med Soc , 2024 , 37 ( 7 ): 41 - 48 .
赵卫华 , 刘南飞 , 李尤佳 , 等 . 从气血同治探讨慢性气道疾病的异病同治 [J]. 世界中医药 , 2024 , 19 ( 9 ): 1293 - 1296 .
ZHAO W H , LIU N F , LI Y J , et al . Homotherapy of different diseases for chronic airway diseases from simultaneous treatment of Qi and blood [J]. World Chin Med , 2024 , 19 ( 9 ): 1293 - 1296 .
胡丽丽 , 王珏 , 吴娜 , 等 . 网络药理学结合实验验证探讨四逆散“异病同治”抑郁症、焦虑症和乳腺纤维囊性疾病的作用机制 [J]. 药物评价研究 , 2024 , 47 ( 8 ): 1735 - 1748 .
HU L L , WANG J , WU N , et al . Exploring mechanism of Sini Powder in treatment of depression,anxiety disorder,and breast fibrocystic disease based on network pharmacology and experimental verification [J]. Drug Evalu Res , 2024 , 47 ( 8 ): 1735 - 1748 .
丁子涵 , 王楠 , 杨骏 , 等 . 芍药甘草汤在消化系统疾病中的应用及其作用机制研究进展 [J]. 中国中药杂志 , 2024 , 49 ( 23 ): 6311 - 6319 .
DING Z H , WANG N , YANG J , et al . Shaoyao Gancao decoction in digestive system diseases:applications and mechanisms [J]. China J Chin Mater Med , 2024 , 49 ( 23 ): 6311 - 6319 .
李伟泽 , 赵宁 , 韩文霞 , 等 . 现代中药制剂创新研发模式“证-药-方-剂”的构建 [J]. 中药材 , 2024 , 47 ( 4 ): 803 - 809 .
LI W Z , ZHAO N , HAN W X , et al . Construction of modern traditional Chinese medicine innovative research and development mode of "syndrome-medicine-prescription-preparation "[J]. J Chin Med Mater , 2024 , 47 ( 4 ): 803 - 809 .
吴瑭 . 温病条辨 [M]. 北京 : 人民卫生出版社 , 2010 : 42 .
WU T . Wenbing Tiaobian [M]. Beijing : People's Medical Publishing House , 2010 : 42 .
田海艳 , 林晓玲 , 容伟明 , 等 . 《伤寒论》甘澜水之研究进展 [J]. 中国民族民间医药 , 2017 , 26 ( 10 ): 54 - 55 .
TIAN H Y , LIN X L , RONG W M , et al . Research progress on Ganlan Water in Treatise on Febrile Diseases [J]. Chin J Ethnomed Ethnopharm , 2017 , 26 ( 10 ): 54 - 55 .
丁慧登 , 范永升 . 从甘澜水之古今观浅谈汤药煎服方法 [J]. 中国中医基础医学杂志 , 2010 , 16 ( 5 ): 425 - 426 .
DING H D , FAN Y S . Discuss method of making a decoction and administration by ancient and contemporary understanding of Ganlan water [J]. Chin J Bas Med Tradit Chin Med , 2010 , 16 ( 5 ): 425 - 426 .
谭雯 , 蔡明阳 , 刘珍洪 , 等 . 从纳米气泡水的增溶特性理解甘澜水的煎药意义 [J]. 中国中医基础医学杂志 , 2023 , 29 ( 8 ): 1303 - 1306 .
TAN W , CAI M Y , LIU Z H , et al . Understanding of decocting significance of Ganlan water from solubilization characteristics of nano bubble water [J]. Chin J Bas Med Tradit Chin Med , 2023 , 29 ( 8 ): 1303 - 1306 .
张平 , 谭琰 , 高峰 , 等 . 三仁汤中三焦理论的临床应用及优势探讨 [J]. 中国实验方剂学杂志 , 2021 , 27 ( 7 ): 193 - 200 .
ZHANG P , TAN T , GAO F , et al . Clinical application and advantages of Sanjiao theory in Sanrentang [J]. Chin J Exp Tradit Med Form , 2021 , 27 ( 7 ): 193 - 200 .
叶天士 . 临证指南医案 [M]. 北京 : 人民卫生出版社 , 2006 : 228 .
YE T S . Linzheng Zhinan Yian [M]. Beijing : People's Medical Publishing House , 2006 : 228 .
马宗元 . 温病辨症 [M]. 上海 : 上海科学技术出版社 , 2004 : 316 .
MA Z Y . Wenbing Bianzheng [M]. Shanghai : Shanghai Scientific & Technical Publishers , 2004 : 316 .
何廉臣 . 重订广温热论 [M]. 福州 : 福建科学技术出版社 , 2005 : 98 .
HE L C . Chongding Guangwenrelun [M]. Fuzhou : Fujian Science & Technology Publishing Horse , 2005 : 98 .
秦伯未 . 谦斋医学讲稿 [M]. 上海 : 上海科学技术出版社 , 1978 : 145 .
QIN B W . Qianzhai Yixue Jianggao [M]. Shanghai : Shanghai Scientific & Technical Publishers , 1978 : 145 .
