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Auswirkungen des PINK1 / Parkin-Wegs auf das Modell von Mäusen mit Ovarialalterung

  • role： First author第一作者
  • Affiliation：

    School of Integrated Chinese and Western Medicine， School of Chinese Medicine， The Second Affiliated Hospital， School of Medicine， and Hunan Provincial Key Laboratory of Translational Medicine in Traditional Chinese Medicine Formula-Syndrome Research， Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：601169594@qq.com
  • Introduction：王凯玲，在读硕士，从事女性内分泌疾病的中医药防治研究，E-mail：601169594@qq.com
WANG Kailing,  
  • Affiliation：

    School of Integrated Chinese and Western Medicine， School of Chinese Medicine， The Second Affiliated Hospital， School of Medicine， and Hunan Provincial Key Laboratory of Translational Medicine in Traditional Chinese Medicine Formula-Syndrome Research， Hunan University of Chinese Medicine， Changsha 410208， China

JING Yichen,  
  • Affiliation：

    School of Integrated Chinese and Western Medicine， School of Chinese Medicine， The Second Affiliated Hospital， School of Medicine， and Hunan Provincial Key Laboratory of Translational Medicine in Traditional Chinese Medicine Formula-Syndrome Research， Hunan University of Chinese Medicine， Changsha 410208， China

WANG Guiyun,  
  • Affiliation：

    School of Integrated Chinese and Western Medicine， School of Chinese Medicine， The Second Affiliated Hospital， School of Medicine， and Hunan Provincial Key Laboratory of Translational Medicine in Traditional Chinese Medicine Formula-Syndrome Research， Hunan University of Chinese Medicine， Changsha 410208， China

LI Yueheng,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Integrated Chinese and Western Medicine， School of Chinese Medicine， The Second Affiliated Hospital， School of Medicine， and Hunan Provincial Key Laboratory of Translational Medicine in Traditional Chinese Medicine Formula-Syndrome Research， Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：1074983953@qq.com
  • Introduction：刘慧萍，博士生导师，从事女性内分泌疾病的中医药防治研究，E-mail：1074983953@qq.com
LIU Huiping*

Resümee

Das Ziel dieser Studie ist es, die Auswirkungen des Ernährungswegs zu beobachten, der die mitochondriale Autophagie aktiviert, die Eierstockfunktionen bei Mäusen mit Ovarialalterung reguliert und von verschiedenen behandelt wurde: niedrige, mittlere und hohe Dosis rosa Futter (9,72, 19,44 und 38,88 g / kg), werden signifikant erhöht (p <0,01) ; Der AMH-Gehalt im Blut und der E2-Gehalt im Serum steigen signifikant an (p <0,01) ; mit Ausnahme der niedrig dosierten Ernährungsgruppe steigen die E2- und LH-Spiegel im Serum signifikant an und nehmen entsprechend ab (p <0,05, p <0,01) ; alle Behandlungen verbessern die Anzahl der Follikel unterschiedlicher Ebenen und helfen dabei, die Anzahl der geschlossenen Follikel zu reduzieren ; Unter dem Mikroskop werden Veränderungen in den Mitochondrien, Änderungen in der Struktur, sichtbare autophagische Lysosomen beobachtet ; alle Behandlungen erhöhen signifikant die Expression der Proteine PINK1, Parkin, LC3B, p62 im Ovarialgewebe (p <0,05, p <0,01).

Schlüsselwort

Rosa Ernährungsweg ; Ovarialalterung ; Mitochondriale Autophagie ; Durch den Ernährungsweg aktiviertes PTEN

