EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia-reperfusion in Isolated Rat Hearts

Hu Yingming; Chen Qi; Zhang Wenran

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EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia-reperfusion in Isolated Rat Hearts

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- EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia-reperfusion in Isolated Rat Hearts
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 1, Issue 1, Pages: 18-21(1995)
- 作者机构：
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  CLC： R259.871R285.5
- Published：1995
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Hu Yingming, Chen Qi, Zhang Wenran. EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia-reperfusion in Isolated Rat Hearts[J]. Chinese Journal of Experimental Traditional Medical Formulae, 1995, 1(1): 18-21.
DOI：

Hu Yingming, Chen Qi, Zhang Wenran. EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia-reperfusion in Isolated Rat Hearts[J]. Chinese Journal of Experimental Traditional Medical Formulae, 1995, 1(1): 18-21. DOI：

摘要

本文在Langendorff装置上观察了炙甘草汤对大鼠离体心脏冠状动脉前降支结扎再灌注损伤的影响。结果表明

炙甘草汤(8g/L)能显著降低结扎期室性心动过速(VT)

再灌注期室颤(VF)和心律失常总发生率

抑制心肌细胞中磷酸肌酸激酶(CPK)和乳酸脱氢酶(LDH)的释放

炙甘草汤2

8g/L均能显著降低再灌注心肌组织中脂质过氧化物丙二醛(MDA)含量、增强过氧化物歧化酶(SOD)活性。炙甘草汤的以上作用与钙拮抗剂维拉帕米(Verapamil

0.5μmol/L)作用相似。

Abstract

Using Langendorff’s device for coronary artery ligation and reperfusion

effects of Zhigancao decoctoin on myocardial damage induced by ligating and reperfusing descending anterior branch of coronary artery were studied in isolated rat hearts.Zhigancao decoction at a dose of 8g/L was found to produce a marked reduction in the incidence of VT during ligation(ishenua)

VF after reperfusion

and arrhythmia in rats.It also remarkably inhibited CPK or LDH release from mvocardial cells. In addition

Zhigancao decoction at doses of 2

and 8g/L appeared to increase the activity of SOD and decrease the level of MDA in myocardial tissue. All these effects were similar to those of verapamil(0.5μmol/L).

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