赵绍琴 . 温病纵横 [M]. 北京 : 人民卫生出版社 , 1982 : 21 .
ZHAO S Q . Wenbing Zongheng [M]. Beijing : People's Medical Publishing House , 1982 : 21 .
刘景源 . 刘景源温病学讲稿 [M]. 北京 : 人民卫生出版社 , 2008 : 208 .
LIU J Y . LIU Jingyuan's lecture on warm diseases [M]. Beijing : People's Medical Publishing House , 2008 : 208 .
王猛 , 张思超 . 基于湿热证的三仁汤研究进展 [J]. 辽宁中医药大学学报 , 2024 , 26 ( 4 ): 124 - 131 .
WANG M , ZHANG S C . Progress in the study of Sanrentang(三仁汤) based on damp-heat syndrome [J]. J Liaoning Univ Tradit Chin Med , 2024 , 26 ( 4 ): 124 - 131 .
陈晶晶 , 张文风 , 张茂云 , 等 . 治疫经方三仁汤证治规律浅析 [J]. 长春中医药大学学报 , 2022 , 38 ( 2 ): 123 - 126 .
CHEN J J , ZHANG W F , ZHANG M Y , et al . Analysis on the laws of Sanrentang in differentiating and treating epidemic diseases [J]. J Changchun Univ Chin Med , 2022 , 38 ( 2 ): 123 - 126 .
郭悦 , 刘纯兴 , 于艳丽 . 基于DID模型加味三仁汤对冠心病患者左心室重构的影响分析 [J]. 四川中医 , 2022 , 40 ( 8 ): 74 - 78 .
GUO Y , LIU C X , YU Y L . Influence analysis of modified Sanrentang on left ventricular remodeling for patients with coronary heart disease based on DID model [J]. J Sichuan Tradit Chin Med , 2022 , 40 ( 8 ): 74 - 78 .
黄功超 . 加味三仁汤治疗冠心病慢性心力衰竭三焦湿热证的疗效研究 [J]. 北方药学 , 2019 , 16 ( 4 ): 15 - 16 .
HUANG G C . The efficacy study of adding flavor sangren decoction for treating chronic heart failure of coronary heart disease with trifocal heat syndrome [J] . J North Pharm , 2019 , 16 ( 4 ): 15 - 16 .
吕俊芳 , 朱明军 . 加味三仁汤治疗冠心病慢性心力衰竭三焦湿热证临床研究 [J]. 陕西中医 , 2018 , 39 ( 5 ): 596 - 598 .
LV J F , ZHU M J . The clinical effect of adding flavor sangren decoction for treating chronic heart failure of coronary heart disease with trifocal heat syndrome [J]. Shaanxi J Tradit Chin Med , 2018 , 39 ( 5 ): 596 - 598 .
吴晓燕 , 徐雯 . 加减三仁汤治疗湿热侵心型小儿病毒性心肌损伤临床观察 [J]. 中国现代药物应用 , 2020 , 14 ( 2 ): 196 - 197 .
WU X Y , XU W . Clinical observation on the treatment of viral myocardial injury in children with dampness-heat invasion by adding orsubtracting Sanrentang [J]. Chin J Mod Drug Appl , 2020 , 14 ( 2 ): 196 - 197 .
毛晨晗 , 龙丹 , 马文祺 , 等 . 董其美应用三仁汤“角药”配伍思维辨治心系病湿证经验 [J]. 中医药导报 , 2022 , 28 ( 8 ): 137 - 139,147 .
MAO C H , LONG D , MA W Q , et al . DONG Qimei's experience in treating heart disease dampness syndrome with the combination thinking of sanrentang and "Jiao Yao" [J]. Guid J Tradit Chin Med Pharm , 2022 , 28 ( 8 ): 137 - 139,147 .
刘玉萍 , 王静 , 龚信强 . 三仁汤灌肠对支气管肺炎患儿C-反应蛋白及降钙素原的影响 [J]. 云南中医中药杂志 , 2021 , 42 ( 6 ): 28 - 31 .
LIU Y P , WANG J , GONG X Q . Effect of Sanrentang enema on C-reactive protein and procalcitonin in child patients with bronchial pneumonia [J]. Yunnan J Tradit Chin Med Mater Med , 2021 , 42 ( 6 ): 28 - 31 .
戴广川 , 张向荣 , 高卫卫 , 等 . 银翘散联合三仁汤加减治疗新型冠状病毒肺炎普通型湿毒郁肺证20例 [J]. 安徽中医药大学学报 , 2020 , 39 ( 5 ): 1 - 4 .
DAI G C , ZHANG X R , GAO W W , et al . Clinical effect of Yinqiao powder combined with modified Sanrentang in treatment of common-type coronavirus disease 2019 with dampness-toxicity stagnation in lung:An analysis of 20 cases [J]. J Anhui Univ Chin Med , 2020 , 39 ( 5 ): 1 - 4 .
于忠翠 . 肺脾气虚型慢性咳嗽患儿以三仁汤加减治疗对其免疫功能和肺功能的影响 [J]. 现代医学与健康研究电子杂志 , 2023 , 7 ( 8 ): 89 - 91 .
