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Multidrug Resistance in Breast Cancer and Coping Strategies of Chinese Medicine： A Review
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 28, Issue 13, Pages: 250-259(2022)
- 作者机构：
中国中医科学院 中药研究所，北京 100700
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20220803
CLC： R2-0;R22;R285.5;R284;R33Published：05 July 2022，
Published Online：11 February 2022，
Received：05 December 2021，
- 稿件说明：
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崔羲和,曾蕊,杨庆等.乳腺癌多药耐药的研究现状及中医药应对策略[J].中国实验方剂学杂志,2022,28(13):250-259.
CUI Xihe,ZENG Rui,YANG Qing,et al.Multidrug Resistance in Breast Cancer and Coping Strategies of Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(13):250-259.
崔羲和,曾蕊,杨庆等.乳腺癌多药耐药的研究现状及中医药应对策略[J].中国实验方剂学杂志,2022,28(13):250-259. DOI： 10.13422/j.cnki.syfjx.20220803.
CUI Xihe,ZENG Rui,YANG Qing,et al.Multidrug Resistance in Breast Cancer and Coping Strategies of Chinese Medicine： A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(13):250-259. DOI： 10.13422/j.cnki.syfjx.20220803.
摘要
乳腺癌作为一种女性群体高发的恶性肿瘤，对人民健康造成了极大的威胁。目前，化疗是除手术及放疗外治疗乳腺癌的主要方法，但化疗过程常伴随着乳腺癌多药耐药（MDR）的产生，从而导致药物疗效降低、停药后癌症复发、医疗资源消耗量增大以及及医疗系统负担增加等一系列严重后果。以往研究证明，乳腺癌MDR机制相当复杂，涉及药物外排、DNA损伤修复、肿瘤微环境、自噬、表观遗传学调控、肿瘤干细胞及脂质代谢等一系列过程，且各耐药机制之间存在着广泛的联系。深入揭示MDR的产生机制，开发相应药物针对性地逆转MDR，提高乳腺癌化疗效果，是目前乳腺癌治疗的需要。中医药具有高效低毒，多靶点、整体调控的优势，大量研究发现，多种中药单体、单药及复方能够通过调控药物外排蛋白表达、促进凋亡、调节自噬等途径逆转乳腺癌MDR，表现出对抗乳腺癌MDR的潜力。据此，该文将对近年来关于乳腺癌MDR的产生机制及中医药应对乳腺癌MDR的研究进展进行系统的概括，为相关研究的进一步深入提供参考。
Abstract
Breast cancer， as a kind of malignant tumor with high incidence rate in female population， poses a great threat to people's health. At present， chemotherapy is the main treatment for breast cancer besides surgery and radiotherapy. However， chemotherapy is often accompanied by multidrug resistance （MDR）， which results in a series of severe consequences such as low efficacy， relapse of cancer after drug withdrawal， increased consumption of medical resources， and increased burden of medical system. Previous studies showed that the mechanism of MDR in breast cancer was quite complex， involving drug efflux， deoxyribonucleic acid （DNA） damage repair， tumor microenvironment， autophagy， epigenetic regulation， tumor stem cells， lipid metabolism， and so on. In addition， there were extensive connections among the mechanisms of MDR. Therefore， it is necessary to reveal the mechanism of MDR and develop corresponding drugs to reverse MDR， thus improving the effect of chemotherapy on treating breast cancer. Chinese medicine has the advantages of high efficiency， low toxicity， multi targets， and overall regulation. Various studies found that Chinese medicine monomer， single drug， and compound were able to reverse MDR in breast cancer by regulating the expression of drug efflux protein， promoting apoptosis， and regulating autophagy， showing the potential of anti-MDR in breast cancer. This paper summarized the research progress of the mechanism of MDR in breast cancer and the strategies of Chinese medicine in coping with MDR in breas cancer in recent years， and provided references for further research.
关键词
乳腺癌多药耐药（MDR）研究现状中医药应对策略
Keywords
breast cancermultidrug resistance （MDR）research statusChinese medicinecoping strategies
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