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Analysis of Brain Absorption Components and Their Distribution of Tianyuan Zhitong Prescription Based on UPLC-Q-TOF-MS and DESI-MSI
Updated:2024-06-18
    • Analysis of Brain Absorption Components and Their Distribution of Tianyuan Zhitong Prescription Based on UPLC-Q-TOF-MS and DESI-MSI

    • “2024年4月29日,中国中医科学院中药研究所的程怡、王锦玉、刘德文团队在《中国实验方剂学杂志》上发表了关于中药方剂“天元芷通方”入脑成分及脑内分布的研究。该研究利用超高效液相色谱-四极杆-飞行时间质谱法、解吸电喷雾电离-敞开式离子化质谱成像法以及高光谱成像技术,深入探讨了该方剂治疗头痛的药物成分及其在脑组织中的分布特征。研究团队通过精心设计的实验,成功鉴定出27个入脑成分,并揭示了这些成分在大脑不同区域的分布情况。同时,高光谱成像技术进一步验证了这些成分在脑组织中的物理性质或含量的差异,为复方质量标准研究指标成分的选择和药效作用机制研究提供了有力参考。该研究的成功,不仅为天元芷通方的临床应用提供了科学依据,也为中药方剂入脑成分的研究开辟了新的方向,对于推动中药现代化和国际化具有重要意义。”
    • CHENG Yi , LAN Qun , WU Bingyu , WANG Jinyu , LIU Dewen , TONG Yan
    • Chinese Journal of Experimental Traditional Medical Formulae Vol. 30, Issue 12, Pages: 166-172(2024)
    • DOI: 10.13422/j.cnki.syfjx.20240661     

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