YU Z C . The effect of modified Sanrentang on immune function and lung function in children with chronic cough of lung-spleen qi deficiency syndrome [J]. Mod Med Health Res Elec J , 2023 , 7 ( 8 ): 89 - 91 .
黄晖 , 刘忠达 , 李权 , 等 . 三仁汤加味对肥胖型慢性阻塞性肺疾病急性加重期痰热壅肺证患者临床疗效及肺功能的影响 [J]. 浙江中医杂志 , 2021 , 56 ( 8 ): 572 - 573 .
HUANG H , LIU Z D , LI Q , et al . The clinical efficacy and pulmonary function of modified Sanrentang on patients with phlegm heat obstructing the lungs syndrome in acute exacerbation of obese chronic obstructive pulmonary disease [J]. Zhejiang J Tradit Chin Med , 2021 , 56 ( 8 ): 572 - 573 .
郭心怡 , 刘长兴 , 赵丹 , 等 . 加味三仁汤治疗脾虚湿热兼肝郁型慢性非萎缩性胃炎临床观察 [J]. 河北中医 , 2023 , 45 ( 7 ): 1097 - 1101 .
GUO X Y , LIU C X , ZHAO D , et al . Clinical efficacy of modified Sanrentang for chronic non-atrophic gastritis of spleen deficiency damp-heat and liver stagnation [J]. Hebei J Tradit Chin Med , 2023 , 45 ( 7 ): 1097 - 1101 .
姚渭芬 , 章小飞 . 三仁汤加味联合四联疗法治疗脾胃湿热型幽门螺杆菌阳性慢性非萎缩性胃炎临床研究 [J]. 新中医 , 2022 , 54 ( 4 ): 25 - 28 .
YAO W F , ZHANG X F . Clinical study on modified Sanren Tang combined with quadruple therapy for helicobacter pylori positive chronic non-atrophic gastritis of spleen-stomach dampness-heat type [J]. J New Chin Med , 2022 , 54 ( 4 ): 25 - 28 .
徐溶慧 , 谢英瑛 . 三仁汤联合莫沙必利治疗功能性消化不良的临床效果 [J]. 临床医学研究与实践 , 2021 , 6 ( 28 ): 132 - 134 .
XU R H , XIE Y Y . Clinical effect of Sanrentang combined with mosapride in the treatment of functional dyspepsia [J]. Clin Res Pract , 2021 , 6 ( 28 ): 132 - 134 .
叶淑丽 , 龙劲锋 , 沈晓林 . 三仁汤联合莫沙必利对功能性消化不良患者中医证候积分及胃肠激素水平的影响 [J]. 中国社区医师 , 2021 , 37 ( 2 ): 116 - 117 .
YE S L , LONG J F , SHEN X L . Effect of Sanrentang combined with mosapride on traditional Chinese medicine syndrome score and gastrointestinal hormone level in patients with functional dyspepsia [J]. Chin Commun Doct , 2021 , 37 ( 2 ): 116 - 117 .
姚健 . 三仁汤加减方联合布拉氏酵母菌治疗脾胃湿热型小儿功能性消化不良的临床疗效及对胃肠激素水平的影响 [J]. 中国民间疗法 , 2021 , 29 ( 16 ): 79 - 81 .
YAO J . Clinical efficacy of San Ren Tang reduction formula combined with Saccharomyces boulardii in the treatment of functional dyspepsia in children with spleen stomach damp heat type and its impact on gastrointestinal hormone levels [J]. China Naturopathy , 2021 , 29 ( 16 ): 79 - 81 .
姚春苗 , 杨玲 , 尚雪妍 , 等 . 三仁汤合茵陈五苓散加减联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病(湿热蕴结证)的疗效及对肝纤维化和血清IL-1 β 、内脂素、HO-1水平的影响 [J]. 中国肝脏病杂志:电子版 , 2023 , 15 ( 3 ): 56 - 63 .
YAO C M , YANG L , SHANG X Y , et al . Sanrentang and Yinchen Wuling powder combined with polyene phosphatidylcholine in the treatment of non-alcoholic fatty liver disease(dampness-heat retention syndrome)and the effects on liver fibrosis and serum levels of IL-1 β ,visfatin and HO-1 [J]. Chin J Hepatol(Elec Ver) , 2023 , 15 ( 3 ): 56 - 63 .
林麟 , 胡岗 , 蒋凉凉 , 等 . 茵陈蒿汤合三仁汤联合体腔热灌注治疗肝胆湿热型肝癌恶性腹水的临床研究 [J]. 中国医学创新 , 2022 , 19 ( 24 ): 15 - 20 .
LIN L , HU G , JIANG L L , et al . Clinical study of Yinchenhao decoction combined with Sanrentang combined with body cavity heat perfusion in the treatment of hepatobiliary dampheat liver cancer with malignant ascites [J]. Med Innov China , 2022 , 19 ( 24 ): 15 - 20 .