References

  1. 1.
    DAI W，YANG H，XU B，et al. 3D hUC-MSC spheroids exhibit superior resistance to autophagy and apoptosis of granulosa cells in POF rat model［J］.Reproduction，2024，168 （2）：e230496.
  2. 2.
    ZHOU Q，LU Y C. New progress in the treatment of premature ovarian failure［J］.Chin J Med Guide，2023，25（1）：35-38.
  3. 3.
    LIU D D， QIN H W. Mechanism of action and progress of mitophagy，ferroptosis，cuproptosis，and disulfidptosis inAlzheimer's disease［J］.Chin J Tissue Engin Res，2025，29（19）：4132-4144.
  4. 4.
    LU Y，LI Z，ZHANG S，et al.Cellular mitophagy：Mechanism，roles in diseases and small molecule pharmacological regulation［J］.Theranostics，2023，13 （2）：736-766.
  5. 5.
    WANG S，LONG H，HOU L，et al. The mitophagy pathway and its implications in human diseases［J］.Signal Transduct Target Ther，2023，8 （1）：304.
  6. 6.
    YAN J ， LI F ，WU K M， et al. The molecular mechanisms by which Xin Jia Cistanche Tusi decoction promotes follicular development through mitophagy［J］.Shandong Sci，2024，37（5）：25-34.
  7. 7.
    WU Q， ZHANG Y Y， LIU H P， et al. Professor You Zhaoling's treatment experience with premature ovarian insufficiency［J］.Shaanxi J Tradit Chin Med，2021，42（7）：941-943.
  8. 8.
    ZHANG Y Y， LIU H P， YOU Z L， et al. YOU Zhao-ling's experience in treating premature ovarian failure fromdeficiency and stasis［J］.China J Tradit Chin Med Pharm，2020，35（7）：3440-3443.
  9. 9.
    DONG R X， ZHU X D， FAN B Z， et al. Establishment of a chemotherapy-induced ovarian failure model in rats with different doses of cisplatin via intraperitoneal injection［J］.Labor Animal Comp Med，2020，40（2）：104-109.
  10. 10.
    WANG H，WU J L.Pharmacological experiments［M］. Wuhan：Hubei Science and Technology Publishing House，2007：8.
  11. 11.
    LI H， LIU H P， XIAO J L J， et al. Effect of Bushen Huoxue prescription on exosome-related membrane proteins in ovarian tissue of rats with premature ovarian failure［J］.J Hunan Univ Chin Med，2022，42（6）：885-892.
  12. 12.
    WANG J，WU S h，SHANG H X.Observation of the estrous cycle in adult female SD rats［J］.Contemp Med，2013，19（28）：25-26.
  13. 13.
    XIA X Y， LIANG Y， DONG L， et al. Discussion on acupuncture treatment of premature ovarian insufficiency from "kidney-tiangui-chongrenuterus" reproductive axis and "Xuanfu theory［J］.Acad J Shanghai Univ Tradit Chin Med，2024，38（4）：87-91.
  14. 14.
    LIU H P， YOU Z L， LEI L， et al. Effect of Bushenhuoxue prescription on Bcl-2/Bax prote in of apoptosis contress genes in follicle of immune premature ovarian failure mice［J］.Chin Arch Tradit Chin Med，2010，28（5）：1036-1038.
  15. 15.
    ZHANG Y Y， ZHANG S M， LIU P A， et al. Contents determination of loganin， morroniside and paeoniflorin in Bushen Huoxue prescription and its effect on mice with immune premature ovarian failure［J］.J Hunan Univ Chin Med，2020，40（5）：540-545.
  16. 16.
    China Association of Chinese Medicine.Integration of traditional Chinese and western medicine in the diagnosis and treatment of premature ovarian failure［J］.Chin J Integr Tradit West Med，2024，44（10）：1167-1179.
  17. 17.
    SPEARS N，LOPES F，STEFANSDOTTIR A，et al.Ovarian damage from chemotherapy and current approaches to its protection［J］.Hum Reprod Update，2019，25（6）：673-693.
  18. 18.
    ALESI L R， NGUYEN Q N， STRINGER J M， et al. The future of fertility preservation for women treated with chemotherapy［J］.Reprod Fertil，2023，4（2）：e220123.
  19. 19.
    YAN F， LIU Y F，ZHAO Q， et al. Mechanism of mitochondrial quality control in ovarian aging and intervention of traditional Chinese medicine：A review［J］.Chin J Exp Tradit Med Form，2024，30（18）：291-298.
  20. 20.
    NG M，WAI T，SIMONSEN A. Quality control of the mitochondrion［J］.Dev Cell，2021，56 （7）：881-905.
  21. 21.
    ALBERICO H C，WOODS D C. Role of granulosa cells in the aging ovarian landscape：A focus on mitochondrial and metabolic function［J］.Front Physiol，2021，12：800739.
  22. 22.
    LI R M，ZHAO J，LIU Y. PINK1/Parkin-mediated mitophagy［J］.Chin J Biochem Mol Biol，2019，35（10）：1072-1079.
  23. 23.
    WAMG X X，LING J H，WANG Y J，et al.Regulation of mitochondrial autophagy by Pink1/Parkin signaling pathway［J］.Genom Appl Biol，2022，41（4）：919-926.
  24. 24.
    BERTOLIN G，FERRANDO-MIGUEL R，JACOUPY M，et al. The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance［J］.Autophagy，2013，9 （11）：1801-1817.
  25. 25.
    LIANG D Y， DAI H C. The role of PINK1/Parkin pathway mitophagy in oxidative damage［J］.Chin J Cell Biol，2018， 40（1）：116-123.
  26. 26.
    CHEN L B，MA K L，CHEN Q，et al.Mechanism of mitophagy in cell homeostasis［J］.Sci Sin（Vitae），2019，49（9）：1045-1053.
  27. 27.
    CHEN Y S，SONG F Y. Research progress on selective autophagy receptor p62/sequestosome 1［J］.Chin J Pharmacol Toxicol，2016，30（3）：258-265.
  28. 28.
    LÜ X X， HU Z W. New methods to detect autophagic flux［J］.Acta Pharmaceutica Sinica，2016，51（1）：45-51.
  29. 29.
    MA T，SUN G P，LI J B.Research methods of cellular autophagy［J］.Prog Biochem Biophy，2012，39（3）：204-209.

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