“Er Chen Tang has therapeutic effects on obese depression model mice, and its mechanism of action is related to the regulation of the PPAR signaling pathway and the expression of related genes FABP1, ACOX1, PPAR α, CYP7A1, and PCK1. The research progress of Er Chen Tang in the field of traditional Chinese medicine treatment of metabolic diseases is introduced. The research team has established an evaluation system for obese depression models, verified the hypothesis of PPAR signaling pathway regulation, and provided a new solution for the prevention and treatment of obese depression by combining traditional Chinese and Western medicine.”