程志琴 , 何文祥 . 加味三仁汤联合恩替卡韦治疗代偿期乙肝肝硬化的疗效及对肝纤维化程度、血清病毒学指标和免疫功能的影响 [J]. 四川中医 , 2018 , 36 ( 8 ): 90 - 92 .
CHENG Z Q , HE W X . Effect of modified Sanrentang combined with entecavir in the treatment of compensatory hepatitis B cirrhosis and its influence on the degree of liver fibrosis,serum virological indicators and immune function [J]. J Sichuan Tradit Chin Med , 2018 , 36 ( 8 ): 90 - 92 .
师小萌 , 王月美 , 边莉 , 等 . 三仁汤合芍药甘草汤加减辨证治疗湿热蕴阻证成人过敏性紫癜疗效及对血清EGF、PAF-AH水平的影响 [J]. 现代中西医结合杂志 , 2021 , 30 ( 9 ): 949 - 953,958 .
SHI X M , WANG Y M , BIAN L , et al . Efficacy of Sanrentang plus Shaoyao Gancao decoction on adult Henoch-Schonlein purpura of syndrome of damp-heat accumulation and its effect on serum levels of EGF and PAF-AH [J]. Mod J Integr Tradit Chin West Med , 2021 , 30 ( 9 ): 949 - 953,958 .
闫红琴 . 三仁汤加减辅治肾病综合征湿热内蕴型疗效观察 [J]. 实用中医药杂志 , 2023 , 39 ( 2 ): 291 - 293 .
YAN H Q . Observation on the therapeutic effect of modified San Ren Tang in the treatment of nephrotic syndrome with damp heat internal type [J]. J Pract Tradit Chin Med , 2023 , 39 ( 2 ): 291 - 293 .
代小艳 . 桃红三仁汤治疗难治性肾病综合征湿热夹瘀型的临床研究 [D]. 昆明 : 云南中医药大学 , 2021 .
DAI X Y . Clinical study of Taohong Sanrentang in the treatment of refractory nephrotic syndrome with dampness- heat and blood stasis [D]. Kunming : Yunnan University of Traditional Chinese Medicine , 2021 .
焦璐璐 , 王体敬 . 加味三仁汤治疗湿热内蕴型痛风性肾病临床观察 [J]. 山西中医 , 2024 , 40 ( 6 ): 19 - 22 .
JIAO L L , WANG T J . Efficacy observation of modified Sanrentang on gouty nephropathy with syndrome of heat-damp retention in the interior [J]. Shanxi J Tradit Chin Med , 2024 , 40 ( 6 ): 19 - 22 .
陶嘉茵 , 王耀献 , 艾司南 , 等 . 基于三焦膜系理论探讨IgA肾病的病机和治疗 [J]. 中医药导报 , 2024 , 30 ( 7 ): 176 - 179 .
TAO J Y , WANG Y X , AI S N , et al . Exploring the pathogenesis and treatment of IgA nephropathy based on the theory of triple focal membrane system [J]. Guid J Tradit Chin Med Pharm , 2024 , 30 ( 7 ): 176 - 179 .
刘怡秀 , 王耀献 , 柳红芳 , 等 . 基于三焦理论应用清热消癥法辨治IgA肾病 [J]. 环球中医药 , 2022 , 15 ( 5 ): 854 - 857 .
LIU Y X , WANG Y X , LIU H F , et al . Diagnosis and treatment of IgA nephropathy using the method of clearing heat and eliminating symptoms based on the theory of triple focus [J]. Global Tradit Chin Med , 2022 , 15 ( 5 ): 854 - 857 .
汪蕾 , 段昱方 , 赵文景 , 等 . 益气三仁汤治疗气虚湿热型IgA肾病临床观察 [J]. 世界中西医结合杂志 , 2015 , 10 ( 10 ): 1424 - 1426 .
WANG L , DUAN Y F , ZHAO W J , et al . Clinical observation on Yiqi Sanrentang in treating IgA nephropathy with Qi deficiency and damp-heat type [J]. World J Integr Tradit West Med , 2015 , 10 ( 10 ): 1424 - 1426 .
柴小琴 , 冯文哲 , 雷彪 , 等 . 三仁汤加减治疗急性期溃疡性结肠炎(湿热证)患者的临床研究 [J]. 中国中医急症 , 2022 , 31 ( 3 ): 381 - 383,398 .
CHAI X Q , FENG W Z , LEI B , et al . Clinical study on the modified Sanrentang in the treatment of patients with acute attack of damp-heat type ulcerative colitis [J]. J Emerg Tradit Chin Med , 2022 , 31 ( 3 ): 381 - 383,398 .
卢超 , 桂炜炜 , 刘艳 . 三仁汤加减配合协定处方灌肠治疗湿热型溃疡性结肠炎临床研究 [J]. 临床医药实践 , 2022 , 31 ( 5 ): 327 - 329 .
LU C , GUI W W , LIU Y . Clinical study on treatment of damp-heat ulcerative colitis with Sanrentang and agreement pre-scription enema [J]. Proceed Clin Med , 2022 , 31 ( 5 ): 327 - 329 .
许海健 . 三仁汤通过调节HMGB1/AGE/RAGE通路对溃疡性结肠炎肠道黏膜功能的影响及研究 [D]. 南京 : 南京中医药大学 , 2024 .
XU H J . Effect of Sanrentang on intestinal mucosal function in ulcerative colitis by regulating HMGB1/AGE/RAGE pathway [D]. Nanjing : Nanjing University of Traditional Chinese Medicine , 2024 .
赵仑 . 小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效及对MTL、SP、VIP的影响 [J]. 辽宁中医药大学学报 , 2022 , 24 ( 6 ): 123 - 126 .
ZHAO L . Effect of Xiaochaihu Sanrentang(小柴胡三仁汤)on constipation of dampness heat accumulation type after rectal cancer operation and the influence of MTL,SP and VIP [J]. J Liaoning Univ Tradit Chin Med , 2022 , 24 ( 6 ): 123 - 126 .
何鸳 , 姜华 , 常荷 , 等 . 三仁汤治疗女性出口梗阻便秘疗效的超声评估 [J]. 现代中医药 , 2020 , 40 ( 6 ): 62 - 65 .
HE Y , JIANG H , CHANG H , et al . An ultrasonic evaluation of sanrentang in the treatment of female OOC [J]. Mod Tradit Chin Med , 2020 , 40 ( 6 ): 62 - 65 .
高鹤 , 李会娟 , 郭家奎 , 等 . 针刺结合三仁汤治疗中风后湿热中阻型便秘临床疗效观察 [J]. 内蒙古中医药 , 2018 , 37 ( 12 ): 64 - 66 .
GAO H , LI H J , GUO J K , et al . The treating of damp-heat blocking middle jiao constipation after apoplexy by acupuncture combined with Sanrentang [J]. Neimonggu J Tradit Chin Med , 2018 , 37 ( 12 ): 64 - 66 .
郑文静 , 高慧峰 , 马君 , 等 . 三仁汤联合抗阻运动在2型肥胖糖尿病中的应用分析 [J]. 辽宁中医杂志 , 2023 , 50 ( 5 ): 164 - 167 .
ZHENG W J , GAO H F , MA J , et al . Application analysis of Sanrentang(三仁汤) combined with resistance exercise in type 2 obesity and diabetes [J]. Liaoning J Tradit Chin Med , 2023 , 50 ( 5 ): 164 - 167 .
林慧婷 , 王体敬 . 加味三仁汤治疗脾肾亏虚兼湿热壅滞型2型糖尿病肾病临床观察 [J]. 山西中医 , 2023 , 39 ( 7 ): 23 - 25 .
LIN H T , WANG T J . Efficacy observation of modified Sanrentang on type 2 diabetic nephropathy with syndrome of deficiency of spleen-kidney and stagnation of damp-heat [J]. Shanxi J Tradit Chin Med , 2023 , 39 ( 7 ): 23 - 25 .
黄雅兰 , 黄国东 , 蔡林坤 , 等 . 补阳还五汤合三仁汤加减治疗早期糖尿病肾病脾肾亏虚兼湿热瘀血证的临床观察 [J]. 中国实验方剂学杂志 , 2020 , 26 ( 5 ): 60 - 68 .
HUANG Y L , HUANG G D , CAI L K , et al . Clinical efficacy of modified Buyang Huanwu Tang combined with Sanrentang in treatment of spleen and kidney deficiency and damp-heat and blood stasis syndrome in early diabetic nephropathy [J]. Chin J Exp Tradit Med Form , 2020 , 26 ( 5 ): 60 - 68 .
邹冬吟 , 张喜民 , 范英 , 等 . 三仁汤联合常规疗法对糖尿病周围神经病变的临床疗效及血清胰岛素样生长因子-1、肿瘤坏死因子- α 水平的影响 [J]. 安徽医药 , 2022 , 26 ( 12 ): 2529 - 2533 .
ZOU D Y , ZHANG X M , FAN Y , et al . The clinical efficacy of Sanrentang combined with conventional therapy in the treatment of diabetic peripheral neuropathy and its influences on the serum insulin-like growth factor-1 and tumor necrosis factor- α levels [J]. Anhui Med Pharm J , 2022 , 26 ( 12 ): 2529 - 2533 .
徐应吉 , 郭奕妤 , 杨登科 . 三仁汤联合甘草酸苷片治疗脂溢性脱发(湿热型)临床观察 [J]. 皮肤病与性病 , 2021 , 43 ( 4 ): 530 - 532 .
XU Y J , GUO Y Y , YANG D K . Clinical observation on the treatment of seborrheic alopecia (damp heat type) with Sanrentang combined with glycyrrhizin tablets [J]. J Dermatol Venereol , 2021 , 43 ( 4 ): 530 - 532 .
张更新 . 三仁汤化裁联合红霉素软膏治疗脾胃湿热型痤疮的疗效观察 [J]. 新疆中医药 , 2021 , 39 ( 3 ): 15 - 18 .
ZHANG G X . Observation on the therapeutic effect of Sanrentang combined with erythromycin ointment in the treatment of spleen stomach damp heat acne [J]. Xinjiang J Tradit Chin Med , 2021 , 39 ( 3 ): 15 - 18 .
杨广宇 . 三仁汤加减治疗特发性血小板减少性紫癜患者的疗效及对血清生化指标的影响 [J]. 中国药物滥用防治杂志 , 2023 , 29 ( 3 ): 513 - 516 .
YANG G Y . Effect of modified Sanrentang on patients with idiopathic thrombocytopenic purpura and its effect on serum biochemical indexes [J]. Chin J Drug Abuse Prevent Treat , 2023 , 29 ( 3 ): 513 - 516 .
邹先明 , 吴莹 , 吴欢 . 三仁汤对脾胃湿热证型胃癌癌前病变模型大鼠的作用机理 [J]. 云南中医中药杂志 , 2020 , 41 ( 11 ): 63 - 66 .
ZOU X M , WU Y , WU H . Mechanism of Sanrentang on gastric precancerous lesions in model rats with spleen-stomach damp-heat syndrome [J]. Yunnan J Tradit Chin Med Mater Med , 2020 , 41 ( 11 ): 63 - 66 .
彭林佳 , 刁建新 , 薛文秀 , 等 . 三仁汤对脾胃湿热型大鼠NLRP3、Caspase-1蛋白的影响 [J]. 世界科学技术—中医药现代化 , 2020 , 22 ( 6 ): 1899 - 1904 .
PENG L J , DIAO J X , XUE W X , et al . Effect of Sanrentang on NLRP3 and Caspase-1 protein in rats with spleen-stomach damp-heat [J]. World Sci Technol Mod-Tradit Chin Med , 2020 , 22 ( 6 ): 1899 - 1904 .
隆卫阳 , 李墨辞 , 吴同玉 . 三仁汤对肝纤维化模型大鼠血清炎症因子及血小板衍生生长因子的影响 [J]. 中医药通报 , 2024 , 23 ( 1 ): 61 - 66 .
LONG W Y , LI M C , WU T Y . The effect of Sanrentang on serum inflammatory factors and platelet-derived growth factor in liver fibrosis model rats [J]. Tradit Chin Med J , 2024 , 23 ( 1 ): 61 - 66 .
李墨辞 . 基于TGF- β 1 /Smads信号通路探讨三仁汤防治肝纤维化的作用机制 [D]. 福州 : 福建中医药大学 , 2022 .
LI M C . Study on the mechanism of Sanrentang in prevention Hepatic fibrosis based on TGF- β 1 /Smads signaling pathaway [D]. Fuzhou : Fujian University of Traditional Chinese Medicine , 2022 .
王广伟 , 张禹 , 张佳宁 , 等 . 基于PI3K/Akt/NF-κB信号通路探讨加味三仁汤对脂多糖诱导的大鼠肾小球系膜细胞增殖的影响 [J]. 中国实验方剂学杂志 , 2022 , 28 ( 5 ): 32 - 37 .
WANG G W , ZHANG Y , ZHANG J N , et al . Effect of modified Sanrentang on lipopolysaccharide-induced proliferation of rat glomerular mesangial cells based on PI3K/Akt/NF- κ B pathway [J]. Chin J Exp Tradit Med Form , 2022 , 28 ( 5 ): 32 - 37 .
王广伟 , 张禹 , 张佳宁 , 等 . 加味三仁汤对免疫球蛋白A肾病大鼠PI3K/AKT/NF- κ B信号通路的影响 [J]. 中药药理与临床 , 2021 , 37 ( 5 ): 11 - 17 .
WANG G W , ZHANG Y , ZHANG J N , et al . Effect of Jiawei Sanrentang on PI3K/Akt/NF- κ B signaling Pathway in immunoglobulin A nephropathy rats [J]. Pharmacol Clin Chin Mater Med , 2021 , 37 ( 5 ): 11 - 17 .
程硕 . 基于网络药理学及实验探究三仁汤治疗多发性硬化症的机制 [D]. 北京 : 北京中医药大学 , 2023 .
CHENG S . Exploring the mechanism of Sanrentang in treating multiple sclerosis based on network pharmacology and experimental research [D]. Beijing : Beijing University of Chinese Medicine , 2023 .
江望 , 田生望 , 贺单 , 等 . 基于Tim-3/aletin-9信号通路探讨三仁汤对Hp相关性脾胃湿热证胃炎症状改善及巨噬细胞极化的影响 [J]. 世界科学技术—中医药现代化 , 2025 , 27 ( 2 ): 484 - 491 .
JIANG W , TIAN S W , HE D , et al . Exploring the effects of San Ren decoction on the improvement of symptoms and macrophage polarization of H.pylori-associated gastritis and spleen and stomach damp heat syndrome based on Tim-3/aletin-9 signaling pathway [J]. World Sci Technol Mod Tradit Chin Med , 2025 , 27 ( 2 ): 484 - 491 .
胡锋 , 胡小军 , 李建伟 , 等 . 三仁汤调控骨关节炎大鼠关节疼痛和软骨损伤机制研究 [J]. 时珍国医国药 , 2022 , 33 ( 6 ): 1348 - 1350 .
HU F , HU X J , LI J W , et al . Study on the mechanism of Sanrentang regulating joint pain and cartilage injury in osteoarthritis rats [J]. Lishizhen Med Mater Med Res , 2022 , 33 ( 6 ): 1348 - 1350 .
邓丹萍 , 谢天喜 , 刘向儒 , 等 . 基于UHPLC-Q-Orbitrap HRMS整合网络药理学探讨三仁汤治疗新型冠状病毒肺炎的潜在作用机制 [J]. 陕西中医药大学学报 , 2023 , 46 ( 5 ): 39 - 47 .
DENG D P , XIE T X , LIU X R , et al . Exploring the potential mechanism of Sanrentang in treating novel coronavirus pneumonia based on UHPLC-Q-Orbitrap HRMS integrated network pharmacology [J]. J Shaanxi Coll Tradit Chin Med , 2023 , 46 ( 5 ): 39 - 47 .
李嘉丽 , 杨良俊 , 周恒立 , 等 . 网络药理学及分子对接法探讨三仁汤主要成分对新型冠状病毒肺炎(COVID-19)的机制研究 [J]. 中草药 , 2020 , 51 ( 9 ): 2345 - 2353 .
LI J L , YANG L J , ZHOU H L , et al . Mechanism of sovereign medicines in Sanrentang on COVID-19 based on network pharmacology and molecular docking [J]. Chin Tradit Herb Drug , 2020 , 51 ( 9 ): 2345 - 2353 .
戴淑颖 , 张郜晨茜 , 陈婷 , 等 . 基于网络药理学和分子对接研究三仁汤治疗肺癌的分子机制 [J]. 新中医 , 2020 , 52 ( 22 ): 31 - 39 .
DAI S Y , ZHANG G C X , CHEN T , et al . A study on molecular mechanism of Sanren Tang in treating lung cancer based on network pharmacology and molecular docking [J]. J New Chin Med , 2020 , 52 ( 22 ): 31 - 39 .
YI Y , HAO T , YI F , et al . Hepatic transcriptome delineates the therapeutic effects of Sanren Tang on high-fat diet-induced non-alcoholic fatty liver disease .[J] J Tradit Chin Med , 2023 , 43 ( 6 ): 1092 - 1102 .
庄凌云 , 张桂菊 , 崔有利 , 等 . 三仁汤对湿热证型病毒性肺炎模型小鼠免疫功能的干预作用 [J]. 山东中医药大学学报 , 2019 , 43 ( 5 ): 508 - 512 .
ZHUANG L Y , ZHANG G J , CUI Y L , et al . Intervention effects of Sanrentang on immune function of model mice with virus pneumonia of dampness-heat syndrome [J]. J Shandong Univ Tradit Chin Med , 2019 , 43 ( 5 ): 508 - 512 .
季旭明 , 庄凌云 , 崔有利 , 等 . 三仁汤对湿热证型病毒性肺炎小鼠模型的多靶点干预作用 [J]. 中华中医药学刊 , 2019 , 37 ( 6 ):1287-1289, 1537 - 1538 .
JI X M , ZHUANG L Y , CUI Y L , et al . Effect of Sanrentang target on damp heat syndrome of virus pneumonia in mice model [J]. Chin Arch Tradit Chin Med , 2019 , 37 ( 6 ):1287-1289, 1537 - 1538 .
崔璀 , 张振巍 . 加味三仁汤对脾胃湿热证大鼠氧化应激、能量代谢及免疫平衡的影响 [J]. 中成药 , 2022 , 44 ( 11 ): 3677 - 3680 .
CUI C , ZHANG Z W . Effects of modified Sanrentang on oxidative stress,energy metabolism,and immune balance in rats with spleen stomach damp heat syndrome [J]. Chin Tradit Patent Med , 2022 , 44 ( 11 ): 3677 - 3680 .
黄良武 . 以三仁汤为代表的通调三焦法调节ICC治疗功能性便秘的机制研究 [D]. 咸阳 : 陕西中医药大学 , 2023 .
HUANG L W . The regulation of Tongtiao Sanjiao method represented by Sanrentang Study on the Mechanism of ICC Treatment of Functional Constipation [D]. Xianyang : Shaanxi University of Traditional Chinese Medicine , 2023 .
赖鹏华 , 单晓梅 , 卢大为 , 等 . 三仁汤对湿热应激小鼠肺组织黏蛋白5AC、水通道蛋白1、水通道蛋白5表达的影响 [J]. 中医杂志 , 2017 , 58 ( 5 ): 410 - 413 .
LAI P H , SHAN X M , LU D W , et al . Effect of Sanren Tang(三仁汤)on Mucin 5AC,Aquaporin 1 and Aquaporin 5 in lung tissue of damp-heat stressed mice [J]. J Tradit Chin Med , 2017 , 58 ( 5 ): 410 - 413 .
江望 , 田生望 , 贺单 , 等 . 三仁汤对幽门螺杆菌相关性胃炎脾胃湿热证大鼠消化吸收功能及Akt/NF- κ B通路的影响 [J]. 中国现代应用药学 , 2024 , 41 ( 12 ): 1663 - 1670 .
JIANG W , TIAN S W , HE D , et al . Effect of Sanrentang on digestion and absorption function and Akt/NF- κ B pathway in rats with helicobacter pylori-associated gastritis and spleen and stomach damp heat syndrome [J]. Chin J Mod Appl Pharm , 2024 , 41 ( 12 ): 1663 - 1670 .
曹文斌 , 周晗 , 刘洋 , 等 . 三仁汤对慢传输型便秘大鼠治疗作用及对MAPK/NF- κ B信号通路影响 [J]. 辽宁中医药大学学报 , 2023 , 25 ( 9 ): 24 - 28,221 .
CAO W B , ZHOU H , LIU Y , et al . Therapeutic effect of Sanrentang(三仁汤)on slow transit constipation in rats and the effect of MAPK/NF- κ B signal pathway [J]. J Liaoning Univ Tradit Chin Med , 2023 , 25 ( 9 ): 24 - 28,221 .
尹艺晓 , 唐浩 , 刘伟 , 等 . 三仁汤各提取部位对高脂饮食诱导的小鼠非酒精性脂肪肝的作用 [J]. 中国医院药学杂志 , 2022 , 42 ( 22 ): 2320 - 2324 .
YIN Y X , TANG H , LIU W , et al . Effects of effective fractions of Sanren Tang on nonalcoholic fatty liver induced by high-fat diet in mice [J]. Chin J Hosp Pharm , 2022 , 42 ( 22 ): 2320 - 2324 .
洪冰 , 李云鹏 , 武凯歌 , 等 . 三仁汤对脾胃湿热证大鼠神经内分泌免疫功能影响的研究 [J]. 现代消化及介入诊疗 , 2014 , 19 ( 3 ): 147 - 149,152 .
HONG B , LI Y P , WU K G , et al . Effects of Sanrentang on neuroendocrine-immune functions of the spleen and stomach damp-heat syndrome in rats [J]. Mod Digest Intervent , 2014 , 19 ( 3 ): 147 - 149,152 .
李云鹏 , 文小敏 , 武凯歌 , 等 . 三仁汤对脾胃湿热证大鼠行为学及下丘脑-垂体-肾上腺轴的影响 [J]. 南方医科大学学报 , 2010 , 30 ( 1 ): 126 - 128 .
LI Y P , WEN X M , WU K G , et al . The effect of Sanrentang on the behavior and hypothalamic pituitary adrenal axis of rats with spleen stomach damp heat syndrome [J]. J South Med Univ , 2010 , 30 ( 1 ): 126 - 128 .
张娟娟 , 张曦 , 杨逸璇 , 等 . 加味三仁汤联合石榴皮多酚乳膏对湿热痰瘀型金黄地鼠痤疮模型脂质组学的影响 [J]. 湖南中医药大学学报 , 2022 , 42 ( 10 ): 1641 - 1649 .
ZHANG J J , ZHANG X , YANG Y X , et al . Effects of combining modified Sanrentang and pomegranate peel polyphenol cream on lipidomics of golden hamsters acne model of damp-heat and phlegm-stasis type [J]. J Tradit Chin Med Univ Hunan , 2022 , 42 ( 10 ): 1641 - 1649 .
张娟娟 . 基于分消走泄法探讨中药内外合治改善痤疮脾胃湿热证皮脂代谢紊乱的作用机理研究 [D]. 长沙 : 湖南中医药大学 , 2023 .
ZHANG J J . Study on the mechanism of traditional Chinese medicine internal and external combination treatment in improving sebum metabolism disorder in acne spleen stomach damp heat syndrome based on the method of dividing and eliminating diarrhea [D]. Changsha : Hunan University of Traditional Chinese Medicine , 2023 .
杨梦晗 , 吴长汶 , 熊文慧 , 等 . 基于三焦理论探讨代谢综合征的病因病机及治疗 [J]. 中医药通报 , 2024 , 23 ( 5 ): 10 - 13 .
YANG M H , WU C W , XIONG W H , et al . Exploring the etiology,pathogenesis,and treatment of metabolic syndrome based on the theory of triple focus [J]. Tradit Chin Med J , 2024 , 23 ( 5 ): 10 - 13 .
王晓翠 , 牛阳 , 陈洁 . 三仁汤的现代文献计量学和研究热点分析 [J]. 中医学报 , 2021 , 36 ( 5 ): 1120 - 1125 .
WANG X C , NIU Y , CHEN J . Analysis of modern bibliometrics and research hotspots of sanrentang [J]. Acta Chin Med , 2021 , 36 ( 5 ): 1120 - 1125 .
吴智鹏 , 张钰琴 , 曾国圆 , 等 . 基于“三焦分消”理念分析三仁汤“异病同治”治疗溃疡性疾病的临证思路 [J]. 吉林中医药 , 2024 , 44 ( 3 ): 253 - 256 .
WU Z P , ZHANG Y Q , ZENG G Y , et al . Clinical thinking of Sanrentang treating different diseases with the same method in the treatment of ulcerative diseases based on the concept of eliminating pathogens in Sanjiao [J]. Jilin J Tradit Chin Med , 2024 , 44 ( 3 ): 253 - 256 .
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